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Reversed cortico-medullary differentiation in the fetal and neonatal kidneys: an indicator of poor prognosis?

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Abstract

Background

Bilateral reversed cortico-medullary differentiation is rarely observed on fetal or neonatal renal ultrasound and is therefore a diagnostic challenge.

Objective

Our purpose was to widen the differential diagnoses of fetal and neonatal nephropathies introducing reversed cortico-medullary differentiation as a clue either on obstetric US or during follow-up of hyperechoic kidneys in order to improve the management of such rare clinical situations.

Materials and methods

We retrospectively reviewed the US images of 11 patients showing bilateral reversed cortico-medullary differentiation on prenatal examination or in which this pattern developed postnatally in the follow-up of fetal hyperechoic kidneys. For each patient, a precise diagnosis was established either on clinical assessment or, when available, on histological or genetic findings.

Results

Six fetuses displayed bilateral reversed cortico-medullary differentiation on obstetric examination, and the pattern persisted throughout pregnancy. In the five other fetuses, the kidneys appeared initially homogeneously hyperechoic; this evolved into reversed cortico-medullary differentiation during the third trimester in two cases and shortly after birth in three cases. Two pregnancies were terminated because of estimated poor prognosis. In the nine surviving neonates, four died of renal failure in the post-natal period. The clinical evolution was more favorable in the remaining five newborns.

Conclusions

Six different diagnoses were established in patients presenting with a reversed cortico-medullary differentiation renal pattern. This finding was associated with poor outcome in six cases. An acute prenatal diagnosis of reversed cortico-medullary differentiation improves pre- and postnatal work-up and guides counseling and genetic testing.

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Data availability

The datasets analyzed during the current study are available from the corresponding author on reasonable request.

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Author information

Authors and Affiliations

  1. Department of Radiology and Fetal Medicine, Iris Hospitals South, 63 Rue J. Paquot, 1050, Brussels, Belgium

    Marie Cassart

  2. Department of Radiology, Armand-Trousseau Hospital, APHP, Sorbonne University, Paris, France

    Catherine Garel

  3. Pediatric Nephrology Unit, Armand-Trousseau Hospital, APHP, Sorbonne University, Paris, France

    Tim Ulinski

  4. Department of Medical Imaging, Marie Curie Civil Hospital, Charleroi, Belgium

    E. Freddy Avni

Authors
  1. Marie Cassart
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  2. Catherine Garel
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  3. Tim Ulinski
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  4. E. Freddy Avni
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Contributions

Concept for the article: E.F.A. Interpretation of the images: MC, CG, EF.A.;  Literature search, collecting data, analysis and writing: M.C., C.G., E.F.A.; Draft preparation and revision: M.C., C.G., T.U., E.F.A.

Corresponding author

Correspondence to Marie Cassart.

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Ethical approval

Institutional Review Board approval was not required because it is an observational study. Data were collected according the institutions’ ethical requirements.

Informed consent

Written informed consent was not required for this study because it corresponds to a retrospective observational study; images were anonymized for review.

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Cassart, M., Garel, C., Ulinski, T. et al. Reversed cortico-medullary differentiation in the fetal and neonatal kidneys: an indicator of poor prognosis?. Pediatr Radiol 54, 285–292 (2024). https://doi.org/10.1007/s00247-023-05833-0

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  • DOI: https://doi.org/10.1007/s00247-023-05833-0

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