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Non-invasive assessment of cerebral microvascular changes for predicting postoperative cerebral hyperperfusion after surgical revascularisation for moyamoya disease: an arterial spin labelling MRI study

  • Paediatric Neuroradiology
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Abstract

Purpose

Cerebral hyperperfusion syndrome (CHPS) can result after anastomotic surgery as the reperfusion is established in chronically ischemic cerebral territories in patients of moyamoya disease (MMD). In this study, we have evaluated the feasibility of arterial spin labelling (ASL) perfusion MRI to predict cerebral hyperperfusion syndrome based on changes of cerebral blood flow (CBF) after revascularisation surgery in patients of MMD.

Methods

Our prospective study included 25 patients with MMD who underwent superficial temporal artery-middle cerebral artery (STA-MCA) bypass with or without dural/muscle synangiosis. ASL MRI was performed before and 1–7 days after surgery. On the side planned for operation, 5-mm ROI circle was drawn on the predetermined regions in frontal lobe, temporal lobe, parietal lobe and basal ganglia in proximal and distal territories of MCA to calculate ipsilateral CBF values (CBFi). An attempt was made to select the same location on contralateral side (non-operative) (CBFc) for each measurement for calculation of hemispheric normalised CBF (nCBFh) ratios. To adjust for inter individual variation among MR imagers and CBF, additional regions of interest were drawn within the cerebellum (CBFcbl) for cerebellar CBF normalised ratios (nCBFCbl).

Results

Of the 25 patients (26 operated hemispheres), 5 patients showed significant immediate postoperative symptoms suggestive of CHPS. Based on our findings, sensitivity and specificity of ASL perfusion to detect CHPS were evaluated. ASL was found to have 47–100% sensitivity and 45–88% specificity to detect CHPS. We have tried to calculate the prevalence of CHPS in postoperative patients of moyamoya disease, which in our study ranged from 6.83 to 40.70%.

Conclusion

Based on our results, we concluded that ASL perfusion is an appropriate alternative to standard nuclear medicine studies to monitor the changes in perfusion after STA-MCA bypass surgery in moyamoya patients. ASL MR perfusion can be used to identify changes in cerebral blood flow (CBF) for early detection of cerebral hyperperfusion syndrome in patients with otherwise normal conventional MRI sequences with very high sensitivity but moderate specificity.

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Authors and Affiliations

  1. Neuroradiology Division, Department of Radiodiagnosis and Imaging, Post Graduate institute of Medical Education and Research, Chandigarh, India

    Vivek Agarwal, Paramjeet Singh & Chirag K. Ahuja

  2. Department of Neurosurgery, Post Graduate institute of Medical Education and Research, Chandigarh, India

    Sunil Kumar Gupta, Ashish Aggarwal & Rajashekhar Narayanan

Authors
  1. Vivek Agarwal
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  2. Paramjeet Singh
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  3. Chirag K. Ahuja
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  4. Sunil Kumar Gupta
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  5. Ashish Aggarwal
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  6. Rajashekhar Narayanan
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Contributions

Dr. Vivek Agarwal made a substantial contribution to the concept or design of the work, or acquisition, analysis or interpretation of data; drafted the article or revised it critically for important intellectual content; and approved the version to be published. Dr. Paramjeet Singh made a substantial contribution to the concept or design of the work, or acquisition, analysis or interpretation of data; drafted the article or revised it critically for important intellectual content; and approved the version to be published. Dr. Chirag K Ahuja made a substantial contribution to the concept or design of the work, or acquisition, analysis or interpretation of data, and drafted the article or revised it critically for important intellectual content. Dr. Sunil Kumar Gupta made a substantial contribution to the concept or design of the work, or acquisition, analysis or interpretation of data, and drafted the article or revised it critically for important intellectual content. Dr. Ashish Aggarwal made a substantial contribution to the concept or design of the work, or acquisition, analysis or interpretation of data; drafted the article or revised it critically for important intellectual content; and approved the version to be published. Dr. Rajashekhar Narayanan made a substantial contribution to the concept or design of the work, or acquisition, analysis or interpretation of data, and drafted the article or revised it critically for important intellectual content.

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Correspondence to Vivek Agarwal.

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All procedures performed in the studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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Agarwal, V., Singh, P., Ahuja, C.K. et al. Non-invasive assessment of cerebral microvascular changes for predicting postoperative cerebral hyperperfusion after surgical revascularisation for moyamoya disease: an arterial spin labelling MRI study. Neuroradiology 63, 563–572 (2021). https://doi.org/10.1007/s00234-020-02583-w

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  • DOI: https://doi.org/10.1007/s00234-020-02583-w

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