Abstract
Background
It is still debatable how congenital melanocityc nevi (CMN) should be treated. Among the treatment options are chemical peeling, partial-thickness and full-thickness excisions of the lesions, dermabrasion, curettage, and laser therapy. Any of the aforementioned methods will lessen the total number of melanocytes; however, the results are usually unsatisfactory. The authors of this study set out to assess the effectiveness of cryocarboxy surgery in the treatment of CMN types II, III, and I. They looked at the histopathological alterations brought on by the use of this therapeutic approach in various forms of CMN.
Methods
Between January 2012 and April 2021, 292 patients with CMNs of various sizes participated in this study. There are three different types of congenital melanocytic nevi. Among the patients’ CMN were 169 as type I (non-hairy), 84 as type II (hairy), and 39 as type III (hypertrophic type). All cases with CMN described in this study were treated with cryocarboxy surgery. In every instance, carbon dioxide has been utilized as the cryogen.
Results
Clinical assessment showed excellent results in 185 (63.4%) patients, good results in 91 (31.2%) patients, and fair results in 16 (5.4%) patients, and no poor results were reported.
Conclusions
Congenital melanocytic nevi of various forms, patients with diverse skin types, and CMNs of various colors, all can be treated with cryocarboxy surgery safely. Cryocarboxy surgery stays away from all the problems with conventional surgery.
Level of evidence: Level IV, therapeutic study.
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Data availability
We confirm that the data supporting the findings of this study are available within the article and at our hospital also.
References
Jahnke M, O’Haver J, Gupta D, Hawryluk E, Finelt N, Kruse L, Jen M, Horii K, Frieden I, Price H, Coughlin C (2021) Care of congenital melanocytic bevi in newborns and infants: review and management recommendations. Pediatrics 148(6):e2021051536. https://doi.org/10.1542/peds.2021-051536
Lyon V (2010) Congenital melanocytic nevi. Pediatr Clin North Am 57(5):1155–1176. https://doi.org/10.1016/j.pcl.2010.07.005
Michel JL (2003) Laser therapy of giant congenital melanocytic nevi. Eur J Dermatol 13(1):57–64
Eggen C, Lommerts J, van Zuuren E, Limpens J, Pasmans S, Wolkerstorfer A (2018) Laser treatment of congenital melanocytic naevi: a systematic review. Br J Dermatol 178(2):369–383. https://doi.org/10.1111/bjd.16094
Marghoob A, Borrego J (2007) Halpern A. Congenital melanocytic nevi: treatment modalities and management options. Semin Cutan Med Surg 26(4):231–40. https://doi.org/10.1016/j.sder.2008.03.007
Tromberg J, Bauer B, Benvenuto-Andrade C, Marghoob AA (2005) Congenital melanocytic nevi treatment. Dermatol Ther 18(2):136–150. https://doi.org/10.1111/j.1529-8019.2005.05012.x
Arneja JS, Gosain AK (2005) Giant congenital melanocytic nevi of the trunk and an algorithm for treatment. J Craniofac Surg 16(5):886–893. https://doi.org/10.1097/01.scs.0000183356.41637.f5
De Raeve L, Roseeuw D (2002) Curettage of giant congenital melanocytic nevi in neonates: a decade later. Arch Dermatol 138(7):943–947. https://doi.org/10.1001/archderm.138.7.943
Omi T, Numano K (2014) The role of the CO2 laser and fractional CO2 laser in dermatology. Laser Ther 27;23(1):49–60. https://doi.org/10.5978/islsm.14-RE-01
August PJ, Ferguson JE, Madan V (2011) A study of the efficacy of carbon dioxide and pigment-specific lasers in the treatment of medium-sized congenital melanocytic naevi. Br J Dermatol 164(5):1037–1042. https://doi.org/10.1111/j.1365-2133.2011.10236.x
Lee JM, Kim IH, Rhyu IJ, Ryu HJ (2015) Combined intense pulsed light and Er: YAG laser treatment of congenital melanocytic nevus. J Cosmet Laser Ther 17(3):162–164. https://doi.org/10.3109/14764172.2014.1003244
Elmelegy N, Elghamry S (2020) Carbon dioxide cryotherapy for treatment of nasal and perinasal congenital melanocytic nevi. Ann Plast Surg 85(2):107–109. https://doi.org/10.1097/SAP.0000000000002145
Krengel S, Scope A, Dusza SW, Vonthein R, Marghoob AA (2013) New recommendations for the categorization of cutaneous features of congenital melanocytic nevi. J Am Acad Dermatol 68(3):441–451. https://doi.org/10.1016/j.jaad.2012.05.043
