Abstract
This review examines data from stone conferences and research journals to assess whether justifiable concerns exist about possible bias in urolithiasis research and if so, how they can be minimized. Conflict of interest (COI) policies of two major urological congresses and three symposia dedicated to stone research were reviewed. Disclosure slides were viewed in webcasts and were evaluated for robustness and speaker compliance with respect to policy. Additionally, disclosure and COI policies of ten Science Citation Index (SCI)-approved journals were assessed and compared with actual declarations in published papers on urolithiasis. It was observed that disclosure and conflict declarations are frequently conflated in congresses and journals. Differences between the two ideologies appear to be ignored or unappreciated. Disclosures in the major urological meetings revealed a high percentage of financial relationships with industry. In dedicated stone conferences, more than two-thirds of speakers failed to display a declaration slide. Both scenarios generate questions about objectivity. Disclosure and COI statements in journals varied widely in format, detail and content. It is concluded that there exists a misinformed and incorrect perception in urolithiasis research that disclosure of potential COIs somehow validates a study as being objective and unbiased. Current policies and practices at conferences and in published papers create a setting in which concerns of bias prevail. Changes, including the establishment of a universal policy, insistence of independent and explicit declarations of disclosures and conflicts, implementation of sanctions for transgression and the introduction of intensive scrutiny by reviewers are required to minimize doubts.
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References which substantiate individual cases cited in this review can be provided on request.
Change history
01 February 2023
A Correction to this paper has been published: https://doi.org/10.1007/s00240-023-01409-7
References
Schoenthaler M, Miernik A, Wilhelm K, Schlager D, Schoeb DS, Adams F, Dahm P, Hein S (2016) Level of evidence, sponsorship, conflict of interest policy and commercial impact of PubMed-listed clinical urolithiasis-related trials in 2014. BJU Int 117:787–792
Dunn AG, Coiera E, Mandl KD, Bourgeois FT (2016) Conflict of interest disclosure in biomedical research: a review of current practices, biases, and the role of public registries in improving transparency. Res Integ Peer Rev 1:1–8
Agrawal D, Haque W (2019) Transparent disclosure of conflicts of interest. JAMA 321:1728
Crawford W, Camm CF, Prachee I, Ginks M (2019) Quality of conflicts of interest declarations in a conference setting–are audiences given a chance to adequately assess bias? Heart 105:A96–A97
Le Roux A, Touma NJ (2022) The value of conflicts of interest disclosures in oral presentations at major urological conferences. Soc Int Urol J 3:276–279
Laube N, Grabowy U, Busch (2004) Novel analyzer allows rapid determination of urinary calcium oxalate stone formation risk. In: Gohel M, Au D (eds) Kidney Stones: Inside & Out: Proc 10th Int Symp Urolithiasis, Hong Kong, China. Reprographic Unit, Hong Kong Polytechnic University, pp 269
Galan J (2022) New medical device to monitor the urine pH of stone former patients. 14th Meeting of the International Urolithiasis Society in conjunction with the 5th Experts in Stone Disease Conference, June 10–11, Athens, Greece 2022. https://www.youtube.com/watch?v=P8O8gsfa4XA&t=423s. Accessed 28 Aug 2022
10th International Alliance of Urolithiasis Annual Congress (Guangzhou, China, Aug 2021) http://www.iaumembercenter.com/en/col.jsp?id=146. Accessed 19 Sept 2022
The 5th Experts in Stone Disease Conference (Athens, Greece, June 2022) www.esdconference.com. Accessed 28 Aug 2022
The 37th Annual Congress of the European Association of Urology (Section of Urolithiasis EULIS, Amsterdam, The Netherlands, July 2022) https://eaucongress.uroweb.org/. Accessed 16 Sept 2022
American Urological Association (AUA) disclosure form for authors https://www.auajournals.org/pb-assets/media/JU-disclosure-for-authors1555943841437.pdf. Accessed 15 May 2022
