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Venous thrombosis: a mimic of musculoskeletal injury on MR imaging

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Abstract

Clinical signs and symptoms of venous thrombosis and musculoskeletal pathologies frequently overlap. Sometimes, patients with venous thrombosis undergo MR examinations under an equivocal suspicion of muscle, tendon or articular injury. A low pretest clinical suspicion and lack of familiarity with the conventional MR imaging signs of venous thrombosis may result in failure to diagnose venous thrombosis, delaying treatment and raising morbimortality. In MR imaging, thrombosis presents as venous ectasia with intraluminal heterogeneous content. Small vein thrombosis is often identified as having a branching aspect. Perivenous edema and inflammatory soft tissue changes may be the most prominent findings. The purpose of this paper is to illustrate MR findings of venous thrombosis in patients who underwent MR examinations due to suspected musculoskeletal pathologies. Cases of venous thrombosis in different sites of the body diagnosed through MR are presented.

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References

  1. Delgado GJ, Chung CB, Lektrakul N, Azocar P, Botte MJ, Coria D, et al. Tennis leg: clinical US study of 141 patients and anatomic investigation of four cadavers with MR imaging and US. Radiology. 2002;224(1):112–9.

    PubMed  Google Scholar 

  2. Hull R, Hirsh J, Sackett DL, Taylor DW, Carter C, Turpie AG, et al. Clinical validity of a negative venogram in patients with clinically suspected venous thrombosis. Circulation. 1981;64(3):622–5.

    CAS  PubMed  Google Scholar 

  3. Parellada AJ, Morrison WB, Reiter SB, Carrino JA, Glickman PL, Kloss LA, et al. Unsuspected lower extremity deep venous thrombosis simulating musculoskeletal pathology. Skeletal Radiol. 2006;35(9):659–64.

    PubMed  Google Scholar 

  4. Nielsen JD. The incidence of pulmonary embolism during deep vein thrombosis. Phlebology. 2013;28(Suppl 1):29–33.

    PubMed  Google Scholar 

  5. Silverstein MD, Heit JA, Mohr DN, Petterson TM, O’Fallon WM, Melton LJ. Trends in the incidence of deep vein thrombosis and pulmonary embolism: a 25-year population-based study. Arch Intern Med. 1998;158(6):585–93.

    CAS  PubMed  Google Scholar 

  6. Anderson FA, Wheeler HB, Goldberg RJ, Hosmer DW, Patwardhan NA, Jovanovic B, et al. A population-based perspective of the hospital incidence and case-fatality rates of deep vein thrombosis and pulmonary embolism. The Worcester DVT Study. Arch Intern Med. 1991;151(5):933–8.

    PubMed  Google Scholar 

  7. Galanaud JP, Bosson JL, Genty C, Presles E, Cucherat M, Sevestre MA, et al. Superficial vein thrombosis and recurrent venous thromboembolism: a pooled analysis of two observational studies. J Thromb Haemost. 2012;10(6):1004–11.

    CAS  PubMed  Google Scholar 

  8. Galanaud JP, Sevestre MA, Pernod G, Kahn SR, Genty C, Terrisse H, et al. Long-term risk of venous thromboembolism recurrence after isolated superficial vein thrombosis. J Thromb Haemost. 2017;15(6):1123–31.

    PubMed  Google Scholar 

  9. Spritzer CE, Sostman HD, Wilkes DC, Coleman RE. Deep venous thrombosis: experience with gradient-echo MR imaging in 66 patients. Radiology. 1990;177(1):235–41.

    CAS  PubMed  Google Scholar 

  10. Wang MS, Haynor DR, Wilson GJ, Maki JH. Intravascular hematocrit layering in equilibrium phase contrast-enhanced MR angiography of the peripheral vasculature. J Magn Reson Imaging. 2006;24(6):1393–400.

    PubMed  Google Scholar 

  11. Ambrose N, Pierce IT, Gatehouse PD, Haskard DO, Firmin DN. Magnetic resonance imaging of vein wall thickness in patients with Behçet’s syndrome. Clin Exp Rheumatol. 2014;32(4 Suppl 84):S99-102.

