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Association between urinary lithiasis, other than struvite by crystallography and non-ureolytic bacteria

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Abstract

The relationship between urinary tract infection caused by urease-producing bacteria and lithiasis due to struvite stones is well established in the literature. However, there is limited knowledge on whether non-urease producing bacteria can also promote crystallization. In our study, we analyzed the association between urinary lithiasis, other than struvite by crystallography and non-ureolytic bacteria, in 153 patients who underwent surgery for urinary stone. The collected samples were sent for crystallographic analysis and culture. Additionally, preoperatory urine culture was collected for combined evaluation with the previous data. Percutaneous nephrolithotomy was the most commonly performed approach (45.8%). Struvite stones were more frequently identified in women (90.3%). Among stones with positive cultures, except struvite, 45.5% were composed of calcium oxalate monohydrate. The difference between urine culture and stone culture was different in 24.8% of the cases. Among stones with positive cultures that did not contain struvite, 86.4% showed non-urease bacteria in their cultures and 47.1% of struvite stones also did not have urease-producing bacteria in their cultures (p < 0.021). Our findings suggest that there is an association between non-ureolytic bacteria and stones that are not composed of struvite.

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Abbreviations

AMP:

Ammonium magnesium phosphate

CC:

Calculi culture

CC−:

Negative calculi culture

CC+:

Positive calculi culture

COD:

Calcium oxalate dihydrate

COM:

Calcium oxalate monohydrate

MIXED:

Double composition, except struvite

PCNL:

Percutaneous nephrolithotomy

PCP:

Pure calcium phosphate

SIRS:

Systemic inflammatory response syndrome

ST−:

Negative struvite

ST+:

Positive struvite

UC:

Urine culture

UHS:

Unified health system

URIC:

Uric acid

UTI:

Urinary tract infection

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Acknowledgements

The authors acknowledge Dr. Tamara da Silva Cunha for her invaluable contribution in carrying out all crystallographic analyses.

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Authors and Affiliations

  1. Federal University of Rio de Janeiro, Rio de Janeiro, Brazil

    Jackson da Cruz Machado, Juan Miguel Renteria, Marcelo Medeiros do Nascimento, Gabriel Marin Vieira & José Eduardo Ferreira Manso

  2. Federal Hospital of Ipanema, Rio de Janeiro, Brazil

    Antônio Claudio Ahouagi Cunha

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  1. Jackson da Cruz Machado
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  3. Marcelo Medeiros do Nascimento
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  4. Antônio Claudio Ahouagi Cunha
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Contributions

It is declared that all authors listed in this study contributed intensely to the preparation, execution, data manipulation, writing of the work and critical reading. J.C.M - wrote the main manuscript text, contributed to the preparation of the project, data collection. M.M.D.N - contributed to the preparation of the project, data collection and manuscript text. J.M.R - coordinated the project since its preparation, participated in data collection and contributed to the critical review of the written work. J.E.F.M - coordinated the project since its preparation, participated in data collection and contributed to the critical review of the written work. G.M.V - contributed to the preparation of the project and data collection. A.C.A.C - contributed to the preparation of the project and data collection

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Correspondence to Jackson da Cruz Machado.

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da Cruz Machado, J., Miguel Renteria, J., Medeiros do Nascimento, M. et al. Association between urinary lithiasis, other than struvite by crystallography and non-ureolytic bacteria. Urolithiasis 52, 28 (2024). https://doi.org/10.1007/s00240-023-01525-4

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