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Ancestral Information Analysis of Chinese Korean Ethnic Group via a Novel Multiplex DIP System

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Abstract

Deletion/insertion polymorphism (DIP) is one of the more promising genetic markers in the field of forensic genetics for personal identification and biogeographic ancestry inference. In this research, we used an in-house developed ancestry-informative marker-DIP system, including 56 autosomal diallelic DIPs, three Y-chromosomal DIPs, and an Amelogenin gene, to analyze the genetic polymorphism and ancestral composition of the Chinese Korean group, as well as to explore its genetic relationships with the 26 reference populations. The results showed that this novel panel exhibited high genetic polymorphism in the studied Korean group and could be effectively applied for forensic individual identification in the Korean group. In addition, the results of multiple population genetic analyses indicated that the ancestral component of the Korean group was dominated by northern East Asia. Moreover, the Korean group was more closely related to the East Asian populations, especially to the Japanese population in Tokyo. This study enriched the genetic data of the Korean ethnic group in China and provided information on the ancestry of the Korean group from the perspective of population genetics.

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Acknowledgements

We thank all participants for their contributions to this study.

Funding

The National Key R&D Program of China (2022YFC3302004, 2022YFC3302004-1).

Author information

Authors and Affiliations

  1. Guangzhou Key Laboratory of Forensic Multi-Omics for Precision Identification, School of Forensic Medicine, Southern Medical University, Guangzhou, Guangdong, China

    Meiming Cai, Xi Yuan & Bofeng Zhu

  2. School of Basic Medical Sciences, Shenzhen University Medical School, Shenzhen University, Shenzhen, Guangdong, China

    Shuanglin Li

  3. Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi’an Jiaotong University, Xi’an, Shanxi, China

    Xingru Zhang & Jianfeng Shi

  4. School of Forensic Medicine, Southern Medical University, Guangzhou, Guangdong, China

    Weibing Xie

  5. Department of Forensic Genetics, School of Forensic Medicine, China Medical University, Shenyang, Liaoning, China

    Jun Yao

Authors
  1. Meiming Cai
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  2. Shuanglin Li
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  3. Xingru Zhang
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  6. Xi Yuan
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  7. Jun Yao
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  8. Bofeng Zhu
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Contributions

This study was designed by BZ. MC performed the experiment, analyzed data, visualized corresponding diagrams, and wrote the manuscript. JY collected samples and assisted in data collation and analysis, drafting the manuscript. SL, XZ, WX, JS, XY revised the manuscript to provide the necessary recommendations for research. All authors contributed to data analysis, editing and revision of the manuscript.

Corresponding authors

Correspondence to Jun Yao or Bofeng Zhu.

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Conflict of interest

The authors declare no conflict of interest.

Ethical Approval

Our research was strictly adhered to the principles of human ethics research and was in accordance with the approvals of the Ethics Committees of Southern Medical University and Xi’an Jiaotong University (No. 2019-1039).

Informed Consent

All participants in this study signed the written informed consents before providing samples.

Additional information

Handling editor: Alexander Platt.

Supplementary Information

Below is the link to the electronic supplementary material.

239_2023_10143_MOESM1_ESM.tiff

The cross-validation error of each K value estimated by the ADMIXTURE software for the East Asian populations and the Korean group based on 56 AIM-DIPs. Supplementary file1 (TIFF 185 KB)

239_2023_10143_MOESM2_ESM.tiff

The cross-validation error of each K value estimated by the ADMIXTURE software for the Korean group and 26 reference populations based on 56 AIM-DIPs. Supplementary file2 (TIFF 186 KB)

Supplementary file3 (XLSX 92 KB)

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Cai, M., Li, S., Zhang, X. et al. Ancestral Information Analysis of Chinese Korean Ethnic Group via a Novel Multiplex DIP System. J Mol Evol 91, 922–934 (2023). https://doi.org/10.1007/s00239-023-10143-y

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  • DOI: https://doi.org/10.1007/s00239-023-10143-y

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