Kim JY, Jeon JH, Choi TH, Kim BJ (2022) Risk of malignant transformation arising from giant congenital melanocytic nevi: a 20-year single-center study. Dermatol Surg 48(2):171–175. https://doi.org/10.1097/DSS.0000000000003341
Friedman S, Lippitz J (2009) Chemical peels, dermabrasion, and laser therapy. Dis Mon 55(4):223–235. https://doi.org/10.1016/j.disamonth.2008.12.004
Lim JM, Oh Y, Lee SH, Cho MY, Chung KY, Roh MR (2019) Comparison of treatment options for small to medium congenital melanocytic nevi: a retrospective review of 119 cases. Lasers Surg Med 51(1):62–67. https://doi.org/10.1002/lsm.23030
Bray FN, Shah V, Nouri K (2016) Laser treatment of congenital melanocytic nevi: a review of the literature. Lasers Med Sci 31(1):197–204. https://doi.org/10.1007/s10103-015-1833-3
Al-Hadithy N, Al-Nakib K, Quaba A (2012) Outcomes of 52 patients with congenital melanocytic naevi treated with UltraPulse Carbon Dioxide and Frequency Doubled Q-Switched Nd-Yag laser. J Plast Reconstr Aesthet Surg 65(8):1019–1028. https://doi.org/10.1016/j.bjps.2012.03.003
Horner BM, El-Muttardi NS, Mayou BJ (2005) Treatment of congenital melanocytic naevi with CO2 laser. Ann Plast Surg 55(3):276–280. https://doi.org/10.1097/01.sap.0000174365.31469.45
Thai KE, Fergin P, Freeman M, Vinciullo C, Francis D, Spelman L, Murrell D, Anderson C, Weightman W, Reid C, Watson A, Foley P (2004) A prospective study of the use of cryosurgery for the treatment of actinic keratoses. Int J Dermatol 43(9):687–692. https://doi.org/10.1111/j.1365-4632.2004.02056.x
Ashique KT, Kaliyadan F, Jayasree P (2021) Cryotherapy: tips and tricks. J Cutan Aesthet Surg 14(2):244–247. https://doi.org/10.4103/JCAS.JCAS_141_20
Burge SM, Bristol M, Millard PR, Dawber RP (1986) Pigment changes in human skin after cryotherapy. Cryobiology 23(5):422–432. https://doi.org/10.1016/0011-2240(86)90027-1
ALMutairi HM, Al-Hothali GI (2020) The outcome of using different surgical modalities and laser therapy in the treatment of small- and medium-sized congenital melanocytic nevi: a systematic review. Int J Dermatol 59(5):535–542. https://doi.org/10.1111/ijd.14727
Chowchuen B (2011) Long-term outcomes of surgical management in the patients with facial congenital melanocytic nevi. J Med Assoc Thai 94(Suppl 6):S70–S78
Acknowledgements
I acknowledge my colleagues Professor Mostafa Elsonbaty, Assiut University, Professor Abdelnaser Elnagar, Beni Sweif University, Professor Alaa Elsadek, Zagzazeg University, and nursing staff at Tanta University Hospital for their help during all steps of this work.
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No funds were taken from anyone, including the authors, and/or patients. We did not receive any financial or material support or remuneration for the study.
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The author did the study design, performance of surgery, and manuscript preparation.
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All the steps of the procedures performed in this study were following the requirements of the institutional, national research committee, and with the 1964 Helsinki declaration and its later amendments or ethical standards. The rules and principles of ethical and professional conduct have been followed in this study. This article was approved by Tanta University’s Ethical Committee (2011/11/29).
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Informed consent was taken from all patients who participated in the study and additional informed consent was obtained from all individual participants for whom identifying information is included in this article.
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Nader Gomaa Elmelegy declares no conflict of interest..
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Elmelegy, N.G. Cryocarboxy surgery for the aesthetic removal of congenital melanocytic nevi types I, II, and III. Eur J Plast Surg 46, 609–618 (2023). https://doi.org/10.1007/s00238-022-02036-y
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DOI: https://doi.org/10.1007/s00238-022-02036-y