Abstract
Background
With the introduction of hybrid positron emission tomography/magnetic resonance imaging (PET/MRI), a new imaging option to acquire multimodality images with complementary anatomical and functional information has become available. Compared with hybrid PET/computed tomography (CT), hybrid PET/MRI is capable of providing superior anatomical detail while removing the radiation exposure associated with CT. The early adoption of hybrid PET/MRI, however, has been limited.
Objective
To provide a viable alternative to the hybrid PET/MRI hardware by validating a software-based solution for PET-MR image coregistration.
Materials and methods
A fully automated, graphics processing unit-accelerated 3-D deformable image registration technique was used to align PET (acquired as PET/CT) and MR image pairs of 17 patients (age range: 10 months–21 years, mean: 10 years) who underwent PET/CT and body MRI (chest, abdomen or pelvis), which were performed within a 28-day (mean: 10.5 days) interval. MRI data for most of these cases included single-station post-contrast axial T1-weighted images. Following registration, maximum standardized uptake value (SUVmax) values observed in coregistered PET (cPET) and the original PET were compared for 82 volumes of interest. In addition, we calculated the target registration error as a measure of the quality of image coregistration, and evaluated the algorithm’s performance in the context of interexpert variability.
Results
The coregistration execution time averaged 97±45 s. The overall relative SUVmax difference was 7% between cPET-MRI and PET/CT. The average target registration error was 10.7±6.6 mm, which compared favorably with the typical voxel size (diagonal distance) of 8.0 mm (typical resolution: 0.66 mm × 0.66 mm × 8 mm) for MRI and 6.1 mm (typical resolution: 3.65 mm × 3.65 mm × 3.27 mm) for PET. The variability in landmark identification did not show statistically significant differences between the algorithm and a typical expert.
Conclusion
We have presented a software-based solution that achieves the many benefits of hybrid PET/MRI scanners without actually needing one. The method proved to be accurate and potentially clinically useful.
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References
Chawla SC, Federman N, Zhang D et al (2010) Estimated cumulative radiation dose from PET/CT in children with malignancies: a 5-year retrospective review. Pediatr Radiol 40:681–686
Rathore N, Eissa H, Margolin JF et al (2012) Pediatric Hodgkin lymphoma: are we over-scanning our patients? Pediatr Hematol Oncol 29:415–423
Krille L, Zeeb H, Jahnen A et al (2012) Computed tomographies and cancer risk in children: a literature overview of CT practices, risk estimations and an epidemiologic cohort study proposal. Radiat Environ Biophys 51:103–111
Miglioretti D, Johnson E, Williams A et al (2013) The use of computed tomography in pediatrics and the associated radiation exposure and estimated cancer risk. JAMA Pediatr 167:700–707
Pearce MS, Salotti JA, Little MP et al (2012) Radiation exposure from CT scans in childhood and subsequent risk of leukaemia and brain tumours: a retrospective cohort study. Lancet 380:499–505
Lassman M, Treves ST, EANM/SNMMI Paediatric Dosage Harmonization Working Group (2014) Paediatric radiopharmaceutical administration: harmonization of the 2007 EANM Paediatric dosage card (version 1.5.2008) and the 2010 North American consensus guidelines. Eur J Nucl Med Mol Imaging 41:1036–1041
Gelfand MJ, Parisi MT, Treves ST et al (2011) Pediatric radiopharmaceutical administered doses: 2010 North American consensus guidelines. J Nucl Med 52:318–322
Fahey FH (2009) Dosimetry of pediatric PET/CT. J Nucl Med 50:1483–1491
Gelfand MJ, Lemen LC (2007) PET/CT and SPECT/CT dosimetry in children: the challenge to the pediatric imager. Semin Nucl Med 37:391–398
Gelfand MJ (2009) Dosimetry of FDG PET/CT and other molecular imaging applications in pediatric patients. Pediatr Radiol 39:S46–S56
