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A prospective observational study on the long-term results of 90Yttrium citrate radiosynoviorthesis of synovitis in osteoarthritis of the knee joint

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European Journal of Nuclear Medicine and Molecular Imaging Aims and scope Submit manuscript

Abstract

Objectives

Radiosynoviorthesis (RSO) is used for the treatment of inflammatory joint diseases. However, there are no long-term results published comparing it to conservative therapy. Therefore, the aim of this prospective observational study was to evaluate response rates after radionuclide therapy in patients suffering from knee osteoarthritis over a time period of 10 years.

Methods

Radionuclide therapy with intra-articular administration of colloidal 90Yttrium citrate was performed in osteoarthritic patients [Kellgren–Lawrence grades I/II (n = 69) and Kellgren–Lawrence grade III (n = 72)].

Results

In patients with early-stage disease, an excellent/good response with respect to pain, joint mobility, and function was observed in 82.5% for 1 year and in 73.7% for 8 years after therapy. Responses declined to 50% at 10 years post treatment. In grade III patients, an excellent/good response was observed in 45.9%; a decline to 41.2% was observed in the first 8 years. In this group, the number of patients available for follow-up after 9 and 10 years dropped significantly from 51 patients after 8 years to only 30 patients after 9 years, and to nine patients after 10 years. As a result, these response rates were not appraisable.

Conclusion

Long-term results of radiosynoviorthesis in knee osteoarthritis are excellent/good in many patients. The response rate depends on Kellgren–Lawrence stages, and early-stage radionuclide therapy for osteoarthritis is suggested.

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Acknowledgments

The authors would like to thank Prof. Dr. Rigobert Klett (Gießen/Germany) for statistical evaluation of the response data. We would like to thank Dr. Gopinath Gnanasegaran (London/UK) for English editing.

Funding

No specific grant was received from any funding agency in the public, commercial, or not-for-profit sector.

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Authors and Affiliations

  1. Department of Rheumatology, Polyclinic of the Hospitaller Brothers of St. John of God Budapest, Semmelweis University, Budapest, Hungary

    Margit Szentesi, Zoltán Nagy, Pal Géher & István Papp

  2. Nuclear Medicine Spitalerhof, Hamburg, Germany

    Willm Uwe Kampen

Authors
  1. Margit Szentesi
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  2. Zoltán Nagy
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  3. Pal Géher
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  4. István Papp
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  5. Willm Uwe Kampen
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Corresponding author

Correspondence to Willm Uwe Kampen.

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Disclosure of potential conflicts of interest

The authors have nothing to disclose.

Ethical approval

This prospective study was approved the Research Ethics Committee of the Polyclinic of the Hospitaller Brothers of St. John in God, Semmelweis University Budapest on Sept. 2nd, 2008, confirmed on March 27th, 2019 (Dr. R. Bernadette, Dr. G. László). All procedures performed in the study involving human participants were in accordance with the ethical standards of the institutional and national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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Szentesi, M., Nagy, Z., Géher, P. et al. A prospective observational study on the long-term results of 90Yttrium citrate radiosynoviorthesis of synovitis in osteoarthritis of the knee joint. Eur J Nucl Med Mol Imaging 46, 1633–1641 (2019). https://doi.org/10.1007/s00259-019-04350-3

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  • DOI: https://doi.org/10.1007/s00259-019-04350-3

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