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Cell-Assisted Lipotransfer for Cosmetic Breast Augmentation: Supportive Use of Adipose-Derived Stem/Stromal Cells

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Abstract

Background

Lipoinjection is a promising treatment but has some problems, such as unpredictability and a low rate of graft survival due to partial necrosis.

Methods

To overcome the problems with lipoinjection, the authors developed a novel strategy known as cellassisted lipotransfer (CAL). In CAL, autologous adiposederived stem (stromal) cells (ASCs) are used in combination with lipoinjection. A stromal vascular fraction (SVF) containing ASCs is freshly isolated from half of the aspirated fat and recombined with the other half. This process converts relatively ASC-poor aspirated fat to ASC-rich fat. This report presents the findings for 40 patients who underwent CAL for cosmetic breast augmentation.

Results

Final breast volume showed augmentation by 100 to 200 ml after a mean fat amount of 270 ml was injected. Postoperative atrophy of injected fat was minimal and did not change substantially after 2 months. Cyst formation or microcalcification was detected in four patients. Almost all the patients were satisfied with the soft and natural-appearing augmentation.

Conclusions

The preliminary results suggest that CAL is effective and safe for soft tissue augmentation and superior to conventional lipoinjection. Additional study is necessary to evaluate the efficacy of this technique further.

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Authors and Affiliations

  1. Department of Plastic Surgery, University of Tokyo School of Medicine, 7-3-1 Hongo, Bunkyo-ku, 113-8655, Tokyo, Japan

    Kotaro Yoshimura & Noriyuki Aoi

  2. Cellport Clinic Yokohama, Yokohama Excellent III Building 2F, 3-35, Minami-nakadori, Naka-ku, Yokohama, 231-0006, Kanagawa, Japan

    Katsujiro Sato

  3. Department of Plastic Surgery, Kyorin University School of Medicine, 6-20-2 Shinkawa, Mitaka-shi, 181-8611, Tokyo, Japan

    Masakazu Kurita & Kiyonori Harii

  4. Ritz Cosmetic Surgery Clinic Tokyo, Meguro Toho Building 8F, 3-1-7, Kamiosaki, Shinagawa-ku, 141-0021, Tokyo, Japan

    Toshitsugu Hirohi

Authors
  1. Kotaro Yoshimura
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  2. Katsujiro Sato
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  3. Noriyuki Aoi
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  4. Masakazu Kurita
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  5. Toshitsugu Hirohi
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  6. Kiyonori Harii
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Corresponding author

Correspondence to Kotaro Yoshimura.

Additional information

This article is being reprinted for ISAPS 50th Anniversary Special Issue.

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Yoshimura, K., Sato, K., Aoi, N. et al. Cell-Assisted Lipotransfer for Cosmetic Breast Augmentation: Supportive Use of Adipose-Derived Stem/Stromal Cells. Aesth Plast Surg 44, 1258–1265 (2020). https://doi.org/10.1007/s00266-020-01819-7

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  • DOI: https://doi.org/10.1007/s00266-020-01819-7

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