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Diffusion-weighted whole-body imaging with background body signal suppression/T2 image fusion and positron emission tomography/computed tomography of upper gastrointestinal cancers

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Abstract

Purpose

Diffusion-weighted whole-body imaging with background body signal suppression/T2 image fusion (DWIBS/T2) strongly contrasts cancerous tissue against background healthy tissues. Positron emission tomography/computed tomography (PET/CT) applies the uptake of 18-fluorodeoxyglucose in the diagnosis of cancer. Our aim was to compare DWIBS/T2 and PET/CT in patients with upper gastrointestinal cancers.

Methods

Patient records, including imaging results from July 2012 to March 2015, were analyzed retrospectively. Four men (age, 72.5 ± 5.3 years) and ten women (age, 71.6 ± 4.0 years) were enrolled in this study. The numbers of patients with esophageal cancer, gastric cancer, gastrointestinal stromal tumor, and duodenal cancer were one, eight, three, and two, respectively.

Results

Six out of eight patients with gastric cancer had positive results on both DWIBS/T2 and PET/CT. The diameter and depth of invasion of gastric cancer was larger in patients with positive DWIBS/T2 and PET/CT findings than those with negative findings. These results suggested that patients with gastric cancer with larger pixel numbers might tend to show positive results with DWIBS/T2.

Conclusions

DWIBS/T2 and PET/CT have similar sensitivity for the diagnosis of upper gastrointestinal cancer. The diameter and depth of invasion affected the detectability of gastric cancer.

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References

  1. Allum WH, Blazeby JM, Griffin SM, et al. (2011) Guidelines for the management of oesophageal and gastric cancer. Gut 60(11):1449–1472. doi:10.1136/gut.2010.228254

    Article  CAS  PubMed  Google Scholar 

  2. Labianca R, Nordlinger B, Beretta GD, et al. (2013) Early colon cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol 24(Suppl 6):vi64–vi72. doi:10.1093/annonc/mdt354

    Article  PubMed  Google Scholar 

  3. Jurgensen C, Brand J, Nothnagel M, et al. (2013) Prognostic relevance of gastric cancer staging by endoscopic ultrasound. Surg Endosc 27(4):1124–1129. doi:10.1007/s00464-012-2558-z

    Article  PubMed  Google Scholar 

  4. Dai T, Popa E, Shah MA (2014) The role of (1)(8)F-FDG PET imaging in upper gastrointestinal malignancies. Curr Treat Options Oncol 15(3):351–364. doi:10.1007/s11864-014-0301-9

    Article  PubMed  Google Scholar 

  5. Kato H, Kuwano H, Nakajima M, et al. (2002) Comparison between positron emission tomography and computed tomography in the use of the assessment of esophageal carcinoma. Cancer 94(4):921–928. doi:10.1002/cncr.10330

    Article  PubMed  Google Scholar 

  6. Komori T, Narabayashi I, Matsumura K, et al. (2007) 2-[Fluorine-18]-fluoro-2-deoxy-d-glucose positron emission tomography/computed tomography versus whole-body diffusion-weighted MRI for detection of malignant lesions: initial experience. Ann Nucl Med 21(4):209–215. doi:10.1007/s12149-007-0010-6

    Article  PubMed  Google Scholar 

  7. Takahara T, Imai Y, Yamashita T, et al. (2004) Diffusion weighted whole body imaging with background body signal suppression (DWIBS): technical improvement using free breathing, STIR and high resolution 3D display. Radiat Med 22(4):275–282

    PubMed  Google Scholar 

  8. Sehy JV, Ackerman JJ, Neil JJ (2002) Apparent diffusion of water, ions, and small molecules in the Xenopus oocyte is consistent with Brownian displacement. Magn Reson Med 48(1):42–51. doi:10.1002/mrm.10181

    Article  CAS  PubMed  Google Scholar 

  9. Koike N, Cho A, Nasu K, et al. (2009) Role of diffusion-weighted magnetic resonance imaging in the differential diagnosis of focal hepatic lesions. World J Gastroenterol 15(46):5805–5812

    Article  PubMed Central  PubMed  Google Scholar 

  10. Kwee TC, Takahara T, Ochiai R, Nievelstein RA, Luijten PR (2008) Diffusion-weighted whole-body imaging with background body signal suppression (DWIBS): features and potential applications in oncology. Eur Radiol 18(9):1937–1952. doi:10.1007/s00330-008-0968-z

    Article  PubMed Central  PubMed  Google Scholar 

  11. Ohno Y, Koyama H, Onishi Y, et al. (2008) Non-small cell lung cancer: whole-body MR examination for M-stage assessment-utility for whole-body diffusion-weighted imaging compared with integrated FDG PET/CT. Radiology 248(2):643–654. doi:10.1148/radiol.2482072039

