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Epidemiological and clinical characteristics of stone composition: a single-center retrospective study

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Abstract

The aim of the study was to investigate the epidemiological characteristics of stone components in patients with urolithiasis and analyze the associations between stone components with patients' clinical characteristics. A total of 7126 patients with urolithiasis between July 2005 and June 2020 were retrospectively analyzed. In this research, calcium oxalate stones (74.6%) accounted for the highest proportion, followed by infection stones (11.8%), uric acid (10.6%), brushite (2.0%), and others (1.1%). The change in trend in the composition of urinary stones revealed that the proportion of uric acid declined steadily, while the content of infection stones increased gradually over 15 years. The results also suggested that stone composition was significantly associated with PM2.5, gender, age, BMI, diabetes, hypertension, CCVD, alcohol consumption, albumin, creatinine, WBCHP, leukocyte, urine pH, nitrite and urine culture (P < 0.05). However, there was no significant correlation between stone composition with smoking, WBC and NEU% (P > 0.05). Our study concluded that calcium oxalate represented the highest proportion, followed by infection stones, uric acid, brushite, and others. The proportion of uric acid declined steadily, while the infection stones increased gradually. Furthermore, the factors influencing the formation of urinary calculi are PM2.5, gender, age, BMI, diabetes, hypertension, CCVD, alcohol consumption, albumin, creatinine, WBCHP, leukocyte, urine pH, nitrite and urine culture. Collectively, these results may provide clues to establish effective prevention and management strategies for urinary calculi.

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References

  1. Scales CD, Smith AC, Hanley JM et al (2012) Prevalence of kidney stones in the United States. Eur Urol 62:160–165

    Article  Google Scholar 

  2. Türk C, Petřík A, Sarica K et al (2016) EAU guidelines on interventional treatment for urolithiasis. Eur Urol 69:475–482

    Article  Google Scholar 

  3. Stamatelou KK, Francis ME, Jones CA et al (2003) Time trends in reported prevalence of kidney stones in the United States: 1976–1994. Kidney Int 63:1817–1823

    Article  Google Scholar 

  4. Hesse A, Brändle E, Wilbert D et al (2003) Study on the prevalence and incidence of urolithiasis in Germany comparing the years 1979 vs. 2000. Eur Urol 44:709–713

    Article  CAS  Google Scholar 

  5. Cheng F, Yu W, Zhang X et al (2010) Minimally invasive tract in percutaneous nephrolithotomy for renal stones. J Endourol 24:1579–1582

    Article  Google Scholar 

  6. Zeng G, Mai Z, Xia S et al (2017) Prevalence of kidney stones in China: an ultrasonography based cross-sectional study. BJU Int 120:109–116

    Article  Google Scholar 

  7. Wu W, Yang B, Ou L et al (2014) Urinary stone analysis on 12,846 patients: a report from a single center in China. Urolithiasis 42:39–43

    Article  Google Scholar 

  8. Ramello A, Vitale C, Marangella M (2000) Epidemiology of nephrolithiasis. J Nephrol 13(Suppl 3):S45–S50

    PubMed  Google Scholar 

  9. Bibilash BS, Vijay A, Fazil Marickar YM (2010) Stone composition and metabolic status. Urol Res 38:211–213

    Article  CAS  Google Scholar 

  10. Morgan MS, Pearle MS (2016) Medical management of renal stones. BMJ 352:i52

    Article  Google Scholar 

  11. Ye Z, Zeng G, Yang H et al (2020) The status and characteristics of urinary stone composition in China. BJU Int 125(6):801–809

  12. Khan SR, Pearle MS, Robertson WG et al (2016) Kidney stones. Nat Rev Dis Primers 2:16008

    Article  Google Scholar 

  13. Gabrielsen JS, Laciak RJ, Frank EL et al (2012) Pediatric urinary stone composition in the United States. J Urol 187:2182–2187

    Article  Google Scholar 

  14. Lieske JC, Rule AD, Krambeck AE et al (2014) Stone composition as a function of age and sex. Clin J Am Soc Nephrol 9:2141–2146

    Article  Google Scholar 

  15. Norsworthy AN, Pearson MM (2017) From catheter to kidney stone: the uropathogenic lifestyle of proteus mirabilis. Trends Microbiol 25:304–315

    Article  CAS  Google Scholar 

  16. Bichler KH, Eipper E, Naber K et al (2002) Urinary infection stones. Int J Antimicrob Ag 19:488–498

    Article  CAS  Google Scholar 

  17. Guohua Z, ZanIin M, Shujie X et al (2015) A cross-sectional survey of urolithiasis prevalence in China. Chinese J Urol 36:528–532

    Google Scholar 

  18. Brien G, Schubert G, Bick C (1982) 10,000 analyses of urinary calculi using X-ray diffraction and polarizing microscopy. Eur Urol 8:251–256

    Article  CAS  Google Scholar 

  19. HERRING LC (1962) Observations on the analysis of ten thousand urinary calculi. J Urol 88:545–562

    Article  CAS  Google Scholar 

  20. Leusmann DB, Blaschke R, Schmandt W (1990) Results of 5035 stone analyses: a contribution to epidemiology of urinary stone disease. Scand J Urol Nephrol 24:205–210

