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Can whole-tumor radiomics-based CT analysis better differentiate fat-poor angiomyolipoma from clear cell renal cell caricinoma: compared with conventional CT analysis?

  • Kidneys, Ureters, Bladder, Retroperitoneum
  • Published:
Abdominal Radiology Aims and scope Submit manuscript

Abstract

Purpose

This study aimed to discriminate fat-poor angiomyolipoma (fp-AML) from clear cell renal cell carcinoma (ccRCC) by constructing radiomics-based logistic classifiers in comparison with conventional computed tomography (CT) analysis at three CT phases.

Materials and methods

Twenty-two fp-AML patients and 62 ccRCC patients who were pathologically identified were enrolled in this study, and underwent three-phase (unenhanced phase, UP; corticomedullary phase, CMP; nephrographic phase, NP) CT examinations. Whole-tumor regions of interest (ROIs) were contoured in ITK software by two radiologists. Radiomic features were dimensionally reduced by means of ANOVA + MW, correlation analysis, and LASSO. Four radiomics logistic classifiers including the UP group, CMP group, NP group, and sum group were built, and the radiomic scores (rad-scores) were calculated. After collecting the qualitative and quantitative conventional CT characteristics, the conventional CT analysis logistic classifier and the radiomics-based logistic classifier were constructed. The receiver operating characteristic curve (ROC) was constructed to evaluate the validity of each classifier.

Results

The area under curve (AUC) of the conventional CT analysis logistic classifier including angular interface, cyst degeneration, and pseudocapsule was 0.935 (95% CI 0.860–0.977). Regarding logistic classifiers for radiomics analysis, the AUCs of the UP group were 0.950 (95% CI 0.895–1.000) and 0.917 (95% CI 0.801–1.000) in the training set and testing set, respectively, which were higher than those of the CMP and NP groups. The AUCs of the sum group were observed to be the highest. The top three selected features for the UP and sum groups belonged to GLCM parameters and histogram parameters. The radiomics-based logistic classifier encompassed cyst degeneration, pseudocapsule, and sum rad-score, and the AUC of the model was 0.988 (95% CI 0.935–1.000).

Conclusion

Whole-tumor radiomics-based CT analysis is superior to conventional CT analysis in the differentiation of fp-AML from ccRCC. Cyst degeneration, pseudocapsule, and sum rad-score are the most significant factors. The radiomics analysis of the UP group shows a higher AUC than that of the CMP and NP groups.

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Authors and Affiliations

  1. Department of Radiology, Zhejiang Provincial People’s Hospital, People’s Hospital of Hangzhou Medical College, 310000, Hangzhou, China

    Yanqing Ma, Fang Cao & Xiren Xu

  2. Department of Neurosurgery, Shaoxing City Keqiao District Hospital of Traditional Chinese Medicine, 312000, Shaoxing, China

    Weijun Ma

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  1. Yanqing Ma
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  2. Fang Cao
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Correspondence to Yanqing Ma.

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Ma, Y., Cao, F., Xu, X. et al. Can whole-tumor radiomics-based CT analysis better differentiate fat-poor angiomyolipoma from clear cell renal cell caricinoma: compared with conventional CT analysis?. Abdom Radiol 45, 2500–2507 (2020). https://doi.org/10.1007/s00261-020-02414-9

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  • DOI: https://doi.org/10.1007/s00261-020-02414-9

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