Abstract
Midaortic syndrome (MAS) presents challenges in diagnosis due to the absence of well-defined diagnostic criteria in pediatric patients. This retrospective study aimed to aid in the diagnosis of MAS by employing computed tomography (CT) to measure the z-score of the aorta as well as to identify and understand its clinical features. CT images, echocardiography findings, and medical records of 17 patients diagnosed with MAS between 1997 and 2023 were reviewed, and z-scores were calculated. Aortic size on follow-up CT, blood pressure, and left ventricular function and hypertrophy at the last follow-up were analyzed, and possible prognostic factors were examined. Except for one patient, all individuals exhibited a z-score below − 2 at the level corresponding to stenosis. Left ventricular dysfunction occurred more frequently in patients aged < 5 years (p = 0.024). Patients with idiopathic MAS showed a better prognosis in terms of blood pressure and follow-up aortic size (p = 0.051 and 0.048, respectively). CT-measured aortic z-scores may be useful for the diagnosis and follow-up of MAS.
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All authors contributed to the study conception and design. GBK suggested an idea regarding the difficulties of diagnosing midaortic syndrome due to lack of established references for aortic size in the CT, and proposed of conducting research. Data collection and analysis were performed by SMB. Computed tomography image and Doppler kidney sonography was reviewed by YSL and Echocardiography was reviewed by MKS and EJB. The first draft of the manuscript was written by SMB and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.
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Baek, S.M., Lee, Y.S., Song, M.K. et al. Computed Tomography Measurement of the Aorta in Midaortic Syndrome in Children and Adolescents and Their Clinical Manifestations and Outcomes. Pediatr Cardiol (2024). https://doi.org/10.1007/s00246-023-03399-0
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DOI: https://doi.org/10.1007/s00246-023-03399-0