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Risk factors of venous thromboembolism in patients with benign and malignant musculoskeletal tumors: a dual database analysis

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Abstract

Purpose

Venous thromboembolism (VTE) is a potentially life-threatening condition associated with both orthopaedic surgery and tumour growth. In this study, we identify risk factors associated with VTE in patients with musculoskeletal tumours using two national datasets.

Methods

The ACS-NSQIP and NIS databases were queried for patients undergoing surgery with a diagnosis of benign or malignant musculoskeletal tumours. Chi-square and binary logistic regression analyses were used to determine risk factors for VTE.

Results

The incidence of VTE was 2% in both databases. Patients with malignant tumours, those with tumours of the pelvis, sacrum, or coccyx, obesity, arrhythmias, paralysis, metastatic disease, coagulopathy, and recent weight loss were at increased risk for VTE. In patients with benign tumours, those who were African American, those with tumours of the pelvis, sacrum, or coccyx, diabetes, anaemia, and coagulopathy were at increased risk of VTE.

Conclusions

Patients with malignant or benign lesion are at greater risk of VTE if they are age 30 and over, of the African American population, or with tumors of the pelvis/sacrum/coccyx, or any of the following comorbidities: pulmonary disease, paralysis, other neurological disorders, or coagulopathy.

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Authors and Affiliations

  1. Department of Orthopaedics, Rutgers New Jersey Medical School, 140 Bergen Street, ACC D1610, Newark, NJ, 07103, USA

    Dominick V. Congiusta, Kamil M. Amer, Jennifer Thomson, Joseph Ippolito, Kathleen S. Beebe & Joseph Benevenia

Authors
  1. Dominick V. Congiusta
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  2. Kamil M. Amer
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  3. Jennifer Thomson
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  4. Joseph Ippolito
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  5. Kathleen S. Beebe
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  6. Joseph Benevenia
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Contributions

Dominick V. Congiusta and Kamil M. Amer: project conception, statistics, and manuscript preparation. Jennifer Thomson, Joseph Ippolito, Kathleen S. Beebe, and Joseph Benevenia: project conception and manuscript preparation

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Correspondence to Dominick V. Congiusta.

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Congiusta, D.V., Amer, K.M., Thomson, J. et al. Risk factors of venous thromboembolism in patients with benign and malignant musculoskeletal tumors: a dual database analysis. International Orthopaedics (SICOT) 44, 2147–2153 (2020). https://doi.org/10.1007/s00264-020-04707-6

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  • DOI: https://doi.org/10.1007/s00264-020-04707-6

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