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Quantitative sodium imaging and gliomas: a feasibility study

  • Diagnostic Neuroradiology
  • Published:
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Abstract

Purpose

Recent advances in sodium brain MRI have allowed for increased signal-to-noise ratio, faster imaging, and the ability of differentiating intracellular from extracellular sodium concentration, opening a new window of opportunity for clinical application. In gliomas, there are significant alterations in sodium metabolism, including increase in the total sodium concentration and extracellular volume fraction. The purpose of this study is to assess the feasibility of using sodium MRI quantitative measurements to evaluate gliomas.

Methods

Eight patients with treatment-naïve gliomas were scanned at 3 T with a homemade 1H/23Na head coil, generating maps of pseudo-intracellular sodium concentration (C1), pseudo-extracellular volume fraction (α2), apparent intracellular sodium concentration (aISC), and apparent total sodium concentration (aTSC). Measurements were made within the contralateral normal-appearing putamen, contralateral normal-appearing white matter (NAWM), and solid tumor regions (area of T2-FLAIR abnormality, excluding highly likely areas of edema, cysts, or necrosis). Paired samples t test were performed comparing NAWM and putamen and between NAWM and solid tumor.

Results

The normal-appearing putamen demonstrated significantly higher values for aTSC, aISC, C1 (p < 0.001), and α2 (p = 0.002) when compared to those of NAWM. The mean average of all solid tumors, when compared to that of NAWM, demonstrated significantly higher values of aTSC and α2 (p < 0.001), and significantly lower values of aISC (p = 0.02) for each patient. There was no significant difference between the values of C1 (p = 0.19).

Conclusion

Quantitative sodium measurements can be done in glioma patients and also has provided further evidence that total sodium and extracellular volume fraction are increased in gliomas.

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Authors and Affiliations

  1. Department of Radiology, New York University School of Medicine, 660 1st Avenue, New York, 10016, NY, USA

    Lucidio P. Nunes Neto, Guillaume Madelin, Terlika Pandit Sood, Chih-Chun Wu & Rajan Jain

  2. Department of Neurosurgery, New York University School of Medicine, 660 1st Avenue, New York, 10016, NY, USA

    Douglas Kondziolka, Dimitris Placantonakis, John G. Golfinos & Rajan Jain

  3. Department of Medicine, New York University School of Medicine, 660 1st Avenue, New York, 10016, NY, USA

    Andrew Chi

Authors
  1. Lucidio P. Nunes Neto
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  2. Guillaume Madelin
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  3. Terlika Pandit Sood
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  4. Chih-Chun Wu
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  5. Douglas Kondziolka
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  6. Dimitris Placantonakis
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  7. John G. Golfinos
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  8. Andrew Chi
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  9. Rajan Jain
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Corresponding author

Correspondence to Rajan Jain.

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Funding

This study was funded in part by the National Institutes of Health (NIH): 1R03AR065763 (GM), 1R01NS097494 (GM) and 1R21CA213169 (GM), and the NIBIB for the P41 (CAI2R), a NIBIB Biomedical Technology Resource Center (NIH: 1P41EB017183) program grant.

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in the studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

Additional information

This study was presented as an oral presentation at the American Society of Neuroradiology (ASNR) 55th Annual Meeting, April 24–27, 2017, Long Beach, CA, USA.

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Nunes Neto, L.P., Madelin, G., Sood, T.P. et al. Quantitative sodium imaging and gliomas: a feasibility study. Neuroradiology 60, 795–802 (2018). https://doi.org/10.1007/s00234-018-2041-1

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  • DOI: https://doi.org/10.1007/s00234-018-2041-1

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