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Congenital Coronary Artery Anomalies and Sudden Cardiac Death

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Abstract

Coronary artery anomalies (CAAs) are a heterogeneous group of rare congenital diseases whose features and pathophysiological mechanisms are extremely variable, ranging from silent anomalies to sudden cardiac death (SCD) in the most severe cases. Although rare, congenital CAAs confer a high risk of myocardial ischemia and SCD, especially in young, previously “healthy” athletes during or immediately after vigorous exertion. Although some high-risk features that may lead to SCD have been identified, specific pathophysiological mechanisms related to SCD still remain poorly understood. When a CAA is incidentally diagnosed, optimal SCD risk stratification remains challenging, particularly in cases of anomalous aortic origin of a coronary artery arising from the opposite aortic sinus of Valsalva (ACAOS). In recent times, invasive imaging with intravascular ultrasound has gained a role in further identifying high-risk anatomic features; it has been integrated with traditional, non-invasive anatomic imaging evaluations, typically high-quality echocardiography, and cardiac magnetic resonance. Multidisciplinary programs and specific SCD risk scores should be developed in an endeavor to choose the right therapeutic approach, either clinical or interventional/surgical. Intravascular ultrasound is an extremely useful tool to evaluate vessel stenosis, even if prospective studies are still required to further validate this diagnostic strategy. In the present review, we aimed to analyze the pathophysiology and the clinical impact of ACAOS. We also summarized the predominant mechanisms for interference with normal coronary artery function, which might contribute to the onset of life-threatening arrhythmias and SCD.

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References

  1. Emery MS, Kovacs RJ (2018) Sudden cardiac death in athletes. JACC Hear Fail 6:30–40. https://doi.org/10.1016/j.jchf.2017.07.014

    Article  Google Scholar 

  2. Sweeting J, Semsarian C (2018) Sudden Cardiac Death in Athletes. Hear Lung Circ 27:1072–1077. https://doi.org/10.1016/j.hlc.2018.03.026

    Article  Google Scholar 

  3. Maron BJ, Thompson PD, Puffer JC, McGrew CA, Strong WB, Douglas PS et al (1996) Cardiovascular preparticipation screening of competitive athletes: a statement for health professionals from the Sudden Death Committee (Clinical cardiology) and Congenital Cardiac Defects Committee (Cardiovascular disease in the young). Circulation 94:850–856. https://doi.org/10.1161/01.CIR.94.4.850

    Article  CAS  PubMed  Google Scholar 

  4. Pilmer CM, Kirsh JA, Hildebrandt D, Krahn AD, Gow RM (2014) Sudden cardiac death in children and adolescents between 1 and 19 years of age. Hear Rhythm 11:239–245. https://doi.org/10.1016/j.hrthm.2013.11.006

    Article  Google Scholar 

  5. Priori SG, Blomström-Lundqvist C, Mazzanti A, Blom N, Borggrefe M, Camm J et al (2016) 2015 ESC guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death. Russ J Cardiol 135:5–86. https://doi.org/10.15829/1560-4071-2016-7-5-86

    Article  Google Scholar 

  6. Meyer L, Stubbs B, Fahrenbruch C, Maeda C, Harmon K, Eisenberg M et al (2012) Incidence, causes, and survival trends from cardiovascular-related sudden cardiac arrest in children and young adults 0 to 35 years of age: a 30-year review. Circulation 126:1363–1372. https://doi.org/10.1161/CIRCULATIONAHA.111.076810

    Article  PubMed  Google Scholar 

  7. Pérez-Pomares JM, De La Pompa JL, Franco D, Henderson D, Ho SY, Houyel L et al (2016) Congenital coronary artery anomalies: a bridge from embryology to anatomy and pathophysiology—a position statement of the development, anatomy, and pathology ESC Working Group. Cardiovasc Res 109:204–216. https://doi.org/10.1093/cvr/cvv251

    Article  CAS  PubMed  Google Scholar 

  8. Angelini P (2007) Coronary artery anomalies: an entity in search of an identity. Circulation 115:1296–1305. https://doi.org/10.1161/CIRCULATIONAHA.106.618082

