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Rapid Improvement of Pulmonary Functions in Children After Transcatheter Closure of an Atrial Septal Defect

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Abstract

There are very few studies in the literature on respiratory system functions and complications of children with an atrial septal defect (ASD). The aim of this study is to investigate the pulmonary functions and pulmonary complications before and after transcatheter closure in children with an ASD. In this study, pulmonary function test parameters of 30 ASD patients between 5 and 18 years of age who were eligible to be treated by transcatheter ASD closure were compared with 30 healthy children. The patients undergoing transcatheter ASD closure received pulmonary function tests (PFT) at baseline (1 day before ASD closure), and 3 months after the procedure. Forced vital capacity (FVC), forced expired volume in 1 s (FEV1), peak expiratory flow, and mean forced expiratory flow during the middle half of FVC were measured. The mean age of the 30 ASD patients was 9.59 ± 3.1 years; and 20 (66.6%) were female and 10 (33.3%) were male. The mean age of the control group was 10.15 ± 2.21 years, and 19 (63.3%) were girls and 11 (36.6%) were males. ASD patients had significantly reduced FVC (73.11 ± 24.6%; 86.05 ± 26.1; p = 0.001, respectively), and FEV1 (81.34 ± 26.2% and 99.2 ± 19.6%; p = 0.001; respectively) at baseline. But significant improvement was observed in FVC values in the 3rd-month post-closure comparison of the patient group with the control group (73.11 ± 24.6%; and 88.36 ± 14.5%; p = 0.01, respectively); FEV1 values (81.34 ± 26% and 99.54 ± 18.2%; p = 0.005, respectively) and mean forced expiratory flow between 25 and 75% of vital capacity (MEF25–75) values (94.6 ± 33.4% and 124.2 ± −24.1%; p = 0.01, respectively) were also improved. There was no statistically significant relationship between the PFT measurements at baseline and after closure of the defect and age at transcatheter closure, gender, body height, body weight, ASD diameter, Q p/Q s, right ventricle systolic pressure, or mean pulmonary artery pressure values. At the 3rd month of ASD closure, there was no significant difference in the comparison of the PFT values of the patient and control group. Disturbance in the significant flow limitation of the peripheral airway of ASD patients was observed with PFT. Better pulmonary outcomes were observed in ASD patients after transcatheter closure.

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References

  1. Anderson RH, Edward J, Baker EJ et al (2010) Pediatric cardiology, 3rd edn. Churchill Livingstone, London. ISBN 978-0-7020-3064-2

    Google Scholar 

  2. Graham TP Jr (1991) Ventricular performance in congenital heart disease. Circulation 84:2259–2274

    Article  PubMed  Google Scholar 

  3. Cowen ME, Jeffrey RR, Drakeley MJ et al (1990) The results of surgery for atrial septal defect in patients aged fifty years and over. Eur Heart J 11:29–34

    Article  CAS  PubMed  Google Scholar 

  4. Yoshioka T, Kunieda T, Naito M et al (1985) Effects of pulmonary hemodynamics on lung function in adult patients with atrial septal defect. Jpn Circ J 49:960–966

    Article  CAS  PubMed  Google Scholar 

  5. Miller MR, Hankinson J, Brusasco V et al (2005) Standardisation of spirometry. Eur Respir J 26:319–338

    Article  CAS  PubMed  Google Scholar 

  6. Beydon N, Davis SD, Lombardi E et al (2007) An official American Thoracic Society/European Respiratory Society statement: pulmonary function testing in preschool children. Am J Respir Crit Care Med 175:1304–1345

    Article  PubMed  Google Scholar 

  7. Fischer G, Kramer HH, Stieh J et al (1999) Transcatheter closure of secundum atrial septal defects with the new self-centering Amplatzer Septal Occluder. Eur Heart J 20:541–549

    Article  CAS  PubMed  Google Scholar 

  8. Sulc J, Andrle V, Hruda J et al (1998) Pulmonary function in children with atrial septal defect before and after heart surgery. Heart 80:484–488

    Article  CAS  PubMed  Google Scholar 

  9. Lee YS, Jeng MJ, Tsao PC et al (2009) Pulmonary function changes in children after transcatheter closure of atrial septal defect. Pediatr Pulmonol 44:1025–1032

    Article  PubMed  Google Scholar 

  10. Healy F, Hanna B, Zinman R (2012) Pulmonary complications of congenital heart disease. Paediatr Respir Rev 13:10–15

    Article  CAS  PubMed  Google Scholar 

  11. Bucci G, Cook CD, Hamann JF (1961) Studies of respiratory physiology in children. Lung diffusing capacity, diffusing capacity of the pulmonary membrane and pulmonary capillary blood volume in congenital heart disease. J Clin Investig 8(Pt 1–2):1431–1441. https://doi.org/10.1172/JCI104374

