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Multimodality imaging features of small bowel cancers complicating Crohn’s disease: a pictorial review

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Abstract

Patients with Crohn’s disease (CD) are at increased risk of developing small bowel cancer, since chronic inflammation may trigger the histopathological sequence that begins from low-grade dysplasia of the intestinal epithelium and may eventually lead to malignant transformation. Owing to their location in a portion of the gastrointestinal tract which is not easily accessible to conventional endoscopic techniques, the detection of CD-related small bowel cancers is still a clinical challenge. The radiological features of CD-related small bowel adenocarcinoma (SBA) in patients with CD have been described in some previous studies, including its appearance in both CT and MRI examinations. Radiological signs of active or fibrostenotic CD may be intermixed with those suggesting the presence of CD-related SBA. In CT studies, the most relevant findings consistent with malignant transformation are the presence of a stricture with irregular asymmetric thickening of small bowel walls, loss of mural stratification, and moderate enhancement after intravenous administration of iodinated contrast media, in association with enlarged adjacent mesenteric lymph nodes. Many of the CD-related SBA features that can be observed on CT imaging are similar to those detectable by MRI. This latter modality provides the additional value of the functional characterization of small bowel strictures, thereby helping to distinguish between inflammatory, fibrotic, and malignant stenosis in the setting of active CD. Positron Emission Tomography (PET)/CT enables the metabolic assessment of enlarged mesenteric lymph nodes, and PET/MRI fusion imaging can incorporate morphological, functional and metabolic information into a single set of imaging data, thus overcoming the limitations of the separate assessment of each individual modality. Owing to the low incidence and prevalence of this long-term complication of CD, we believe that a detailed multimodality pictorial essay on this topic, also including the PET-CT and fusion imaging documentation of some cases, would be useful to the medical literature.

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Funding

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Author information

Author notes

  1. Francesco Paparo and Nicola Panvini have contributed equally to this work.

Authors and Affiliations

  1. Diagnostic Imaging Unit, E.O. Ospedali Galliera, Mura Delle Cappuccine 14, 16128, Genoa, Italy

    Francesco Paparo, Nicola Panvini, Maria Pigati, Enrico Francesco Melani & Lucio Molini

  2. Gastroenterology Unit, E.O. Ospedali Galliera, Mura Delle Cappuccine 14, 16128, Genoa, Italy

    Amedeo Montale

  3. Pathology Unit, E.O. Ospedali Galliera, Mura Delle Cappuccine 14, 16128, Genoa, Italy

    Eugenio Marinaro

  4. Nuclear Medicine Unit, E.O. Ospedali Galliera, Mura Delle Cappuccine 14, 16128, Genoa, Italy

    Arnoldo Piccardo

Authors
  1. Francesco Paparo
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  2. Nicola Panvini
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  3. Amedeo Montale
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  4. Maria Pigati
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  5. Eugenio Marinaro
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  6. Enrico Francesco Melani
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  7. Arnoldo Piccardo
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  8. Lucio Molini
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Contributions

FP, NP conceptualized the study; EM; MP, AM helped in literature search and data collection; FP, NP, MP were involved in writing—original draft preparation; FP, NP, AM, EM, EFM, AP, LM helped in writing—review and editing; FP, NP, LM supervised the study.

Corresponding author

Correspondence to Nicola Panvini.

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Paparo, F., Panvini, N., Montale, A. et al. Multimodality imaging features of small bowel cancers complicating Crohn’s disease: a pictorial review. Abdom Radiol (2024). https://doi.org/10.1007/s00261-024-04201-2

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  • DOI: https://doi.org/10.1007/s00261-024-04201-2

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