    Article  PubMed  Google Scholar 

  9. Maron BJ, Shirani J, Poliac LC, Mathenge R, Roberts WC, Mueller FO (1996) Sudden death in young competitive athletes: clinical, demographic, and pathological profiles. J Am Med Assoc 276:199–204. https://doi.org/10.1001/jama.276.3.199

    Article  CAS  Google Scholar 

  10. Morentin B, Suárez-Mier MP, Monzó A, Molina P, Lucena JS (2019) Sports-related sudden cardiac death due to myocardial diseases on a population from 1–35 years: a multicentre forensic study in Spain. Forensic Sci Res 4:257–266. https://doi.org/10.1080/20961790.2019.1633729

    Article  PubMed  PubMed Central  Google Scholar 

  11. Pelliccia A, Spataro A, Maron BJ (1993) Prospective echocardiographic screening for coronary artery anomalies in 1,360 elite competitive athletes. Am J Cardiol 72:978–979. https://doi.org/10.1016/0002-9149(93)91120-7

    Article  CAS  PubMed  Google Scholar 

  12. Maron BJ, Haas TS, Murphy CJ, Ahluwalia A, Rutten-Ramos S (2014) Incidence and causes of sudden death in U.S. college athletes. J Am Coll Cardiol 63:1636–1643. https://doi.org/10.1016/j.jacc.2014.01.041

    Article  PubMed  Google Scholar 

  13. Wu Q, Zhang L, Zheng J, Zhao Q, Wu Y, Yin K et al (2016) Forensic pathological study of 1656 cases of sudden cardiac death in Southern China. Medicine (United States). https://doi.org/10.1097/MD.0000000000002707

    Article  PubMed  PubMed Central  Google Scholar 

  14. Allouche M, Boudriga N, Ben AH, Banasr A, Shimi M, Gloulou F et al (2013) La mort subite au cours d’une activité sportive en Tunisie : À propos d’une série autopsique de 32 cas. Ann Cardiol Angeiol (Paris) 62:82–88. https://doi.org/10.1016/j.ancard.2012.08.030

    Article  CAS  Google Scholar 

  15. Marijon E, Tafflet M, Celermajer DS, Dumas F, Perier MC, Mustafic H et al (2011) Sports-related sudden death in the general population. Circulation 124:672–681. https://doi.org/10.1161/CIRCULATIONAHA.110.008979

    Article  PubMed  Google Scholar 

  16. Suárez-Mier MP, Aguilera B, Mosquera RM, Sánchez-de-León MS (2013) Pathology of sudden death during recreational sports in Spain. Forensic Sci Int 226:188–196. https://doi.org/10.1016/j.forsciint.2013.01.016

    Article  PubMed  Google Scholar 

  17. Chappex N, Schlaepfer J, Fellmann F, Bhuiyan ZA, Wilhelm M, Michaud K (2015) Sudden cardiac death among general population and sport related population in forensic experience. J Forensic Leg Med 35:62–68. https://doi.org/10.1016/j.jflm.2015.07.004

    Article  PubMed  Google Scholar 

  18. Finocchiaro G, Papadakis M, Robertus JL, Dhutia H, Steriotis AK, Tome M et al (2016) Etiology of sudden death in sports insights from a United Kingdom Regional Registry. J Am Coll Cardiol 67:2108–2115. https://doi.org/10.1016/j.jacc.2016.02.062

    Article  PubMed  Google Scholar 

  19. Corrado D, Basso C, Pavei A, Michieli P, Schiavon M, Thiene G (2006) Trends in sudden cardiovascular death in young competitive athletes after implementation of a preparticipation screening program. J Am Med Assoc 296:1593–1601. https://doi.org/10.1001/jama.296.13.1593

    Article  CAS  Google Scholar 

  20. Burke AP, Farb A, Virmani R, Goodin J, Smialek JE (1991) Sports-related and non-sports-related sudden cardiac death in young adults. Am Heart J 121:568–575. https://doi.org/10.1016/0002-8703(91)90727-Y