    Article  Google Scholar 

  12. Kocis KC, Meliones JN (2000) Cardiopulmonary interactions in children with congenital heart disease: physiology and clinical correlates. Prog Pediatr Cardiol 11:203–210

    Article  CAS  PubMed  Google Scholar 

  13. Alonso-Gonzalez R, Borgia F, Diller G-P et al (2013) Abnormal lung function in adults with congenital heart disease: prevalence, relation to cardiac anatomy, and association with survival. Circulation 127(8):882–890

    Article  PubMed  Google Scholar 

  14. Wallgren G, Geubelle F, Koch G (1960) Studies of the mechanics of breathing in children with congenital heart lesions. Acta Paediatrica 49:415–425

    Article  CAS  PubMed  Google Scholar 

  15. Wang EE, Law BJ, Stephens D (1995) Pediatric Investigators Collaborative Network on Infections in Canada (PICNIC) prospective study of risk factors and outcomes in patients hospitalized with respiratory syncytial viral lower respiratory tract infection. J Pediatr 126:212–219

    Article  CAS  PubMed  Google Scholar 

  16. Engelfriet PM, Duffels MG, Moller T et al (2007) Pulmonary arterial hypertension in adults born with a heart septal defect: the Euro Heart Survey on adult congenital heart disease. Heart 93:682–687

    Article  PubMed  Google Scholar 

  17. Rosenthal DN, Friedman AH, Kleinman CS et al (1995) Thromboembolic complications after Fontan operations. Circulation 92:287–293

    Article  Google Scholar 

  18. Mahar T, Katzman P, Alfieris G (2009) A case of fatal septic pulmonary embolus arising from an infected Sano conduit. Pediatr Cardiol 30:181–183

    Article  PubMed  Google Scholar 

  19. Vogel M, Berger F, Kramer A et al (1999) Incidence of secondary pulmonary hypertension in adults with atrial septal or sinus venosus defects. Heart 82:30–33

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  20. Sachweh JS, Daebritz SH, Hermanns B et al (2006) Hypertensive pulmonary vascular disease in adults with secundum or sinus venosus atrial septal defect. Ann Thorac Surg 81:207–213

    Article  PubMed  Google Scholar 

  21. Schoen SP, Kittner T, Bohl S et al (2006) Transcatheter closure of atrial septal defects improves right ventricular volume, mass, function, pulmonary pressure, and functional class: a magnetic resonance imaging study. Congenit Heart Dis 92:821–826

    CAS  Google Scholar 

  22. Murphy JG, Gersh BJ, McGoon MD et al (1990) Long-term outcome after surgical repair of isolated atrial septal defect. Follow-up at 27 to 32 years. N Engl J Med 323:1645–1650

    Article  CAS  PubMed  Google Scholar 

  23. Zaqout M, De Baets F, Schelstraete P et al (2010) Pulmonary function in children after surgical and percutaneous closure of atrial septal defect. Pediatr Cardiol 20(31):1171–1175

    Article  Google Scholar 

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Funding

This research has received no specific grant from any funding agency or from commercial or non-profit organizations.

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Authors and Affiliations

  1. Department of Pediatric Cardiology, Faculty of Medicine, Inonu University, Malatya, Turkey

    Serkan F. Çelik & Cemşit Karakurt

  2. Department of Pediatrics, Faculty of Medicine, Inonu University, Malatya, Turkey

    Nurdan Yıldırım Acar

  3. Department of Pediatrics, Magnet Hospital, Kayseri, Turkey

    Elif Çelik

Authors
  1. Serkan F. Çelik
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  2. Cemşit Karakurt
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  3. Nurdan Yıldırım Acar
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  4. Elif Çelik
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Correspondence to Serkan F. Çelik.

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The authors assert that all the procedures contributing to this work comply with the ethical standards of the relevant national guidelines on human experimentation and with the Helsinki Declaration of 1975 as revised in 2008, and has been approved by the institutional committees of Inönü University/Turkey.

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Çelik, S.F., Karakurt, C., Acar, N.Y. et al. Rapid Improvement of Pulmonary Functions in Children After Transcatheter Closure of an Atrial Septal Defect. Pediatr Cardiol 39, 329–334 (2018). https://doi.org/10.1007/s00246-017-1759-6

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  • DOI: https://doi.org/10.1007/s00246-017-1759-6

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