    PubMed  Google Scholar 

  12. Evans AJ, Sostman HD, Witty LA, Paulson EK, Spritzer CE, Hertzberg BS, et al. Detection of deep venous thrombosis: prospective comparison of MR imaging and sonography. J Magn Reson Imaging. 1996;6(1):44–51.

    CAS  PubMed  Google Scholar 

  13. Fraser DG, Moody AR, Davidson IR, Martel AL, Morgan PS. Deep venous thrombosis: diagnosis by using venous enhanced subtracted peak arterial MR venography versus conventional venography. Radiology. 2003;226(3):812–20.

    PubMed  Google Scholar 

  14. Jensen AD, Borris LC, Christiansen TM, Lundorf E. Accuracy of magnetic resonance imaging in the diagnosis of deep vein thrombosis in asymptomatic patients with injuries of the lower extremity. Pilot Study Thromb Res. 2001;101(6):423–6.

    CAS  PubMed  Google Scholar 

  15. Duncan DP, Taddonio M, Chang EY, Huang BK. Characterization of intramuscular calf vein thrombosis on routine knee MRI. Skeletal Radiol. 2019;48(10):1573–80.

    PubMed  Google Scholar 

  16. Schulman S, Granqvist S, Juhlin-Dannfelt A, Lockner D. Long-term sequelae of calf vein thrombosis treated with heparin or low-dose streptokinase. Acta Med Scand. 1986;219(4):349–57.

    CAS  PubMed  Google Scholar 

  17. Liu PT, Ilaslan H. Unicompartmental muscle edema: an early sign of deep venous thrombosis. Skeletal Radiol. 2003;32(1):41–5.

    PubMed  Google Scholar 

  18. Labropoulos N, Webb KM, Kang SS, Mansour MA, Filliung DR, Size GP, et al. Patterns and distribution of isolated calf deep vein thrombosis. J Vasc Surg. 1999;30(5):787–91.

    CAS  PubMed  Google Scholar 

  19. Turpie AG, Esmon C. Venous and arterial thrombosis–pathogenesis and the rationale for anticoagulation. Thromb Haemost. 2011;105(4):586–96.

    CAS  PubMed  Google Scholar 

  20. Joffe HV, Goldhaber SZ. Upper-extremity deep vein thrombosis. Circulation. 2002;106(14):1874–80.

    PubMed  Google Scholar 

  21. Kim HY, Cho EB, Youn SH, Park EJ, Kwon IH, Kim KH, et al. Two cases of thrombosis of the palmar digital vein. Ann Dermatol. 2012;24(3):351–4.

    PubMed  PubMed Central  Google Scholar 

  22. Decousus H, Quéré I, Presles E, Becker F, Barrellier MT, Chanut M, et al. Superficial venous thrombosis and venous thromboembolism: a large, prospective epidemiologic study. Ann Intern Med. 2010;152(4):218–24.

    PubMed  Google Scholar 

  23. Miranda FC, Carneiro RD, Longo CH, Fernandes TD, Rosemberg LA, de GusmãoFunari MB. Plantar thrombophlebitis: magnetic resonance imaging findings. Rev Bras Ortop. 2012;47(6):765–9.

    PubMed  Google Scholar 

  24. Vansevenant M, Vanhoenacker FM. Plantar vein thrombosis: an unusual cause of plantar pain. J Belg Soc Radiol. 2015;99(2):98–101.

    CAS  PubMed  PubMed Central  Google Scholar 

  25. Long A, Bura-Riviere A, Sapoval M. Plantar venous thrombosis and anticardiolipin antibody syndrome. Case report. J Mal Vasc. 2004;29(1):39–40.

    CAS  PubMed  Google Scholar 

  26. Barros MV, Labropoulos N. Plantar vein thrombosis–evaluation by ultrasound and clinical outcome. Angiology. 2010;61(1):82–5.

    PubMed  Google Scholar 

  27. Czihal M, Röling J, Rademacher A, Schröttle A, Kuhlencordt P, Hoffmann U. Clinical characteristics and course of plantar vein thrombosis: a series of 22 cases. Phlebology. 2015;30(10):714–8.

    CAS  PubMed  Google Scholar 

  28. Karam L, Tabet G, Nakad J, Gerard JL. Spontaneous plantar vein thrombosis: state of the art. Phlebology. 2013;28(8):432–7.

