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T1 mapping in evaluation of clinicopathologic factors for rectal adenocarcinoma

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Abstract

Objective

T1 mapping has been increasingly applied in the study of tumor. The purpose of this study was to evaluate the value of T1 mapping in evaluating clinicopathologic factors for rectal adenocarcinoma.

Materials and methods

Eighty-six patients with rectal adenocarcinoma confirmed by surgical pathology who underwent preoperative pelvic MRI were retrospectively analyzed. High-resolution T2-weighted imaging (T2WI), T1 mapping, and diffusion-weighted imaging (DWI) were performed. T1 and apparent diffusion coefficient (ADC) parameters were compared among different associated tumor markers, tumor grades, stages, and structure invasion statuses. A receiver operating characteristic (ROC) analysis was estimated.

Results

T1 value showed significant difference between high- and low-grade tumors ([1531.5 ± 84.7 ms] vs. [1437.1 ± 80.3 ms], P < 0.001). T1 value was significant higher in positive than in negative perineural invasion ([1495.7 ± 89.2 ms] vs. [1449.4 ± 88.8 ms], P < 0.05). No significant difference of T1 or ADC was observed in different CEA, CA199, T stage, N stage, lymphovascular invasions, extramural vascular invasion (EMVI), and circumferential resection margin (CRM) (P > 0.05). The AUC under ROC curve of T1 value were 0.796 in distinguishing high- from low-grade rectal adenocarcinoma. The AUC of T1 value in distinguishing perineural invasion was 0.637.

Conclusion

T1 value was helpful in assessing pathologic grade and perineural invasion correlated with rectal cancer.

Graphical abstract

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Data availability

All data generated or analyzed during this study are included in this published article. The datasets are available from the corresponding author on reasonable request.

Abbreviations

ADC:

Apparent diffusion coefficient

AUC:

Area under the curve

AJCC:

American Joint Committee on Cancer

CRM:

Circumferential resection margin

CI:

Confidence interval

DWI:

Diffusion-weighted imaging

EMVI:

Extramural vascular invasion

MRI:

Magnetic resonance imaging

ROC:

Receiver operating characteristic

ROI:

Region of interest

ss-EPI:

Single-shot echo plane imaging

TNM:

Tumor-node-metastasis

T2W:

T2 weighted

TSE:

Turbo spin echo

TA:

Acquisition time

TE:

Echo time

TR:

Repetition time

WHO:

World Health Organization

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Acknowledgements

The authors acknowledge all the colleagues and participants in this hospital for their supports, especially the Department of MRI, the First Affiliated Hospital of Zhengzhou University.

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Authors and Affiliations

  1. Department of MRI, The First Affiliated Hospital of Zhengzhou University, No. 1, Jianshe Dong Road, Zhengzhou, 450052, China

    Juan Li, Peisi Kou, Yunfei Xiao, Hongrui Jin, Yong Zhang & Jingliang Cheng

  2. Advanced Technical Support, Philips Healthcare, Beijing, China

    Liangjie Lin

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  1. Juan Li
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Contributions

JL, YX, and HJ made contribution to collecting patients. JL, LL, and PK made data analysis and interpretation. JL, PK, YZ, and JC were major contributors. All authors made a substantial contribution to researching data, discussion of content, and reviewing and editing manuscript before submission. All authors read and approved the final manuscript.

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Correspondence to Juan Li.

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The authors declare that they have no competing interests.

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Ethical approval

This study was approved by our institutional ethics committee.

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Li, J., Kou, P., Lin, L. et al. T1 mapping in evaluation of clinicopathologic factors for rectal adenocarcinoma. Abdom Radiol 49, 279–287 (2024). https://doi.org/10.1007/s00261-023-04045-2

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