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The Value of Hybrid Angio-CT in Preoperative Detection and Localization of Insulinomas: A Single-Center Retrospective Study

  • Clinical Investigation
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Abstract

Objective

To investigate the performance of hybrid angio-CT in preoperative detection and localization for insulinomas.

Methods

Fifty-four postoperative pathology-confirmed patients from April 2015 to March 2017 were retrospectively reviewed; all patients underwent angio-CT with administration of contrast media in SMA, GDA and SA due to negative, inconclusive or controversial findings by several preoperative diagnostic methods including TAUS, CEUS, EUS, ECT, EMRI and DSA. Surgery was used as gold standard for localization of insulinomas; detection sensitivity and localization accuracy of angio-CT were assessed and compared with other preoperative image options.

Results

Fifty-six benign insulinomas (mean diameter, 15.8 mm) in 54 patients (18 men and 36 women) were found according to surgical results; the overall detection sensitivity of TAUS, CEUS, EUS, ECT, EMRI and DSA was 21.4, 78.4, 79.2, 70.0, 79.2 and 72.2%, respectively. The overall localization accuracy was 14.3, 58.8, 68.8, 60.0, 75.0 and 44.4%, respectively. A total of 53 tumors were detected by angio-CT, 51 tumors were accurately located, and the overall detection sensitivity and localization accuracy of angio-CT was 94.4 and 90.7%, which was significantly higher than that of all other preoperative diagnostic methods (p < 0.05). No any serious complications occurred during angio-CT.

Conclusion

Our study indicates the great potential value of angio-CT in the preoperative detection and localization of insulinomas; angio-CT can be used as a preferred invasive diagnostic method.

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Acknowledgements

The authors thank Jianfeng Xue, Jinshuan Xing and Shibin Wei, from the Department of Interventional Radiology, Chinese PLA General Hospital, for their technical support about MIYABI Angio-CT.

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Authors and Affiliations

  1. Department of Interventional Radiology, Chinese PLA General Hospital, 28 Fuxing Road, Beijing, 100853, People’s Republic of China

    Jinxin Fu, Fengyong Liu, Kai Yuan, Jieyu Yan, Yan Wang, Bing Yuan & Maoqiang Wang

  2. School of Medicine, Nankai University, Tianjin, 300071, People’s Republic of China

    Jinlong Zhang

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  1. Jinxin Fu
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  2. Fengyong Liu
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  3. Kai Yuan
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  4. Jieyu Yan
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  5. Yan Wang
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  6. Jinlong Zhang
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  7. Bing Yuan
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  8. Maoqiang Wang
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Correspondence to Maoqiang Wang.

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All authors declare that they have no conflict of interest.

Ethical Approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. For this type of study, formal consent is not required.

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Informed consent was obtained from all individual participants included in the study.

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Fu, J., Liu, F., Yuan, K. et al. The Value of Hybrid Angio-CT in Preoperative Detection and Localization of Insulinomas: A Single-Center Retrospective Study. Cardiovasc Intervent Radiol 41, 633–638 (2018). https://doi.org/10.1007/s00270-017-1847-2

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  • DOI: https://doi.org/10.1007/s00270-017-1847-2

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