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Non-contrast magnetic resonance venography with Inhance 3D Velocity: diagnostic performance for intracranial venous thrombosis

  • Diagnostic Neuroradiology
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Abstract

Purpose

The aim of this study was to evaluate the diagnostic performance of Inhance 3D Velocity (I3DV) in intracranial venous thrombosis and investigate the possible impact of venous sinus hypoplasia/aplasia on false thrombosis diagnosis made with I3DV.

Methods

This study included 540 patients. Contrast-enhanced magnetic resonance venography combined with conventional sequences was considered the gold standard test (GST), while I3DV was considered as diagnostic test. We accessed the diagnostic success of I3DV for intracranial venous thrombosis detection, thrombosed vessel identification, and total/partial thrombus distinction. The possible relationship between false-positive thrombus diagnosed by I3DV and venous sinus hypoplasia or aplasia diagnosed by GST was investigated.

Results

The sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of I3DV in the detection of intracranial venous thrombosis were 95.7%, 92.1%, 64.1%, 99.3%, and 92.6%, respectively. A significant association was observed between I3DV and GST in terms of thrombosis detection and total/partial thrombus distinction (p < 0.001). A significant relationship was observed between false-positive thrombosis diagnosis in I3DV and hypoplasia in the left transverse sinus (p < 0.001).

Conclusion

Intracranial venous thrombosis may be diagnosed faster and more accurately than traditional phase contrast magnetic resonance angiography in I3DV. This technique can be used in situations where contrast medium application is contraindicated. As in other non-contrast magnetic resonance venography techniques, left transverse sinus hypoplasia can be diagnosed as a thrombosed vessel in I3DV.

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Authors and Affiliations

  1. Department of Radiology, Bursa Uludag University Faculty of Medicine, Bursa, Turkey

    Rifat Ozpar, Mehmet Tonkaz, Duygu Erkal, Gokhan Ongen & Bahattin Hakyemez

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  1. Rifat Ozpar
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  2. Mehmet Tonkaz
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  3. Duygu Erkal
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  4. Gokhan Ongen
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  5. Bahattin Hakyemez
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Contributions

Ozpar R – Data curation, conceptualization

Tonkaz M – Investigation, methodology

Erkal D – Resources, investigation

Ongen G – Resources, data curation

Hakyemez B – Supervision, validation

Corresponding author

Correspondence to Rifat Ozpar.

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The authors declare that they have no conflict of interest

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. The study was approved by the Ethics Committee of Bursa Uludag University Faculty of Medicine.

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Informed consent was obtained from all individual participants included in the study.

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Ozpar, R., Tonkaz, M., Erkal, D. et al. Non-contrast magnetic resonance venography with Inhance 3D Velocity: diagnostic performance for intracranial venous thrombosis. Neuroradiology 63, 1853–1861 (2021). https://doi.org/10.1007/s00234-021-02710-1

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