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Surface-type chondromyxoid fibroma in an elderly patient: a case report and literature review

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Abstract

Chondromyxoid fibroma (CMF) is a rare benign bone neoplasm that typically occurs in young adults. Juxtacortical or surface-type CMF are rarer still and we present the case of a surface-type CMF in a 78-year-old woman, with only one other case described in a patient of a similar age previously. This patient was an otherwise healthy woman who presented for evaluation of a palpable lump in the anterior proximal tibia. Initial radiographs obtained demonstrated a focal soft tissue fullness immediately anterior to the anterior cortex of the proximal tibia, which contained faint chondroid-like matrix internally. There was associated scalloping of the anterior tibial cortex. MRI confirmed the presence of a juxtacortical, enhancing lesion. Subsequent excisional biopsy was performed and histopathology demonstrated features, which was consistent with surface-type CMF. At a 6-month follow-up the patient remained free of recurrence. In a patient of this age, paraosteal chondrosarcoma should be excluded. Surface-type CMF, although rare, has been described in older patients and while it is unlikely to feature in a list of differential considerations on initial imaging, awareness of the entity is important.

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References

  1. Unni K. Dahlin's bone tumors general aspects and data on 11,087 cases. 6th ed. Philadelphia: Lippincott Williams & Wilkins; 2010.

    Google Scholar 

  2. Baker AC, Rezeanu L, O'Laughlin S, Unni K, Klein MJ, Siegal GP. Juxtacortical chondromyxoid fibroma of bone: a unique variant: a case study of 20 patients. Am J Surg Pathol. 2007;31(11):1662–8.

    Article  PubMed  Google Scholar 

  3. Soni R, Kapoor C, Shah M, Turakhiya J, Golwala P. Chondromyxoid fibroma: a rare case report and review of literature. Cureus. 2016;8(9):e803.

    PubMed  PubMed Central  Google Scholar 

  4. Jaffe HL, Lichtenstein L. Chondromyxoid fibroma of bone; a distinctive benign tumor likely to be mistaken especially for chondrosarcoma. Arch Pathol (Chic). 1948;45(4):541–51.

    CAS  Google Scholar 

  5. Ralph LL. Chondromyxoid fibroma of bone. J Bone Joint Surg Br. 1962;44-B:7–24.

    Article  CAS  PubMed  Google Scholar 

  6. Schajowicz F. Chondromyxoid fibroma: report of three cases with predominant cortical involvement. Radiology. 1987;164(3):783–6.

    Article  CAS  PubMed  Google Scholar 

  7. Andrew T, Kenwright J, Woods C. Periosteal chondromyxoid fibroma of the tibia: a case report. Acta Orthop Scand. 1982;53(3):467–70.

    Article  CAS  PubMed  Google Scholar 

  8. Bialik V, Kedar A, Ben-Arie Y, Kleinhaus U, Fishman J. Case report 315. Diagnosis: parosteal (periosteal, juxtacortical) chondromyxoid fibroma of the upper end of the femur. Skelet Radiol. 1985;13(4):323–6.

    Article  CAS  Google Scholar 

  9. Kenan S, Abdelwahab IF, Klein MJ, Lewis MM. Case report 837: Juxtacortical (periosteal) chondromyxoid fibroma of the proximal tibia. Skelet Radiol. 1994;23(3):237–9.

    CAS  Google Scholar 

  10. Park HR, Lee IS, Lee CJ, Park YK. Chondromyxoid fibroma of the femur: a case report with intra-cortical location. J Korean Med Sci. 1995;10(1):51–6.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Marin C, Gallego C, Manjon P, Martinez-Tello FJ. Juxtacortical chondromyxoid fibroma: imaging findings in three cases and a review of the literature. Skelet Radiol. 1997;26(11):642–9.

    Article  CAS  Google Scholar 

  12. Park SH, Kong KY, Chung HW, Kim CJ, Lee SH, Kang HS. Juxtacortical chondromyxoid fibroma arising in an apophysis. Skelet Radiol. 2000;29(8):466–9.

    Article  CAS  Google Scholar 

  13. Fujiwara S, Nakamura I, Goto T, Motoi T, Yokokura S, Nakamura K. Intracortical chondromyxoid fibroma of humerus. Skelet Radiol. 2003;32(3):156–60.

