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Retrospective observation of the efficacy and safety of prostatic artery embolization combined with transurethral resection of the prostate and simple transurethral resection of the prostate in the treatment of large (> 100 mL) benign prostatic hyperplasia

  • Interventional Radiology
  • Published:
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Abstract

Purpose

To retrospectively compare the efficacy and safety of prostatic artery embolization (PAE) combined with transurethral resection of the prostate (TURP) and simple TURP in treating large (> 100 mL) benign prostatic hyperplasia (BPH).

Methods

We retrospectively analyzed the clinical data of 13 and 17 patients with large BPH who underwent TURP and PAE + TURP, respectively, from January 2016 to January 2020. The changes in various indices before and after surgery were compared between the two groups.

Results

In the PAE + TURP group, the operation time (OT), intraoperative blood loss (BL), postoperative bladder flushing time (PBFT), and postoperative catheter retention time (PCRT) were lower, and the speed of the excised lesion (SEL) was higher than that in the TURP group (P < 0.05). Following-up for 12 months, the prostatic volume (PV), maximum urinary flow rate (Qmax), postvoid residual volume (PVR), International Prostate Symptom Score (IPSS), quality of life (QoL) score, total prostate-specific antigen (T-PSA), and free prostate-specific antigen (F-PSA) in each group improved as compared to before the surgery (P < 0.05), and the above improved indicators, IPSS ratio, and obstructive symptoms in the PAE + TURP group were higher than those in the TURP group (P < 0.05). The incidence of postoperative complications in the PAE + TURP group was lower than that in the TURP group. We obtained the pathological picture of a prostate biopsy after PAE for the first time.

Conclusion

Compared to TURP alone, PAE + TURP should be promoted, because of its greater efficacy and safety in treating large BPH and fewer post-surgical complications.

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Funding

This study was supported by the Fujian Province Natural Science Fund Project (2020J011096, 2020J011064) and the Special Research Foundation of Fujian Provincial Department of Finance (No. [2020]822 #), China.

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Author notes

  1. Yi Tang, Ruo-li Wang and Dan-dan Ruan have contributed equally to this work

Authors and Affiliations

  1. Shengli Clinical Medical College of Fujian Medical University, Fuzhou, 350001, China

    Yi Tang, Ruo-li Wang, Dan-dan Ruan, Xin Chen, Yan-feng Zhou, Shao-jie Wu, Sen‑lin Cai, Jian-hui Zhang, Feng-guang Yang, Jie-wei Luo & Zhu-ting Fang

  2. Department of Interventional Radiology, Fujian Provincial Hospital, Fuzhou, 350001, China

    Yi Tang, Yan-feng Zhou, Shao-jie Wu, Sen‑lin Cai & Zhu-ting Fang

  3. Department of Traditional Chinese Medicine, Fujian Provincial Hospital, Fuzhou, 350001, China

    Jie-wei Luo

  4. Department of Urology, Fujian Provincial Hospital, Fuzhou, 350001, China

    Feng-guang Yang

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  1. Yi Tang
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Contributions

YT, RLW, DDR, XC, and YFZ performed the acquisition, analysis, and interpretation of the clinical data; YT, RLW, and DDR drafted the manuscript; FGY provided critical revision of the manuscript; ZTF and JWL designed and supervised the study.

Corresponding authors

Correspondence to Jie-wei Luo or Zhu-ting Fang.

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The need for approval was waived the local ethical committees as data were collected retrospectively and reported anonymously. All participants signed informed consent documentation.

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Informed consent was obtained from all individual participants included in the study.

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Tang, Y., Wang, Rl., Ruan, Dd. et al. Retrospective observation of the efficacy and safety of prostatic artery embolization combined with transurethral resection of the prostate and simple transurethral resection of the prostate in the treatment of large (> 100 mL) benign prostatic hyperplasia. Abdom Radiol 46, 5746–5757 (2021). https://doi.org/10.1007/s00261-021-03258-7

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