Walimbe V, Shekhar R (2006) Automatic elastic image registration by interpolation of 3D rotations and translations from discrete rigid-body transformations. Med Image Anal 10:899–914
Shekhar R, Walimbe V, Shanker R (2005) Automated 3-dimensional elastic registration of whole-body PET and CT from separate or combined scanners. J Nucl Med 46:1488–1496
Studholme C, Hill DLG, Hawkes DJ (1999) An overlap invariant entropy measure of 3D medical image alignment. Pattern Recognit 32:71–86
Mattes D, Haynor DR, Vesselle H et al (2003) PET-CT image registration in the chest using free-form deformations. IEEE Trans Med Imaging 22:120–128
Fedorov A, Beichel R, Kalpathy-Cramer J et al (2012) 3D Slicer as an image computing platform for the quantitative image network. Magn Reson Imaging 30:1323–1341
Lei P, Dandekar O, Widlus D et al (2010) Incorporation of preprocedural PET into CT-guided radiofrequency ablation of hepatic metastases: a nonrigid image registration validation study. J Digit Imaging 23:780–792
Li W, Robertson M, Plishker W et al (2014) Integration of high-speed single- and multi-modality deformable image registration with clinical PACS. Pediatr Radiol 44:S93–S94
de Langen AJ, Vincent A, Velasquez LM et al (2012) Repeatability of 18F-FDG uptake measurements in tumors: a metaanalysis. J Nucl Med 53:701–708
Heusch P, Buchbender C, Beiderwellen K et al (2013) Standardized uptake values for [18F] FDG in normal organ tissues: comparison of whole-body PET/CT and PET/MRI. Eur J Radiol 82:870–876
Kershah S, Partovi S, Traughber BJ et al (2013) Comparison of standardized uptake values in normal structures between PET/CT and PET/MRI in an oncology patient population. Mol Imaging Biol 15:776–785
Pace L, Nicolai E, Luongo A et al (2014) Comparison of whole-body PET/CT and PET/MRI in breast cancer patients: lesion detection and quantitation of 18F-deoxyglucose uptake in lesions and in normal organ tissues. Eur J Radiol 83:289–296
Wiesmuller M, Quick H, Navalpakkam B et al (2013) Comparison of lesion detection and quantitation of tracer uptake between PET from a simultaneously acquiring whole-body PET/MR hybrid scanner and PET from PET/CT. Eur J Nucl Med Mol Imaging 40:12–21
Drzezga A, Souvatzoglou M, Eiber M et al (2012) First clinical experience with integrated whole-body PET/MR: Comparison to PET/CT in patients with oncologic diagnoses. J Nucl Med 53:845–855
Chin BB, Green ED, Turkington TG et al (2009) Increasing uptake time in FDG-PET: Standardized uptake values in normal tissues at 1 versus 3 h. Mol Imaging Biol 11:118–122
Rakheja R, DeMello L, Chandarana H et al (2013) Comparison of the accuracy of PET/CT and PET/MRI spatial registration of multiple metastatic lesions. AJR Am J Roentgenol 201:1120–1123
Schmidt H, Brendle C, Schraml C et al (2013) Correlation of simultaneously acquired diffusion-weighted imaging and 2-deoxy-[18F] fluoro-2-D-glucose positron emission tomography of pulmonary lesions in a dedicated whole-body magnetic resonance/positron emission tomography system. Invest Radiol 48:247–255
Brendle CB, Schmidt H, Fleischer S et al (2013) Simultaneously acquired MR/PET images compared with sequential MR/PET and PET/CT: alignment quality. Radiology 268:190–199
Fahey FH, Palmer MR, Strauss KJ et al (2007) Dosimetry and adequacy of CT-based attenuation correction for pediatric PET: phantom study. Radiology 243:96–104
Acknowledgments
This work was supported by the National Institutes of Health grant R42CA137886.
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All procedures performed in the studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
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Robertson, M.S., Liu, X., Plishker, W. et al. Software-based PET-MR image coregistration: combined PET-MRI for the rest of us!. Pediatr Radiol 46, 1552–1561 (2016). https://doi.org/10.1007/s00247-016-3641-8
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DOI: https://doi.org/10.1007/s00247-016-3641-8