    CAS  PubMed  Google Scholar 

  29. Geiger C, Rademacher A, Chappell D, Sadeghi-Azandaryani M, Heyn J. Plantar vein thrombosis due to busy night duty on intensive care unit. Clin Appl Thromb Hemost. 2011;17(2):232–4.

    PubMed  Google Scholar 

  30. Bernathova M, Bein E, Bendix N, Bodner G. Sonographic diagnosis of plantar vein thrombosis: report of 3 cases. J Ultrasound Med. 2005;24(1):101–3.

    PubMed  Google Scholar 

  31. Barros M, Nascimento I, Barros T, Labropoulos N. Plantar vein thrombosis and pulmonary embolism. Phlebology. 2015;30(1):66–9.

    PubMed  Google Scholar 

  32. Natarajan A, Amarvathi R, Philip B, Rozario A. Ruptured Baker’s cyst simulating deep venous thrombosis. Trop Doct. 2003;33(2):106–7.

    PubMed  Google Scholar 

  33. Choi KW, Yoon KB, Yoon DM, Kim DH. Popliteal fossa pain in 24 year-old female. Korean J Pain. 2012;25(4):275–7.

    PubMed  PubMed Central  Google Scholar 

  34. Shulman RM, Buchan C, Bleakney RR, White LM. Low prevalence of unexpected popliteal DVT detected on routine MRI assessment of the knee. Clin Imaging. 2016;40(1):79–85.

    PubMed  Google Scholar 

  35. Schmitt HE, Mihatsch MJ. Thrombosis of the popliteal vein. Cardiovasc Intervent Radiol. 1992;15(4):234–9.

    CAS  PubMed  Google Scholar 

  36. Chaudhuri R, Salari R. Baker’s cyst simulating deep vein thrombosis. Clin Radiol. 1990;41(6):400–4.

    CAS  PubMed  Google Scholar 

  37. Ozgocmen S, Kocakoc E, Kiris A, Ardicoglu O. Pseudothrombophlebitis in a patient with Behçet’s syndrome: Doppler ultrasound and magnetic resonance imaging findings. Clin Rheumatol. 2002;21(1):60–2.

    CAS  PubMed  Google Scholar 

  38. Miller TT, Staron RB, Koenigsberg T, Levin TL, Feldman F. MR imaging of Baker cysts: association with internal derangement, effusion, and degenerative arthropathy. Radiology. 1996;201(1):247–50.

    CAS  PubMed  Google Scholar 

  39. Herman AM, Marzo JM. Popliteal cysts: a current review. Orthopedics. 2014;37(8):e678-684.

    PubMed  Google Scholar 

  40. Lazarus ML, Ray CE, Maniquis CG. MRI findings of concurrent acute DVT and dissecting popliteal cyst. Magn Reson Imaging. 1994;12(1):155–8.

    CAS  PubMed  Google Scholar 

  41. Campbell JT. Posterior calf injury. Foot Ankle Clin. 2009;14(4):761–71.

    PubMed  Google Scholar 

  42. Kret MR, Liem TK, Mitchell EL, Landry GJ, Moneta GL. Isolated calf muscular vein thrombosis is associated with pulmonary embolism and a high incidence of additional ipsilateral and contralateral deep venous thrombosis. J Vasc Surg Venous Lymphat Disord. 2013;1(1):33–8.

    PubMed  Google Scholar 

  43. Spritzer CE, Arata MA, Freed KS. Isolated pelvic deep venous thrombosis: relative frequency as detected with MR imaging. Radiology. 2001;219(2):521–5.

    CAS  PubMed  Google Scholar 

  44. Theiss JL, Fink ML, Gerber JP. Deep vein thrombosis in a young marathon athlete. J Orthop Sports Phys Ther. 2011;41(12):942–7.

    PubMed  Google Scholar 

  45. Yim ES, Friedberg RP. Case report: lower extremity deep vein thrombosis following an intense calf workout. Curr Sports Med Rep. 2012;11(6):282–6.

    PubMed  Google Scholar 

  46. Rodger MA, Avruch LI, Howley HE, Olivier A, Walker MC. Pelvic magnetic resonance venography reveals high rate of pelvic vein thrombosis after cesarean section. Am J Obstet Gynecol. 2006;194(2):436–7.