    Article  CAS  PubMed  Google Scholar 

  21. Solberg EE, Gjertsen F, Haugstad E, Kolsrud L (2010) Sudden death in sports among young adults in Norway. Eur J Prev Cardiol 17:337–341. https://doi.org/10.1097/HJR.0b013e328332f8f7

    Article  Google Scholar 

  22. Fornes P, Lecomte D (2003) Pathology of sudden death during recreational sports activity: an autopsy study of 31 cases. Am J Forensic Med Pathol 24:9–16. https://doi.org/10.1097/00000433-200303000-00002

    Article  PubMed  Google Scholar 

  23. Drory Y, Turetz Y, Hiss Y, Lev B, Fisman EZ, Pines A et al (1991) Sudden unexpected death in persons <40 years of age. Am J Cardiol 68:1388–1392. https://doi.org/10.1016/0002-9149(91)90251-F

    Article  CAS  PubMed  Google Scholar 

  24. Harmon KG, Zigman M, Drezner JA (2015) The effectiveness of screening history, physical exam, and ECG to detect potentially lethal cardiac disorders in athletes: a systematic review/meta-analysis. J Electrocardiol 48:329–338. https://doi.org/10.1016/j.jelectrocard.2015.02.001

    Article  PubMed  Google Scholar 

  25. Quigley F (2000) A survey of the causes of sudden death in sport in the Republic of Ireland. Br J Sports Med 34:258–261. https://doi.org/10.1136/bjsm.34.4.258

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  26. Gräni C, Chappex N, Fracasso T, Vital C, Kellerhals C, Schmied C et al (2016) Sports-related sudden cardiac death in Switzerland classified by static and dynamic components of exercise. Eur J Prev Cardiol 23:1228–1236. https://doi.org/10.1177/2047487316632967

    Article  PubMed  Google Scholar 

  27. Eckart RE, Scoville SL, Campbell CL, Shry EA, Stajduhar KC, Potter RN et al (2004) Sudden death in young adults: a 25-year review of autopsies in military recruits. Ann Intern Med 141:829–834. https://doi.org/10.7326/0003-4819-141-11-200412070-00005

    Article  PubMed  Google Scholar 

  28. Corrado D, Thiene G, Cocco P, Frescura C (1992) Non-atherosclerotic coronary artery disease and sudden death in the young. Heart 68:601–607. https://doi.org/10.1136/hrt.68.12.601

    Article  CAS  Google Scholar 

  29. Camp SPV, Bloor CM, Mueller FO, Cantu RC, Olson HG (1995) Nontraumatic sports death in high school and college athletes. Med Sci Sports Exerc 27:641–647. https://doi.org/10.1249/00005768-199505000-00005

    Article  PubMed  Google Scholar 

  30. Holst AG, Winkel BG, Theilade J, Kristensen IB, Thomsen JL, Ottesen GL et al (2010) Incidence and etiology of sports-related sudden cardiac death in DenmarkImplications for preparticipation screening. Hear Rhythm 7:1365–1371. https://doi.org/10.1016/j.hrthm.2010.05.021

    Article  Google Scholar 

  31. De Noronha SV, Behr ER, Papadakis M, Ohta-Ogo K, Banya W, Wells J et al (2014) The importance of specialist cardiac histopathological examination in the investigation of young sudden cardiac deaths. Europace 16:899–907. https://doi.org/10.1093/europace/eut329

    Article  PubMed  Google Scholar 

  32. De Noronha SV, Sharma S, Papadakis M, Desai S, Whyte G, Sheppard MN (2009) Aetiology of sudden cardiac death in athletes in the United Kingdom: a pathological study. Heart 95:1409–1414. https://doi.org/10.1136/hrt.2009.168369

    Article  PubMed  Google Scholar 

  33. Harmon KG, Drezner JA, Maleszewski JJ, Lopez-Anderson M, Owens D, Prutkin JM et al (2014) Pathogeneses of sudden cardiac death in national collegiate athletic association athletes. Circ Arrhythmia Electrophysiol 7:198–204. https://doi.org/10.1161/CIRCEP.113.001376

