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Primary sclerosing cholangitis: review for radiologists

  • Special Section: Benign Biliary
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Abstract

Primary sclerosing cholangitis is a rare chronic inflammatory disease affecting the bile ducts, which can eventually result in bile duct strictures, cholestasis and cirrhosis. Patients are often asymptomatic but may present with clinical features of cholestasis. Imaging plays an important role in the diagnosis and management. This review covers the pathophysiology, clinical features, imaging findings as well as methods of surveillance and post-transplant appearance.

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Acknowledgements

Dr. Venkatesh acknowledges support from NIH R01Grant EB001981 and U.S. Department of Defense Grant W81XWH-19-1-0583-01.

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Authors and Affiliations

  1. Department of Radiology, University of Pennsylvania Health System, 1 Silverstein, 3400 Spruce Street, Philadelphia, PA, USA

    Matthew A. Morgan & Karthik M. Sundaram

  2. Radiology and Medical Imaging, University of Virginia Health, 1215 Lee Street, Charlottesville, VA, USA

    Rachita Khot

  3. Mallinckrodt Institute of Radiology, Washington University School of Medicine, 510 S. Kingshighway Blvd, Campus Box 8131, Saint Louis, MO, USA

    Daniel R. Ludwig

  4. Department of Radiology, University of Kentucky, 800 Rose Street, Room HX 313B, Lexington, KY, 40536-0293, USA

    Rashmi T. Nair

  5. Medical College of Georgia at Augusta University, 1120 15th street BA -1411, Augusta, GA, 30912, USA

    Pardeep K. Mittal

  6. The University of Texas MD Anderson Cancer Center, 1400 Pressler St., Unit 1473, Houston, TX, 77030, USA

    Dhakshina M. Ganeshan

  7. Abdominal Imaging, Department of Radiology, Mayo Clinic, Rochester, MN, 55905, USA

    Sudhakar K. Venkatesh

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  1. Matthew A. Morgan
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Morgan, M.A., Khot, R., Sundaram, K.M. et al. Primary sclerosing cholangitis: review for radiologists. Abdom Radiol 48, 136–150 (2023). https://doi.org/10.1007/s00261-022-03655-6

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