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Breast-Conserving Surgery with Immediate Autologous Fat Grafting Reconstruction: Oncologic Outcomes

  • Original Article
  • Breast Surgery
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Abstract

Introduction

Autologous fat grafting (AFG; lipofilling, lipografting) has been used in delayed breast reconstruction. Recently, it has also been investigated as an alternative for immediate reconstruction in patients submitted to breast-conserving surgery (BCS). Although good aesthetic results have been reported, the oncologic safety of the procedure remains under investigation. This article aims to assess oncologic outcomes of patients submitted to BCS with immediate AFG reconstruction.

Methods

This study consisted of 65 patients undergoing BCS with AFG between January 2010 and January 2017. They were closely followed after surgery for a median period of 40.8 months. Locoregional and systemic recurrences were the primary endpoints of this study.

Results

Ten patients developed cancer recurrence (15.4%). The median time for recurrence was 58.9 months. Only two patients presented locoregional recurrence (LRR) (3.07%). Five patients had systemic recurrence (7.69%), and three had both systemic and LRR (4.61%). Median disease-free survival (DFS) was 42.2 months, and overall survival (OV) was 44.3 months. Recurrences were significantly associated with the number of metastatic axillary lymph nodes detected.

Conclusion

Oncologic outcomes of immediate AFG are similar to the results previously reported in BCS without AFG. Locoregional and systemic recurrences are associated with the presence of axillary metastases.

Level of Evidence IV

This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.

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Authors and Affiliations

  1. Postgraduate Program in Gynecology and Obstetrics, Federal University of Rio Grande do Sul, Rua Ramiro Barcelos, no. 2400 2º andar, Porto Alegre, RS, CEP 90035003, Brazil

    Jorge Villanova Biazus, Camile Cesa Stumpf & Andrea Pires Damin

  2. Division of Breast Surgery, Hospital de Clinicas de Porto Alegre, Federal University of Rio Grande do Sul, Rua Ramiro Barcelos no. 2350, room 600 C, Porto Alegre, RS, CEP 9005903, Brazil

    Jorge Villanova Biazus, Marcia Portela Melo, Angela Erguy Zucatto, Rodrigo Cericatto, Jose Antonio Cavalheiro & Andrea Pires Damin

Authors
  1. Jorge Villanova Biazus
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  2. Camile Cesa Stumpf
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  3. Marcia Portela Melo
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  4. Angela Erguy Zucatto
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  5. Rodrigo Cericatto
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  6. Jose Antonio Cavalheiro
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  7. Andrea Pires Damin
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Corresponding author

Correspondence to Andrea Pires Damin.

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Conflict of interest

The authors declare that they have no conflict of interest.

Ethical Approval

The present work was performed upon approval by the Ethics and Scientific Committee of the Clinical Hospital of Porto Alegre, Federal University of Rio Grande do Sul. Informed consent was obtained from all patients before being enrolled in the study. All procedures performed in this study were in accordance with the ethical standards of the institutional and national research committee and with the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards.

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Biazus, J.V., Stumpf, C.C., Melo, M.P. et al. Breast-Conserving Surgery with Immediate Autologous Fat Grafting Reconstruction: Oncologic Outcomes. Aesth Plast Surg 42, 1195–1201 (2018). https://doi.org/10.1007/s00266-018-1155-5

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  • DOI: https://doi.org/10.1007/s00266-018-1155-5

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