    Article  Google Scholar 

  34. Pelliccia A, Sharma S, Gati S, Bäck M, Börjesson M, Caselli S et al (2021) 2020 ESC Guidelines on sports cardiology and exercise in patients with cardiovascular disease. Eur Heart J 42:17–96. https://doi.org/10.1093/eurheartj/ehaa605

    Article  CAS  PubMed  Google Scholar 

  35. Maron BJ, Doerer JJ, Haas TS, Tierney DM, Mueller FO (2009) Sudden deaths in young competitive athletes analysis of 1866 deaths in the united states, 1980–2006. Circulation 119:1085–1092. https://doi.org/10.1161/CIRCULATIONAHA.108.804617

    Article  PubMed  Google Scholar 

  36. Corrado D, Basso C, Rizzoli G, Schiavon M, Thiene G (2003) Does sports activity enhance the risk of sudden death in adolescents and young adults? J Am Coll Cardiol 42:1959–1963. https://doi.org/10.1016/j.jacc.2003.03.002

    Article  PubMed  Google Scholar 

  37. Bohm P, Scharhag J, Meyer T (2016) Data from a nationwide registry on sports-related sudden cardiac deaths in Germany. Eur J Prev Cardiol 23:649–656. https://doi.org/10.1177/2047487315594087

    Article  PubMed  Google Scholar 

  38. Lee AC, Foster E, Yeghiazarians Y (2006) Anomalous origin of the left coronary artery from the pulmonary artery: a case series and brief review. Congenit Heart Dis 1:111–115. https://doi.org/10.1111/j.1747-0803.2006.00017.x

    Article  PubMed  Google Scholar 

  39. Menke DM, Waller BF, Pless JE (1985) Hypoplastic coronary arteries and high takeoff position of the right coronary ostium. A fatal combination of congenital coronary artery anomalies in an amateur athlete. Chest 88:299–301. https://doi.org/10.1378/chest.88.2.299

    Article  CAS  PubMed  Google Scholar 

  40. Cutler D, Wallace JM (1997) Myocardial bridging in a young patient with sudden death. Clin Cardiol 20:581–583. https://doi.org/10.1002/clc.4960200614

    Article  CAS  PubMed  Google Scholar 

  41. Chiu CZ, Shyu KG, Cheng JJ, Lin SC, Lee SH, Hung HF et al (2008) Angiographic and clinical manifestations of coronary fistulas in Chinese people—15-year experience. Circ J 72:1242–1248. https://doi.org/10.1253/circj.72.1242

    Article  PubMed  Google Scholar 

  42. Frommelt PC (2009) Congenital coronary artery abnormalities predisposing to sudden cardiac death. Pacing Clin Electrophysiol (PACE). https://doi.org/10.1111/j.1540-8159.2009.02387.x

    Article  Google Scholar 

  43. Davis JA, Cecchin F, Jones TK, Portman MA (2001) Major coronary artery anomalies in a pediatric population: incidence and clinical importance. J Am Coll Cardiol 37:593–597. https://doi.org/10.1016/S0735-1097(00)01136-0

    Article  CAS  PubMed  Google Scholar 

  44. Cheezum MK, Liberthson RR, Shah NR, Villines TC, O’Gara PT, Landzberg MJ et al (2017) Anomalous aortic origin of a coronary artery from the inappropriate sinus of Valsalva. J Am Coll Cardiol 69:1592–1608. https://doi.org/10.1016/j.jacc.2017.01.031

    Article  PubMed  Google Scholar 

  45. Basso C, Maron BJ, Corrado D, Thiene G (2000) Clinical profile of congenital coronary artery anomalies with origin from the wrong aortic sinus leading to sudden death in young competitive athletes. J Am Coll Cardiol 35:1493–1501. https://doi.org/10.1016/S0735-1097(00)00566-0