    Article  PubMed  Google Scholar 

  12. Fischer MA, Nanz D, Hany T, et al. (2011) Diagnostic accuracy of whole-body MRI/DWI image fusion for detection of malignant tumours: a comparison with PET/CT. Eur Radiol 21(2):246–255. doi:10.1007/s00330-010-1929-x

    Article  PubMed  Google Scholar 

  13. Sommer G, Wiese M, Winter L, et al. (2012) Preoperative staging of non-small-cell lung cancer: comparison of whole-body diffusion-weighted magnetic resonance imaging and 18F-fluorodeoxyglucose-positron emission tomography/computed tomography. Eur Radiol 22(12):2859–2867. doi:10.1007/s00330-012-2542-y

    Article  PubMed  Google Scholar 

  14. Nechifor-Boila IA, Bancu S, Buruian M, et al. (2013) Diffusion weighted imaging with background body signal suppression/T2 image fusion in magnetic resonance mammography for breast cancer diagnosis. Chirurgia (Bucur) 108(2):199–205

    CAS  Google Scholar 

  15. Rutkowski P, Wozniak A, Debiec-Rychter M, et al. (2011) Clinical utility of the new American Joint Committee on Cancer staging system for gastrointestinal stromal tumors: current overall survival after primary tumor resection. Cancer 117(21):4916–4924. doi:10.1002/cncr.26079

    Article  PubMed  Google Scholar 

  16. Wang Y, Miller FH, Chen ZE, et al. (2011) Diffusion-weighted MR imaging of solid and cystic lesions of the pancreas. Radiographics 31(3):E47–E64. doi:10.1148/rg.313105174

    Article  PubMed  Google Scholar 

  17. Tanaka S, Ikeda K, Uchiyama K, et al. (2013) [18F]FDG uptake in proximal muscles assessed by PET/CT reflects both global and local muscular inflammation and provides useful information in the management of patients with polymyositis/dermatomyositis. Rheumatology (Oxford) 52(7):1271–1278. doi:10.1093/rheumatology/ket112

    Article  CAS  Google Scholar 

  18. Grabinska K, Pelak M, Wydmanski J, Tukiendorf A, d’Amico A (2015) Prognostic value and clinical correlations of 18-fluorodeoxyglucose metabolism quantifiers in gastric cancer. World J Gastroenterol 21(19):5901–5909. doi:10.3748/wjg.v21.i19.5901

    PubMed Central  CAS  PubMed  Google Scholar 

  19. Shinya S, Sasaki T, Nakagawa Y, et al. (2007) The usefulness of diffusion-weighted imaging (DWI) for the detection of gastric cancer. Hepatogastroenterology 54(77):1378–1381

    PubMed  Google Scholar 

  20. Liu S, He J, Guan W, et al. (2014) Preoperative T staging of gastric cancer: comparison of diffusion- and T2-weighted magnetic resonance imaging. J Comput Assist Tomogr 38(4):544–550. doi:10.1097/RCT.0000000000000090

    Article  PubMed  Google Scholar 

  21. Liu S, He J, Guan W, et al. (2014) Added value of diffusion-weighted MR imaging to T2-weighted and dynamic contrast-enhanced MR imaging in T staging of gastric cancer. Clin Imaging 38(2):122–128. doi:10.1016/j.clinimag.2013.12.001

    Article  CAS  PubMed  Google Scholar 

  22. Caivano R, Rabasco P, Lotumolo A, et al. (2014) Gastric cancer: The role of diffusion weighted imaging in the preoperative staging. Cancer Invest 32(5):184–190. doi:10.3109/07357907.2014.896014

    Article  CAS  PubMed  Google Scholar 

  23. Yamada A, Oguchi K, Fukushima M, Imai Y, Kadoya M (2006) Evaluation of 2-deoxy-2-[18F]fluoro-d-glucose positron emission tomography in gastric carcinoma: relation to histological subtypes, depth of tumor invasion, and glucose transporter-1 expression. Ann Nucl Med 20(9):597–604

    Article  CAS  PubMed  Google Scholar 

  24. Yun M (2014) Imaging of gastric cancer metabolism using 18 F-FDG PET/CT. J Gastric Cancer 14(1):1–6. doi:10.5230/jgc.2014.14.1.1

    Article  PubMed Central  PubMed  Google Scholar 

  25. Cayvarli H, Bekis R, Akman T, Altun D (2014) The role of 18F-FDG PET/CT in the evaluation of gastric cancer recurrence. Mol Imaging Radionucl Ther 23(3):76–83. doi:10.4274/mirt.83803

    Article  PubMed Central  PubMed  Google Scholar 

  26. Ulusan S, Koc Z (2009) Radiologic findings in malignant gastrointestinal stromal tumors. Diagn Interv Radiol 15(2):121–126

    PubMed  Google Scholar 

  27. Wong CS, Gong N, Chu YC, et al. (2012) Correlation of measurements from diffusion weighted MR imaging and FDG PET/CT in GIST patients: ADC versus SUV. Eur J Radiol 81(9):2122–2126. doi:10.1016/j.ejrad.2011.09.003