    Article  Google Scholar 

  14. Takenaga RK, Frassica FJ, McCarthy EF. Subperiosteal chondromyxoid fibroma: a report of two cases. Iowa Orthop J. 2007;27:104–7.

    PubMed  PubMed Central  Google Scholar 

  15. Jhala D, Coventry S, Rao P, Yen F, Siegal GP. Juvenile juxtacortical chondromyxoid fibroma of bone: a case report. Hum Pathol. 2008;39(6):960–5.

    Article  PubMed  Google Scholar 

  16. Han JS, Shim E, Kim BH, Choi JW. An intracortical chondromyxoid fibroma in the diaphysis of the metatarsal. Skelet Radiol. 2017;46(12):1757–62.

    Article  Google Scholar 

  17. Fernandez-Hernandez O, Ramos-Pascua L, Izquierdo-Garcia F. Intracortical chondromyxoid fibroma of the tibia. Musculoskelet Surg. 2013;97(2):177–81.

    Article  PubMed  Google Scholar 

  18. Abdelwahab IF, Klein MJ. Surface chondromyxoid fibroma of the distal ulna: unusual tumor, site, and age. Skelet. Radiol. 2014;43(2):243–6.

    Article  Google Scholar 

  19. Wu CT, Inwards CY, O'Laughlin S, Rock MG, Beabout JW, Unni KK. Chondromyxoid fibroma of bone: a clinicopathologic review of 278 cases. Hum Pathol. 1998;29(5):438–46.

    Article  CAS  PubMed  Google Scholar 

  20. Levine SM, Lambiase RE, Petchprapa CN. Cortical lesions of the tibia: characteristic appearances at conventional radiography. RadioGraphics. 2003;23(1):157–77.

    Article  PubMed  Google Scholar 

  21. Yamaguchi T, Dorfman HD. Radiographic and histologic patterns of calcification in chondromyxoid fibroma. Skelet Radiol. 1998;27(10):559–64.

    Article  CAS  Google Scholar 

  22. Klein JS, Braff S. Imaging evaluation of the solitary pulmonary nodule. Clin Chest Med. 2008;29(1):15–38 v.

    Article  PubMed  Google Scholar 

  23. Seeger LL, Yao L, Eckardt JJ. Surface lesions of bone. Radiology. 1998;206(1):17–33.

    Article  CAS  PubMed  Google Scholar 

  24. Gholamrezanezhad A, Basques K, Kosmas C. Peering beneath the surface: juxtacortical tumors of bone (part II). Clin Imaging. 2018;50:113–22.

    Article  PubMed  Google Scholar 

  25. Gholamrezanezhad A, Basques K, Kosmas C. Peering beneath the surface: juxtacortical tumors of bone (part I). Clin Imaging. 2018;51:1–11.

    Article  PubMed  Google Scholar 

  26. Schlesinger AE, Hernandez RJ. Intracapsular osteoid osteoma of the proximal femur: findings on plain film and CT. AJR Am J Roentgenol. 1990;154(6):1241–4.

    Article  CAS  PubMed  Google Scholar 

  27. Chaabane S, Bouaziz MC, Drissi C, Abid L, Ladeb MF. Periosteal chondrosarcoma. AJR Am J Roentgenol. 2009;192(1):W1–6.

    Article  PubMed  Google Scholar 

  28. Abdelwahab IF, Kenan S, Hermann G, Klein MJ, Lewis MM. Periosteal ganglia: CT and MR imaging features. Radiology. 1993;188(1):245–8.

    Article  CAS  PubMed  Google Scholar 

  29. Zillmer DA, Dorfman HD. Chondromyxoid fibroma of bone: thirty-six cases with clinicopathologic correlation. Hum Pathol. 1989;20(10):952–64.

    Article  CAS  PubMed  Google Scholar 

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Correspondence to Kate Anne Harrington.

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Harrington, K.A., Hoda, S. & La Rocca Vieira, R. Surface-type chondromyxoid fibroma in an elderly patient: a case report and literature review. Skeletal Radiol 48, 823–830 (2019). https://doi.org/10.1007/s00256-018-3120-4

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  • DOI: https://doi.org/10.1007/s00256-018-3120-4

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