    Article  CAS  PubMed  Google Scholar 

  46. Cheitlin MD, MacGregor J (2009) Congenital anomalies of coronary arteries: role in the pathogenesis of sudden cardiac death. Herz 34:268–279. https://doi.org/10.1007/s00059-009-3239-0

    Article  PubMed  Google Scholar 

  47. Brothers JA, Frommelt MA, Jaquiss RDB, Myerburg RJ, Fraser CD, Tweddell JS (2017) Expert consensus guidelines: anomalous aortic origin of a coronary artery. J Thorac Cardiovasc Surg 153:1440–1457. https://doi.org/10.1016/j.jtcvs.2016.06.066

    Article  PubMed  Google Scholar 

  48. Houyel L, Planché C (2002) Trajets coronaires interartériel et intramural: aspects anatomiques et implications chirurgicales. Arch Mal Coeur Vaiss 95:500–506

    CAS  PubMed  Google Scholar 

  49. Molossi S, Martínez-Bravo LE, Mery CM (2019) Anomalous aortic origin of a coronary artery. Methodist Debakey Cardiovasc J 15:111–121. https://doi.org/10.14797/mdcj-15-2-111

    Article  PubMed  PubMed Central  Google Scholar 

  50. Brothers J, Carter C, McBride M, Spray T, Paridon S (2010) Anomalous left coronary artery origin from the opposite sinus of Valsalva: evidence of intermittent ischemia. J Thorac Cardiovasc Surg. https://doi.org/10.1016/j.jtcvs.2009.06.029

    Article  PubMed  Google Scholar 

  51. Angelini P (2011) Sudden death and coronary anomalies: the importance of a detailed description. Texas Hear Inst J 38:544–546

    Google Scholar 

  52. Greet B, Quinones A, Srichai M, Bangalore S, Roswell RO (2012) Anomalous right coronary artery and sudden cardiac death. Circ Arrhythmia Electrophysiol. https://doi.org/10.1161/CIRCEP.112.978635

    Article  Google Scholar 

  53. Angelini P, Velasco JA, Ott D, Khoshnevis GR (2003) Anomalous coronary artery arising from the opposite sinus: descriptive features and pathophysiologic mechanisms, as documented by intravascular ultrasonography. J Invasive Cardiol 15:507–514

    PubMed  Google Scholar 

  54. Angelini P, Walmsley RP, Libreros A, Ott DA (2006) Symptomatic anomalous origination of the left coronary artery from the opposite sinus of Valsalva: clinical presentations, diagnosis, and surgical repair. Texas Hear Inst J 33:171–179

    Google Scholar 

  55. Angelini P, Uribe C, Monge J, Tobis JM, Elayda MA, Willerson JT (2015) Origin of the right coronary artery from the opposite sinus of Valsalva in adults: characterization by intravascular ultrasonography at baseline and after stent angioplasty. Catheter Cardiovasc Interv 86:199–208. https://doi.org/10.1002/ccd.26069

    Article  PubMed  PubMed Central  Google Scholar 

  56. Jo Y, Uranaka Y, Iwaki H, Matsumoto J, Koura T, Negishi K et al (2011) Sudden cardiac arrest: associated with anomalous origin of the right coronary artery from the left main coronary artery. Texas Hear Inst J 38:539–543

    Google Scholar 

  57. Mery CM, Lawrence SM, Krishnamurthy R, Sexson-Tejtel SK, Carberry KE, McKenzie ED et al (2014) Anomalous aortic origin of a coronary artery: toward a standardized approach. Semin Thorac Cardiovasc Surg 26:110–122. https://doi.org/10.1053/j.semtcvs.2014.08.001

    Article  PubMed  Google Scholar 

  58. Tsujita K, Maehara A, Mintz GS, Franklin-Bond T, Mehran R, Stone GW et al (2009) In vivo intravascular ultrasonic assessment of anomalous right coronary artery arising from left coronary sinus. Am J Cardiol 103:747–751. https://doi.org/10.1016/j.amjcard.2008.11.016

