Abstract
Background
Scars are inevitable results of surgical procedures, and prevention of them is still a major problem in the field of cosmetic surgery. Although various studies have been performed on botulinum toxin-A (BoNT‐A) injection for the prevention of hypertrophic scars, the exact mechanism remains unclear.
Methods
This prospective, double-blinded, randomized study was performed on 19 patients who underwent mammoplasty and abdominoplasty surgery in Razi Hospital from October 2018 to December 2019. Single session of treatment was performed, where XEOMIN was allocated to one half of the scar and 0.9% saline to the control half. 3 and 6 months later, scars were assessed using the modified Stony Brook Scar Evaluation Scale (SBSES).
Results
In total, 19 patients who completed the study were analyzed. mSBSES at the third month (P value < 0.001; 3.34 ± 1.59 vs 1.5 ± 1.36) and the sixth month (P value < 0.001; 4.89 ± 1.83 vs 2.39 ± 1.82) showed a significant difference between the treatment and control groups. In the subset analysis, there was significant difference between BoNT-A and control in all four items including width, height, color, and scar visibility at months 3 and 6, and the BoNT-A-treated sides had higher scores in all items.
Conclusion
BoNT-A has a significant effect on scar prevention due to mammoplasty and abdominoplasty compared to placebo and results in decreased erythema, height, width and reduces incision line visibility. Moreover, its effect increases significantly over time from months 3 to 6.
Level of Evidence II
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Acknowledgement
This research has been supported by Tehran University of Medical Sciences and Health Services (97-01-30-38098).
Funding
Funding was provided by Tehran University of Medical Sciences (Grant No. 97-01-30-38098).
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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. The study was reviewed and approved by the Institutional Review board of Tehran University of Medical Sciences (IR.TUMS.MEDICINE.REC.1397.068).
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Patients were informed about the study protocol, and informed consent was obtained from all participants.
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Abedini, R., Mehdizade Rayeni, N., Haddady Abianeh, S. et al. Botulinum Toxin Type A Injection for Mammoplasty and Abdominoplasty Scar Management: A Split-Scar Double-Blinded Randomized Controlled Study. Aesth Plast Surg 44, 2270–2276 (2020). https://doi.org/10.1007/s00266-020-01916-7
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DOI: https://doi.org/10.1007/s00266-020-01916-7