    Article  CAS  Google Scholar 

  21. Huo J, Liu Z, Wang K et al (2015) In vivo evaluation of chemical composition of eight types of urinary calculi using spiral computerized tomography in a Chinese population. J Clin Lab Anal 29:370–374

    Article  CAS  Google Scholar 

  22. Xuebin D, Guiyao L, Zhaofang T et al (2011) Chemical composition of upper urinary tract stones and features of the metabolic disturbance in Sanshui town patients and the prevention. Med Recapitul 17:2540–2542

    Google Scholar 

  23. Xu MX, Qin YT, Ge CX et al (2018) Activated iRhom2 drives prolonged PM(2.5) exposure-triggered renal injury in Nrf2-defective mice. Nanotoxicology 12:1045–1067

    Article  CAS  Google Scholar 

  24. Trinchieri A, Montanari E (2018) Biochemical and dietary factors of uric acid stone formation. Urolithiasis 46:167–172

    Article  CAS  Google Scholar 

  25. Yi L, Mengfan T, Kun Y et al (2019) Research on PM2.5 estimation and prediction method and changing characteristics analysis under long temporal and large spatial scale–a case study in China typical regions. Sci Total Environ. https://doi.org/10.1016/j.scitotenv.2019.133983

    Article  PubMed  Google Scholar 

  26. Wang W, Ma F, Peng R et al (2015) Occurrence and risk factors of composition changes of primary urinary calculi. Chinese J Urol 36:752–756

    CAS  Google Scholar 

  27. Qun, H., Xiaochun, Z., Yanqu, N (2005) Analysis of chemical composition of urinary stones and evaluation of metabolic disturbance in 284 patients. Chinese J Urol (11):42-45

  28. Watson JM, Shrewsberry AB, Taghechian S et al (2010) Serum testosterone may be associated with calcium oxalate urolithogenesis. J Endourol 24:1183–1187

    Article  Google Scholar 

  29. Li JY, Zhou T, Gao X et al (2010) Testosterone and androgen receptor in human nephrolithiasis. J Urol 184:2360–2363

    Article  CAS  Google Scholar 

  30. Strope SA, Wolf JJ, Hollenbeck BK (2010) Changes in gender distribution of urinary stone disease. Urology 75(543–546):541–546

    Google Scholar 

  31. Yasui T, Iguchi M, Suzuki S et al (2008) Prevalence and epidemiological characteristics of urolithiasis in Japan: national trends between 1965 and 2005. Urology 71:209–213

    Article  Google Scholar 

  32. Heilberg IP (2016) Treatment of patients with uric acid stones. Urolithiasis 44:57–63

    Article  CAS  Google Scholar 

  33. Prosiannikov, M. Y., Shaderkin, I. A., Konstantinova, O. V. et al (2019) Remote monitoring of urinalysis parameters during treatment of patients with uric acid stones by citrate-containing compounds. Urologiia (3):60–65

  34. Yamamoto Y, Fujita K, Nakazawa S et al (2012) Clinical characteristics and risk factors for septic shock in patients receiving emergency drainage for acute pyelonephritis with upper urinary tract calculi. Bmc Urol 12:4

    Article  Google Scholar 

  35. Joual A, Fekak H, Rabii R et al (1996) Complications of urinary calculi. Ann Urol (Paris) 30:251–256

    CAS  Google Scholar 

  36. Prywer J, Olszynski M (2017) Bacterially induced formation of infectious urinary stones: recent developments and future challenges. Curr Med Chem 24:292–311

    Article  CAS  Google Scholar 

  37. Carpentier X, Daudon M, Traxer O et al (2009) Relationships between carbonation rate of carbapatite and morphologic characteristics of calcium phosphate stones and etiology. Urology 73(5):968–975

    Article  Google Scholar 

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Acknowledgements

Thanks to Na Li and Xiong Yang for providing data on stone compositions.

Funding

This work was supported by the Science and Technology Project of Tianjin (18PTLCSY00020). Tianjin Health Science and Technology Project (KJ20152).

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Author notes

  1. Xierzhati Aizezi and Linguo Xie have contributed equally to this work.

Authors and Affiliations

  1. Department of Urology, The Second Hospital of Tianjin Medical University, 23 Pingjiang Road, Hexi District, Tianjin, People’s Republic of China

    Xierzhati Aizezi, Linguo Xie, Haijie Xie, Jie Li, Zhiqun Shang & Chunyu Liu

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  1. Xierzhati Aizezi
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  2. Linguo Xie
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  3. Haijie Xie
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Correspondence to Chunyu Liu.

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Aizezi, X., Xie, L., Xie, H. et al. Epidemiological and clinical characteristics of stone composition: a single-center retrospective study. Urolithiasis 50, 37–46 (2022). https://doi.org/10.1007/s00240-021-01274-2

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  • DOI: https://doi.org/10.1007/s00240-021-01274-2

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