    Article  PubMed  Google Scholar 

  59. Carboni GP, Sedati P (2012) Inducible myocardial ischaemia and anomalous origin of the right coronary artery coursing between the aorta and pulmonary artery: a rare, sinister entity. BMJ Case Rep. https://doi.org/10.1136/bcr.02.2012.5884

    Article  PubMed  PubMed Central  Google Scholar 

  60. Formato GM, Lo-Rito M, Auricchio F, Frigiola A, Conti M (2018) Aortic expansion induces lumen narrowing in anomalous coronary arteries: a parametric structural finite element analysis. J Biomech Eng. https://doi.org/10.1115/1.4040941

    Article  PubMed  Google Scholar 

  61. Chu E, Cheitlin MD (1993) Diagnostic considerations in patients with suspected coronary artery anomalies. Am Heart J 126:1427–1438. https://doi.org/10.1016/0002-8703(93)90543-I

    Article  CAS  PubMed  Google Scholar 

  62. Angelini P, Flamm SD (2007) Newer concepts for imaging anomalous aortic origin of the coronary arteries in adults. Catheter Cardiovasc Interv 69:942–954. https://doi.org/10.1002/ccd.21140

    Article  PubMed  Google Scholar 

  63. Zeppilli P, Dello Russo A, Santini C, Palmieri V, Natale L, Giordano A et al (1998) In vivo detection of coronary artery anomalies in asymptomatic athletes by echocardiographic screening. Chest 114:89–93. https://doi.org/10.1378/chest.114.1.89

    Article  CAS  PubMed  Google Scholar 

  64. Daimon M, Watanabe H, Yamagishi H, Muro T, Akioka K, Hirata K et al (2001) Physiologic assessment of coronary artery stenosis by coronary flow reserve measurements with transthoracic Doppler echocardiography: comparison with exercise thallium-201 single-photon emission computed tomography. J Am Coll Cardiol 37:1310–1315. https://doi.org/10.1016/S0735-1097(01)01167-6

    Article  CAS  PubMed  Google Scholar 

  65. Opolski MP, Pregowski J, Kruk M, Witkowski A, Kwiecinska S, Lubienska E et al (2013) Prevalence and characteristics of coronary anomalies originating from the opposite sinus of Valsalva in 8,522 patients referred for coronary computed tomography angiography. Am J Cardiol 111:1361–1367. https://doi.org/10.1016/j.amjcard.2013.01.280

    Article  PubMed  Google Scholar 

  66. Angelini P, Cheong BY, Lenge De Rosen VV, Lopez JA, Uribe C, Masso AH et al (2018) Magnetic resonance imaging-based screening study in a general population of adolescents. J Am Coll Cardiol 71:579–580. https://doi.org/10.1016/j.jacc.2017.11.051

    Article  PubMed  Google Scholar 

  67. De Oliveira DMH, Gomes V, Caramori P (2012) Intravascular ultrasound and pharmacological stress test to evaluate the anomalous origin of the right coronary artery. J Invasive Cardiol 24(6):E131–E134

    PubMed  Google Scholar 

  68. Bigler MR, Ashraf A, Seiler C, Praz F, Ueki Y, Windecker S et al (2021) Hemodynamic relevance of anomalous coronary arteries originating from the opposite sinus of Valsalva-in search of the evidence. Front Cardiovasc Med 7:591326. https://doi.org/10.3389/fcvm.2020.591326

    Article  PubMed  PubMed Central  Google Scholar 

  69. Lee SE, Yu CW, Park K, Park KW, Suh JW, Cho YS et al (2016) Physiological and clinical relevance of anomalous right coronary artery originating from left sinus of Valsalva in adults. Heart 102:114–119. https://doi.org/10.1136/heartjnl-2015-308488

    Article  CAS  PubMed  Google Scholar 

  70. Häner JD, Bär S, Ueki Y, Otsuka T, Gräni C, Räber L (2020) Novel Diagnostic approach to invasively confirm interarterial course of anomalous right coronary artery. JACC Cardiovasc Interv 13:132–134. https://doi.org/10.1016/j.jcin.2019.08.008

