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Evaluation of multiparametric MRI differentiating sinonasal angiomatous polyp from malignant tumors

  • Head-Neck-ENT Radiology
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Abstract

Purpose

Sinonasal angiomatous polyps (SAPs) can be misdiagnosed as malignant tumors due to aggressive clinical behaviors. The purpose of this study was to evaluate the diagnostic accuracy of multiparametric MRI in differentiating SAPs from malignant tumors.

Methods

This retrospective study included 31 patients with pathologically proven SAPs and 36 patients with malignant tumors in maxillary sinus and nasal cavity. All the patients underwent conventional MRI and dynamic contrast-enhanced (DCE) MRI on 3T MR scanners. Diffusion-weighted (DW) MR imaging was performed in 45 patients. All the MR images were retrospectively analyzed independently by two authors.

Results

Significant differences were found in T1 homogeneity, T2 signal intensity ratio, peripheral hypointense rim on T2WI, and soft tissue infiltration between SAP and malignant tumors (P = 0.004, < 0.001, < 0.001, and = 0.001, respectively). SAPs usually show heterogeneous signal intensity on T1WI, peripheral hypointense rim on T2WI, and higher T2 signal intensity ratio. The tumor size of SAP (4.01 ± 1.08 cm) was slightly smaller than that of malignant tumors (4.56 ± 1.12 cm) (P = 0.045). There were significant differences in DCE-MRI parameters including Tpeak, CImax, WR, TIC types, and progressive enhancement (P = 0.009, < 0.001, = 0.001, = 0.001, and < 0.001, respectively) between SAPs and malignant tumors. All the 31 SAPs showed progressive enhancement on DCE-MRI, while none of the malignant tumors showed progressive enhancement (accuracy 100%). The mean ADC of SAP (1.75 ± 0.30 × 10−3 mm2/s) was higher than that of malignant tumors (1.18 ± 0.31 × 10−3 mm2/s) (P < 0.001).

Conclusion

Multiparametric MRI showed high diagnostic performance in differentiating SAPs from malignant tumors. Progressive enhancement on DCE-MRI is the most effective feature of SAP.

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Funding

High Level Health Technical Personnel of Bureau of Health in Beijing (2014-2-005); Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support (ZYLX201704); National Key Technology Research and Development Program of the Ministry of Science and Technology of China (2015BAll6H00); “Key Talent Project” of Beijing (2014001); “Set Sail Project” of Fujian Medical University (2017XQ1016).

Author information

Author notes

  1. XW and YL contributed equally to this study.

Authors and Affiliations

  1. Department of Radiology, Beijing Tongren Hospital, Capital Medical University, Beijing, 100730, China

    Xinyan Wang, Qinghua Chen & Junfang Xian

  2. Department of Radiology, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, China

    Ying Liu

  3. Department of Medical Imaging Technology, College of Medical Technology and Engineering, Fujian Medical University, Fuzhou, Fujian, China

    Ying Liu

Authors
  1. Xinyan Wang
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  2. Ying Liu
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  3. Qinghua Chen
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  4. Junfang Xian
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Corresponding author

Correspondence to Junfang Xian.

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The authors declare that they have no conflict of interest.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. For this type of study formal consent is not required.

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For this type of retrospective study formal consent is not required.

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Wang, X., Liu, Y., Chen, Q. et al. Evaluation of multiparametric MRI differentiating sinonasal angiomatous polyp from malignant tumors. Neuroradiology 61, 891–896 (2019). https://doi.org/10.1007/s00234-019-02225-w

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  • DOI: https://doi.org/10.1007/s00234-019-02225-w

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