    Article  PubMed  Google Scholar 

  28. Yu MH, Lee JM, Baek JH, Han JK, Choi BI (2014) MRI features of gastrointestinal stromal tumors. AJR Am J Roentgenol 203(5):980–991. doi:10.2214/AJR.13.11667

    Article  PubMed  Google Scholar 

  29. Schmidt S, Dunet V, Koehli M, et al. (2013) Diffusion-weighted magnetic resonance imaging in metastatic gastrointestinal stromal tumor (GIST): a pilot study on the assessment of treatment response in comparison with 18F-FDG PET/CT. Acta Radiol 54(8):837–842. doi:10.1177/0284185113485732

    Article  PubMed  Google Scholar 

  30. Tomizawa M, Shinozaki F, Hasegawa R, et al. (2015) Factors affecting the detection of colorectal cancer and colon polyps on screening abdominal ultrasonography. Hepatogastroenterology 62(138):295–298

    PubMed  Google Scholar 

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Conflict of interest

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Author information

Authors and Affiliations

  1. Department of Gastroenterology, National Hospital Organization Shimoshizu Hospital, 934-5 Shikawatashi, Yotsukaido City, Chiba, 284-0003, Japan

    Minoru Tomizawa

  2. Department of Radiology, National Hospital Organization Shimoshizu Hospital, 934-5 Shikawatashi, Yotsukaido City, Chiba, 284-0003, Japan

    Fuminobu Shinozaki, Takafumi Sunaoshi, Aika Ozaki, Eriko Sugiyama, Akira Baba, Yoshiya Fukamizu & Satoshi Kagayama

  3. Department of Radiology, Diagnostic PET Imaging Center, Sannoh Hospital Medical Center, 166-2 Sannoh-cho Inage-ku, Chiba City, Chiba, 263-0002, Japan

    Yoshitaka Uchida & Katsuhiro Uchiyama

  4. Department of Molecular Pathology, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chuo-ku, Chiba City, 260-8670, Japan

    Kazunori Fugo & Takashi Kishimoto

  5. Department of Surgery, National Hospital Organization Shimoshizu Hospital, 934-5 Shikawatashi, Yotsukaido City, Chiba, 284-0003, Japan

    Rumiko Hasegawa & Yoshinori Shirai

  6. Department of Surgery, Seirei Sakura Citizen Hospital, 2-36-2 Ebaradai, Sakura City, Chiba, 285-8765, Japan

    Yuji Oshima & Naoto Koike

  7. Department of Surgery, National Hospital Organization Chiba Medical Center, 4-1-2 Tsubakimori, Chiba City, Chiba, 260-8606, Japan

    Yasuko Toshimitsu

  8. Department of Neurology, National Hospital Organization Shimoshizu Hospital, 934-5 Shikawatashi, Yotsukaido City, Chiba, 284-0003, Japan

    Yasufumi Motoyoshi

  9. Department of Rheumatology, National Hospital Organization Shimoshizu Hospital, 934-5 Shikawatashi, Yotsukaido City, Chiba, 284-0003, Japan

    Takao Sugiyama

  10. Department of Pediatrics, National Hospital Organization Shimoshizu Hospital, 934-5 Shikawatashi, Yotsukaido City, Chiba, 284-0003, Japan

    Shigenori Yamamoto

  11. Department of Neurosurgery, National Hospital Organization Shimoshizu Hospital, 934-5 Shikawatashi, Yotsukaido City, Chiba, 284-0003, Japan

    Naoki Ishige

Authors
  1. Minoru Tomizawa
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  2. Fuminobu Shinozaki
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  3. Yoshitaka Uchida
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  4. Katsuhiro Uchiyama
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  5. Kazunori Fugo
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  6. Takafumi Sunaoshi
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  7. Aika Ozaki
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  8. Eriko Sugiyama
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  9. Akira Baba
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  10. Yoshiya Fukamizu
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  11. Satoshi Kagayama
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  12. Rumiko Hasegawa
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  13. Yoshinori Shirai
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  14. Yuji Oshima
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  15. Naoto Koike
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  16. Yasuko Toshimitsu
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  17. Yasufumi Motoyoshi
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  18. Takao Sugiyama
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  19. Shigenori Yamamoto
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  20. Takashi Kishimoto
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  21. Naoki Ishige
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Corresponding author

Correspondence to Minoru Tomizawa.

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Tomizawa, M., Shinozaki, F., Uchida, Y. et al. Diffusion-weighted whole-body imaging with background body signal suppression/T2 image fusion and positron emission tomography/computed tomography of upper gastrointestinal cancers. Abdom Imaging 40, 3012–3019 (2015). https://doi.org/10.1007/s00261-015-0545-2

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  • DOI: https://doi.org/10.1007/s00261-015-0545-2

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