    Article  PubMed  Google Scholar 

  71. Driesen BW, Warmerdam EG, Sieswerda GJT, Schoof PH, Meijboom FJ, Haas F et al (2018) Anomalous coronary artery originating from the opposite sinus of Valsalva (ACAOS), fractional flow reserve- and intravascular ultrasound-guided management in adult patients. Catheter Cardiovasc Interv 92:68–75. https://doi.org/10.1002/ccd.27578

    Article  PubMed  Google Scholar 

  72. Lim MJ, Forsberg MJ, Lee R, Kern MJ (2004) Hemodynamic abnormalities across an anomalous left main coronary artery assessment: evidence for a dynamic ostial obstruction. Catheter Cardiovasc Interv 63:294–298. https://doi.org/10.1002/ccd.20182

    Article  PubMed  Google Scholar 

  73. Poynter JA, Williams WG, McIntyre S, Brothers JA, Jacobs ML, Overman D et al (2014) Anomalous aortic origin of a coronary artery: a report from the Congenital Heart Surgeons Society Registry. World J Pediatr Congenit Hear Surg 5:22–30. https://doi.org/10.1177/2150135113516984

    Article  Google Scholar 

  74. Baumgartner H, De Backer J, Babu-Narayan SV, Budts W, Chessa M, Diller GP et al (2021) 2020 ESC Guidelines for the management of adult congenital heart disease. Eur Heart J 42:563–645. https://doi.org/10.1093/eurheartj/ehaa554

    Article  CAS  PubMed  Google Scholar 

  75. Amado J, Carvalho M, Ferreira W, Gago P, Gama V, Bettencourt N (2016) Coronary arteries anomalous aortic origin on a computed tomography angiography population: prevalence, characteristics and clinical impact. Int J Cardiovasc Imaging 32:983–990. https://doi.org/10.1007/s10554-016-0849-5

    Article  PubMed  Google Scholar 

  76. Stout KK, Daniels CJ, Aboulhosn JA, Bozkurt B, Broberg CS, Colman JM et al (2019) 2018 AHA/ACC guideline for the management of adults with congenital heart disease: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. Circulation 139:e698-800. https://doi.org/10.1161/CIR.0000000000000603

    Article  PubMed  Google Scholar 

  77. Hariharan R, Kacere RD, Angelini P (2002) Can stent-angioplasty be a valid alternative to surgery: when revascularization is indicated for anomalous origination of a coronary artery from the opposite sinus? Texas Hear Inst J 29:308–313

    Google Scholar 

  78. Romp RL, Herlong JR, Landolfo CK, Sanders SP, Miller CE, Ungerleider RM et al (2003) Outcome of unroofing procedure for repair of anomalous aortic origin of left or right coronary artery. Ann Thorac Surg 76:589–596. https://doi.org/10.1016/S0003-4975(03)00436-3

    Article  PubMed  Google Scholar 

  79. Unzué L, García E, López-Melgar B, Agudo-Quilez P (2018) Percutaneous treatment of an anomalous left main arising from the opposite sinus with subpulmonic course. Cardiovasc Revasc Med 19:632–637. https://doi.org/10.1016/j.carrev.2018.01.008

    Article  PubMed  Google Scholar 

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  1. Marco Schiavone and Cecilia Gobbi contributed equally to this manuscript.

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  1. Cardiology Unit, ASST Fatebenefratelli Sacco - Luigi Sacco University Hospital, University of Milan, Via G.B. Grassi, 74, 20157, Milan, Italy

    Marco Schiavone, Alessio Gasperetti & Giovanni Battista Forleo

  2. Department of Cardiology, Saint Martin Private Hospital Center, Caen, France

    Cecilia Gobbi & Andrea Zuffi

  3. Division of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA

    Alessio Gasperetti

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Schiavone, M., Gobbi, C., Gasperetti, A. et al. Congenital Coronary Artery Anomalies and Sudden Cardiac Death. Pediatr Cardiol 42, 1676–1687 (2021). https://doi.org/10.1007/s00246-021-02713-y

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