AUA2021 Plenary Speaker Disclosures. https://www.aua2021.org/documents/AUA2021/Speaker-Central/AUA201-Plenary-Speaker-Disclosures-Virtual.pdf. Accessed 15 May 2022
European Urology Authorship Responsibility, Financial Disclosure and Acknowledgment Form https://ymlib.yonsei.ac.kr/wp-content/uploads/2018/01/authorshipform.doc. Accessed 16 Sept 2022
Stamatelou K (2022) Primary hyperoxaluria Type 1: Diagnosis, clinical manifestations, complications and medical management in the era of novel therapeutic options. 14th Meeting of the International Urolithiasis Society in conjunction with the 5th Experts in Stone Disease Conference, June 10–11, Athens, Greece 2022. https://www.youtube.com/watch?v=pR-cYAfu9B0. Accessed 19 Sept 2022
Staios D (2022) Management of kidney stones in patients with PH1 – the urologist’s perspective. 14th Meeting of the International Urolithiasis Society in conjunction with the 5th Experts in Stone Disease Conference, June 10–11, Athens, Greece 2022. https://www.youtube.com/watch?v=pR-cYAfu9B0. Accessed 19 Sept 2022
Bauchner H (2019) Editorial comment. JAMA 321:1728
EACCME criteria for the accreditation of live educational events LEE) https://www.uems.eu/__data/assets/pdf_file/0016/40156/EACCME-2-0-CRITERIA-FOR-THE-ACCREDITATION-OF-LEE-Version-6-07-09-16.pdf. Accessed 27 Dec 2022
Baselga J (2018) Failure to disclose conflict of interest in article published in JAMA on detection of cancer-related genes. JAMA 320:2380
World Journal of Urology Submission Guidelines: https://www.springer.com/journal/345/submission-guidelines#Instructions%20for%20Authors_Competing%20Interests. Accessed 20 Nov 2022
Urology Medical Lasers Global Market Report 2022 https://www.globenewswire.com/news-release/2022/05/24/2449024/0/en/Urology-Medical-Lasers-Global-Market-Report-2022.html. . Accessed 27 December 2022
Springer Nature: Editorial Policies https://www.springernature.com/gp/policies/editorial-policies. Accessed 20 Nov 2022
International Committee for Medical Journal Editors (ICMJE): Disclosure of Financial and Non-Financial Relationships and Activities, and Conflicts of Interest: https://www.icmje.org/recommendations/browse/roles-and-responsibilities/author-responsibilities--conflicts-of-interest.html. Accessed 20 Nov 2022
Rodgers A (2022) Are there conflicts of interest in urolithiasis research? Yes! 14th Meeting of the International Urolithiasis Society in conjunction with the 5th Experts in Stone Disease Conference, June 10–11, Athens, Greece 2022. https://www.youtube.com/watch?v=9f1JP1YJICs. Accessed 23 Nov 2022
Trinchieri A (2022) Are there conflicts of interest in urolithiasis research? No! 14th Meeting of the International Urolithiasis Society in conjunction with the 5th Experts in Stone Disease Conference, June 10–11, Athens, Greece 2022. https://youtu.be/bN7vxQawDPs. Accessed 23 Nov 2022
Acknowledgements
The author expresses thanks to the South African National Research Foundation, the South African Medical Research Council and the University of Cape Town for the award of research funding.
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In presenting arguments for this article, there is no intention whatsoever to challenge the integrity of any individual or company. The objective is to arguee that the current modus operandi for ensuring unbiased reporting, although well-intended and applied in good faith, is fundamentally flawed and needs to be revised. The opinions, comments and conclusions presented here are done so in the author's private capacity.
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The author does not have any financial or other relationships relevant to this study. Some of the contents of this review were presented in a podium debate at the 5th Experts in Stone Disease Conference in Athens in June 2022 [23, 24].
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Rodgers, A.L. Conflicts of interest and the risk of bias are inevitable in urolithiasis research. Urolithiasis 51, 24 (2023). https://doi.org/10.1007/s00240-022-01397-0
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DOI: https://doi.org/10.1007/s00240-022-01397-0