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EBV-Positive Diffuse Large B-Cell Lymphoma in Association with Polyurethane Textured Breast Implants: Case Report and Literature Overview

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Abstract

Objective

Lymphomas associated with breast implants are mostly of the T-cell type which typically present as a late-onset seroma or palpable mass adjacent to the implant. Primary lymphomas of the breast, in the absence of breast implants, are mostly of the B-cell type. However, we present a case of an Epstein-Barr virus-positive diffuse large B-cell lymphoma in a patient with polyurethane textured implants.

Case

A 75-year-old woman presented with a sudden onset of swelling in her right breast. Her medical history revealed a unilateral mastectomy at the age of 48 for an invasive ductal adenocarcinoma in her left breast. Reconstruction was performed using bilateral McGhan style 150 implants. Nine years later, she was diagnosed with Baker IV capsular contracture and bilateral rupture, as seen on magnetic resonance imaging. A complete capsulectomy with implant change (Polytech, Replicon® SL HP) and mastopexy on the right was performed. Given her history and the sudden onset of swelling, the situation was concerning. Ultrasound showed a large mass in contact with the implant and an effusion around it. After mastectomy with explantation and capsulectomy, she was diagnosed with an Epstein-Barr virus-associated diffuse large B-cell lymphoma (DLBCL) of the capsule in association with textured breast implants.

Conclusion

We report the first case of polyurethane textured implant association with the rare entity of EBV+ DLBCL. Our aim is to renew awareness of the clinical significance of late periprosthetic seroma and highlight the need for documenting all cases to advance our understanding of breast implant-associated lymphoma.

Level of Evidence III

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Authors and Affiliations

  1. Department of Plastic, Reconstructive and Aesthetic surgery, AZ Sint-Jan, Ruddershove 10, 8000, Brugges, Belgium

    Sam Brondeel, Fabrice Rogge, Edward De Wolf, Fien Decuypere & Bob Casaer

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  1. Sam Brondeel
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  2. Fabrice Rogge
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  3. Edward De Wolf
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Correspondence to Bob Casaer.

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Brondeel, S., Rogge, F., De Wolf, E. et al. EBV-Positive Diffuse Large B-Cell Lymphoma in Association with Polyurethane Textured Breast Implants: Case Report and Literature Overview. Aesth Plast Surg 47, 1274–1278 (2023). https://doi.org/10.1007/s00266-023-03377-0

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