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Study on the Influencing Factors of Short-Term Recovery of Neurological Symptoms after Carotid Body Tumor Resection

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Abstract

Objective

To compare the differences in the short-term recovery from neurological symptoms (SRN) (≤ 6 months) and clinical characteristics of patients with different Shamblin classifications carotid body tumor (CBT) resection and to analyze the risk factors affecting SRN after surgery.

Methods

Patients who underwent CBT resection between June 2018 and September 2022 were recruited. Perioperative factors and indicators of the nature of the tumor were recorded. The risk factors affecting SRN after CBT resection were analyzed using logistic regression analysis.

Results

Eighty-five patients (43.86 ± 12.7 years, 46 females) were included, 40 (47.06%) of whom exhibited SRN. Univariate logistic regression showed that preoperative symptoms, surgical side, bilateral posterior communicating artery (PcoA) opening, some indicators of tumor size, operative/anesthesia time, and Shamblin III classification were correlated with postoperative neurological prognosis (all p < 0.05). After adjusting for confounders, preoperative symptoms (OR, 5.072; 95% CI 1.027–25.052; p = 0.046), surgical side (OR, 0.025; 95% CI 0.003–0234; p = 0.001), bilateral PcoA opening (OR, 22.671; 95% CI 2.549–201.666; p = 0.005), distance from the tip of the C2 dens to the superior aspect (dens-CBT) (OR, 0.918; 95% CI 0.858–0.982; p = 0.013) and Shamblin III classification (OR, 28.488; 95% CI 1.986–408.580; p = 0.014) were correlated with postoperative neurological symptom recovery.

Conclusion

Preoperative symptoms, surgical side (right), bilateral PcoA opening, a short dens-CBT and Shamblin III classification are risk factors affecting SRN after CBT resection. Early resection is recommended for small-volume CBTs without neurovascular compression or invasion to obtain SRN.

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Acknowledgements

Not applicable.

Funding

This research was supported by the National Natural Science Foundation of China (No. 82071308).

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Authors and Affiliations

  1. Department of Neurosurgery, Peking University Third Hospital, 49 North Garden Road, Haidian District, Beijing, 100191, China

    Wanzhong Yuan, Chaofan Hou, Zhongzheng Wang, Jun Yang & Tao Wang

  2. Department of Radiology, Peking University Third Hospital, Beijing, China

    Ran Huo

Authors
  1. Wanzhong Yuan
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  2. Ran Huo
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  3. Chaofan Hou
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  4. Zhongzheng Wang
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  5. Jun Yang
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  6. Tao Wang
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Contributions

Conception and design contributed by TW, WZY. Analysis and interpretation contributed by WZY, TW. Data collection contributed by WZY, RH, CFH, ZZW. Critical revision of the article contributed by TW, JY. Statistical analysis contributed by WZY, CFH, ZZW.

Corresponding author

Correspondence to Tao Wang.

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The authors declare that they have no conflict of interest.

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Informed consent was obtained from all individual participants included in the study.

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The study protocol followed the tenets of the Declaration of Helsinki and was approved by the Science Research Ethics Committee.

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Yuan, W., Huo, R., Hou, C. et al. Study on the Influencing Factors of Short-Term Recovery of Neurological Symptoms after Carotid Body Tumor Resection. World J Surg 47, 2542–2553 (2023). https://doi.org/10.1007/s00268-023-07068-4

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