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Potential usefulness of signal intensity of cerebral gyri on quantitative susceptibility mapping for discriminating corticobasal degeneration from progressive supranuclear palsy and Parkinson’s disease

  • Diagnostic Neuroradiology
  • Published:
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Abstract

Purpose

The typical MRI findings in corticobasal degeneration (CBD), which have been described in previous reports, may be non-specific. We evaluated cerebral gyri (CG) using quantitative susceptibility mapping (QSM) images of patients with CBD, progressive supranuclear palsy (PSP), and Parkinson’s disease (PD) to determine the possibility of discriminating them on an individual basis.

Methods

After reviewing the normal appearances on QSM on 16 healthy subjects, two radiologists assessed abnormal findings from 12 CBD, 14 PSP, and 30 PD patients. For conventional MRI, two radiologists independently reviewed typical CBD findings that have been previously reported. We also investigated three autopsy cases including one each of CBD, PSP, and PD to reveal the histopathological basis of MRI findings.

Results

CBD-specific findings included three layers; a higher susceptibility layer in superficial GM, a lower susceptibility layer, and a higher susceptibility layer in corticomedullary junction, with frequencies of 83% (10/12) in CBD, 21% (3/14) in PSP, and 0% (0/30) in PD patients. The typical CBD findings on conventional MRI were observed in only 42% (5/12) of CBD patients. Ferritin-positive microglia accumulated in the superficial gray matter (third cortical layer) and corticomedullary junction in CBD patients.

Conclusions

The CG findings on QSM images may be more useful than those on conventional MRI for discriminating CBD from PD on an individual basis. Based on postmortem pathological data, cortical QSM hyperintensity might be an expression of ferritin-positive microglia.

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Abbreviations

CBD:

Corticobasal degeneration

CG:

Cerebral gyri

GM:

Gray matter

PD:

Parkinson’s disease

PSP:

Progressive supranuclear palsy

QSM:

Quantitative susceptibility mapping

WM:

White matter

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Funding

No funding was received for this study.

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Authors and Affiliations

  1. Department of Radiology, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu, Fukuoka, 807-8555, Japan

    Mari Miyata, Shingo Kakeda, Satoru Ide & Yukunori Korogi

  2. Department of Pathology, Brain Research Institute, Niigata University, Niigata, Japan

    Yasuko Toyoshima

  3. Department of Neurology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Fukuoka, Japan

    Kazumasa Okada & Hiroaki Adachi

  4. Department of Biomedical Engineering, Cornell University, Ithaca, NY, USA

    Yi Wang

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  1. Mari Miyata
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  2. Shingo Kakeda
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Correspondence to Mari Miyata.

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The authors have no conflicts of interest directly relevant to the content of this article.

Ethical approval

All procedures performed in the studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

Informed consent

Human experiments were performed in accordance with the guidelines provided and approved by the Institutional Review Board of the University of Occupational and Environmental Health School of Medicine (Kitakyushu, Fukuoka, Japan). Our institutional review board approved this retrospective study, which analyzed existing, de-identified patient data, and waived informed consent.

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Miyata, M., Kakeda, S., Toyoshima, Y. et al. Potential usefulness of signal intensity of cerebral gyri on quantitative susceptibility mapping for discriminating corticobasal degeneration from progressive supranuclear palsy and Parkinson’s disease. Neuroradiology 61, 1251–1259 (2019). https://doi.org/10.1007/s00234-019-02253-6

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  • DOI: https://doi.org/10.1007/s00234-019-02253-6

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