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The research of aptamer biosensor technologies for detection of microorganism

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Abstract

The activities and transmissions of microorganisms are closely related to human, and all kinds of diseases caused by pathogenic microorganisms have attracted attention in the world and brought many challenges to human health and public health. The traditional microbial detection technologies have characteristics of longer detection cycle and complicated processes, therefore, which can no longer meet the detection requirements in the field of public health. At present, it is the focus to develop and design a novel, rapid, and simple microbial detection method in the field of public health. Herein, this article summarized the development of aptamer biosensor technologies for detection of microorganism in the aspect of bacteria, viruses, and toxins in detail, including optical aptamer sensors such as fluorometry and colorimetry, electrochemical aptamer sensors, and other technologies combined with aptamer.

Key points

• Aptamer biosensor is a good platform for microbial detection.

• Aptamer biosensors include optical sensors and electrochemical sensors.

• Aptamer sensors have been widely used in the detection of bacteria, viruses, and other microorganisms.

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Funding

This work was supported by the National Science Foundation of China under Grant [21676305] and Food and Drug Safety Science and Technology projects of Hunan Food and Drug Administration [R201704].

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Authors and Affiliations

  1. Xiang Ya School of Public Health, Central South University, Changsha, 410078, Hunan, China

    Jiecan Yi, Pian Wu, Yayuan He, Cuimei Chen, Yafei He & Ping Ding

  2. School of Public Health, Changsha Medical University, Changsha, 410219, Hunan, China

    Jiecan Yi

  3. Hunan Institute of Food Quality Supervision Inspection and Research, Changsha, 410000, Hunan, China

    Wen Xiao

  4. School of Life and Environmental Sciences, Guilin University of Electronic Technology, Guilin, 541014, Guangxi, China

    Guiyin Li

  5. College of Chemistry and Chemical Engineering, Central South University, Changsha, 410078, Hunan, China

    Tianhan Kai

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  1. Jiecan Yi
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  2. Wen Xiao
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  3. Guiyin Li
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  4. Pian Wu
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  5. Yayuan He
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  9. Tianhan Kai
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DP conceived the ideas and concepts of the manuscript. All authors wrote, reviewed, and approved the manuscript.

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Yi, J., Xiao, W., Li, G. et al. The research of aptamer biosensor technologies for detection of microorganism. Appl Microbiol Biotechnol 104, 9877–9890 (2020). https://doi.org/10.1007/s00253-020-10940-1

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