    PubMed  Google Scholar 

  47. Gary T, Steidl K, Belaj K, Hafner F, Froehlich H, Deutschmann H, et al. Unusual deep vein thrombosis sites: magnetic resonance venography in patients with negative compression ultrasound and symptomatic pulmonary embolism. Phlebology. 2014;29(1):25–9.

    CAS  PubMed  Google Scholar 

  48. Ouriel K, Green RM, Greenberg RK, Clair DG. The anatomy of deep venous thrombosis of the lower extremity. J Vasc Surg. 2000;31(5):895–900.

    CAS  PubMed  Google Scholar 

  49. Lutterbach-Penna RA, Kalume-Brigido M, Robertson BL, Jacobson JA, Girish G, Fessell DP. Deep vein thrombosis simulating hamstring injury on sonography. J Ultrasound Med. 2012;31(4):660–2.

    PubMed  Google Scholar 

  50. Lee YS, Kim J, Jeong JJ. Deep vein thrombosis in the thigh: MR imaging in two cases with atypical presentations. Skeletal Radiol. 2022;51(7):1511–6.

    PubMed  Google Scholar 

  51. Stamatakis JD, Kakkar VV, Sagar S, Lawrence D, Nairn D, Bentley PG. Femoral vein thrombosis and total hip replacement. Br Med J. 1977;2(6081):223–5.

    CAS  PubMed  PubMed Central  Google Scholar 

  52. Şener S, Demirhan N. An uncommon cause of hip pain: isolated gluteal deep venous thrombosis associated with prolonged seated immobility. Turk J Thorac Cardiovasc Surg. 2013;21(2):497–9.

    Google Scholar 

  53. Papastergiou SG, Koukoulias NE, Tsitouridis I, Natsis C, Parisis CA. Circumflex femoral vein thrombosis misinterpreted as acute hamstring strain. Br J Sports Med. 2007;41(7):460–1.

    PubMed  PubMed Central  Google Scholar 

  54. Brown SC, Gewillig M. Ever heard of the obturator vein? Catheter Cardiovasc Interv. 2010;75(3):416–9.

    PubMed  Google Scholar 

  55. Ploton G, Pistorius MA, Raimbeau A, Denis Le Seve J, Bergère G, Ngohou C, et al. A STROBE cohort study of 755 deep and superficial upper-extremity vein thrombosis. Medicine (Baltimore). 2020;99(6):e18996.

    PubMed  Google Scholar 

  56. Feinberg J, Nielsen EE, Jakobsen JC. Thrombolysis for acute upper extremity deep vein thrombosis. Cochrane Database Syst Rev. 2017;12:CD012175.

    PubMed  Google Scholar 

  57. Kucher N. Clinical practice. Deep-vein thrombosis of the upper extremities. N Engl J Med. 2011;364(9):861–9.

    CAS  PubMed  Google Scholar 

  58. Louis J. Axillary vein thrombosis mimicking muscular strain. J Accid Emerg Med. 1999;16(3):233–4.

    CAS  PubMed  PubMed Central  Google Scholar 

  59. Alla VM, Natarajan N, Kaushik M, Warrier R, Nair CK. Paget-schroetter syndrome: review of pathogenesis and treatment of effort thrombosis. West J Emerg Med. 2010;11(4):358–62.

    PubMed  PubMed Central  Google Scholar 

  60. van Rossum M, van der Lei B, van Wingerden JJ. Thrombosis of the palmar digital veins: a report of 6 cases and a review of the literature. Ann Plast Surg. 2005;55(6):629–32.

    PubMed  Google Scholar 

  61. Hofer T. Palmar digital vein thromboses: their different expressions. Dermatology. 2002;204(3):240–3.

    CAS  PubMed  Google Scholar 

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Correspondence to Renata Vidal Leão.

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Leão, R.V., Bernal, E.C.B.A., Rodrigues, M.B. et al. Venous thrombosis: a mimic of musculoskeletal injury on MR imaging. Skeletal Radiol 52, 1263–1276 (2023). https://doi.org/10.1007/s00256-022-04258-4

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