Skip to main content
Log in

Percutaneous CT-guided epidural fibrin sealant injection for refractory pediatric post-dural puncture headache

  • Case Report
  • Published:
Pediatric Radiology Aims and scope Submit manuscript

Abstract

Post-dural puncture headache is an uncommon entity in young children and adolescents. Percutaneous epidural blood patching has been classically used to manage refractory post-dural puncture headaches. Injectable fibrin sealant has been shown in a few adult cases to relieve symptoms where blood patching has either failed or was not appropriate. We report a 10-year-old boy who experienced rapid relief of post-dural puncture headache symptoms following percutaneous lumbar epidural fibrin sealant injection under computed tomography guidance. Percutaneous epidural fibrin sealant injection may be an acceptable treatment for post-dural puncture headaches refractory to epidural blood patching, or when an epidural blood patch is otherwise contraindicated. The pediatric interventional radiologist should be aware of this off-label use of fibrin sealant.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1

Similar content being viewed by others

References

  1. Frank RL (2009) Lumbar puncture and post-dural puncture headaches: implications for the emergency physician. J Emerg Med 35:149–157

    Article  Google Scholar 

  2. Janssens E, Aerssens P, Alliet P et al (2003) Post-dural puncture headaches in children. A literature review. Eur J Pediatr 162:117–121

    Article  Google Scholar 

  3. Crul BJ, Gerritse BM, van Dongen RT, Schoonderwaldt HC (1999) Epidural fibrin glue injection stops persistent postdural puncture headache. Anesthesiology 91:576–577

    Article  CAS  Google Scholar 

  4. Gladstone JP, Nelson K, Patel N, Dodlick DW (2005) Spontaneous CSF leak treated with percutaneous CT-guided fibrin glue. Neurology 64:1818–1819

    Article  Google Scholar 

  5. Wu C, Guan D, Ren M et al (2018) Aminophylline for treatment of postdural puncture headache. Neurology 90:e1523–e1529

    Article  CAS  Google Scholar 

  6. U.S. Food and Drug Administration (2013) Tisseel – Highlights of Prescribing Information. https://www.fda.gov/downloads/BloodBloodProducts/ucm072968.pdf. Accessed 8 Aug 2017

  7. Schlenker M, Ringelstein EB (1987) Epidural fibrin clot for the prevention of post-lumbar puncture headache: a new method with risks. J Neurol Neurosurg Psychiatry 50:1715

    Article  CAS  Google Scholar 

  8. De La Motte S, D'Souza G, Krane E (2016) Use of fibrin glue in a pediatric patient for resolution of spontaneous intracranial hypotensive symptoms for chronic, recalcitrant spontaneous CSF leak. Abstracts of the 41st Annual Regional Anesthesiology and Acute Pain Medicine Meeting: 2016 March 31–April 2; New Orleans, LA

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Manraj K. S. Heran.

Ethics declarations

Conflicts of interest

None

Additional information

Publisher’s note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Roberts, J.M., Peterson, V.E. & Heran, M.K.S. Percutaneous CT-guided epidural fibrin sealant injection for refractory pediatric post-dural puncture headache. Pediatr Radiol 50, 1156–1158 (2020). https://doi.org/10.1007/s00247-020-04691-4

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00247-020-04691-4

Keywords

Navigation