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Glasgow Prognostic Score Predicts Outcome After Surgical Resection of Gallbladder Cancer

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Abstract

Background

Systemic inflammation as evidenced by the Glasgow prognostic score (GPS) predicts cancer-specific survival in various types of cancer. The aim of this study was to evaluate the significance of GPS in therapeutic outcome after surgical resection of gallbladder cancer.

Methods

The subjects were 51 patients who underwent surgical resection for gallbladder cancer. For the assessment of systemic inflammatory response using the GPS, patients were classified into three groups: patients with normal albumin (≥3.5 g/dl) and normal C-reactive protein (CRP) (≤1.0 mg/dl) as GPS 0 (n = 38), those with low albumin (<3.5 g/dl) or elevated CRP (>1.0 mg/dl) as GPS 1 (n = 8), and those with low albumin (<3.5 g/dl) and elevated CRP (>1.0 mg/dl) as GPS 2 (n = 5). We retrospectively investigated the relation between patient characteristics including GPS, and disease-free as well as overall survival.

Results

In disease-free survival, advanced tumor stage based on pathology (p = 0.006), positive lymph node metastasis (p = 0.001), and GPS 1 or 2 (p = 0.006) were independent predictors of cancer recurrence in multivariate analysis. In overall survival, positive lymph node metastasis (p = 0.002) and GPS 1 or 2 (p = 0.032) were independent predictors of poor patient outcome in multivariate analyses.

Conclusion

The GPS in patients with gallbladder cancer is an independent prognostic predictor after surgical resection.

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Acknowledgments

We thank Dr. Matsushima (Division of Clinical Epidemiology, Jikei University School of Medicine) for his contributions in statistical analyses.

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Authors and Affiliations

  1. Department of Surgery, Jikei University School of Medicine, 3-25-8, Nishi-Shinbashi, Minato-ku, Tokyo, 105-8461, Japan

    Hiroaki Shiba, Takeyuki Misawa, Yuki Fujiwara, Yasuro Futagawa, Kenei Furukawa, Koichiro Haruki, Ryota Iwase, Tomonori Iida & Katsuhiko Yanaga

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  1. Hiroaki Shiba
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  2. Takeyuki Misawa
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  3. Yuki Fujiwara
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  4. Yasuro Futagawa
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  5. Kenei Furukawa
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  6. Koichiro Haruki
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  7. Ryota Iwase
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  8. Tomonori Iida
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  9. Katsuhiko Yanaga
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Correspondence to Hiroaki Shiba.

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Shiba, H., Misawa, T., Fujiwara, Y. et al. Glasgow Prognostic Score Predicts Outcome After Surgical Resection of Gallbladder Cancer. World J Surg 39, 753–758 (2015). https://doi.org/10.1007/s00268-014-2844-0

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  • DOI: https://doi.org/10.1007/s00268-014-2844-0

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