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2-[18F]FDG-PET/CT for early response and brain metabolic pattern assessment after CAR-T cell therapy in a diffuse large B cell lymphoma patient with ICANS

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References

  1. Crump M, Neelapu SS, Farooq U, Van Den Neste E, Kuruvilla J, Westin J, et al. Outcomes in refractory diffuse large B-cell lymphoma: results from the international SCHOLAR-1 study. Blood. 2017;130:1800–8. https://doi.org/10.1182/blood-2017-03-769620.

    Article  CAS  PubMed  Google Scholar 

  2. Cabanillas F, Shah B. Advances in diagnosis and management of diffuse large B-cell lymphoma. Clin Lymphoma Myeloma Leuk. 2017;17(12):783–96. https://doi.org/10.1016/j.clml.2017.10.007.

  3. Neelapu SS, Locke FL, Bartlett NL, et al. Axicabtagene ciloleucel CAR T-cell therapy in refractory large B-cell lymphoma. N Engl J Med. 2017;377:2531–44. https://doi.org/10.1056/NEJMoa1707447.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Rubin DB, Husain HD, Ali BA, Karen L, Sarah L, et al. Neurological toxicities associated with chimeric antigen receptor T-cell therapy. Brain. 2019;142(5):1334–48. https://doi.org/10.1093/brain/awz053.

    Article  PubMed  Google Scholar 

  5. Shah NN, Sarah JN, Drew AT, Michael DF, Wei-Ting H, Noelle F, et al. Early positron emission tomography/computed tomography as a predictor of response after CTL019 chimeric antigen receptor –T-cell therapy in B-cell non-hodgkin lymphomas. Cytotherapy. 2018;20(12):1415–8. https://doi.org/10.1016/j.jcyt.2018.10.003.

    Article  CAS  PubMed  Google Scholar 

  6. Ruff A, Hatcher JB, Austin RP, Esin CN, Mitchell EH, Sunita DN, et al. 18F-Fluorodeoxyglucose positron emission tomography/computed tomography following chimeric antigen receptor T-cell therapy in large b-cell lymphoma. Mol Imag Biol. 2021. https://doi.org/10.1007/s11307-021-01627-8.

    Article  Google Scholar 

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Correspondence to Andrea Paccagnella.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Paccagnella, A., Farolfi, A., Casadei, B. et al. 2-[18F]FDG-PET/CT for early response and brain metabolic pattern assessment after CAR-T cell therapy in a diffuse large B cell lymphoma patient with ICANS. Eur J Nucl Med Mol Imaging 49, 1090–1091 (2022). https://doi.org/10.1007/s00259-021-05562-2

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