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Comparative study of pulsed-continuous arterial spin labeling and dynamic susceptibility contrast imaging by histogram analysis in evaluation of glial tumors

  • Diagnostic Neuroradiology
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Abstract

Purpose

Arterial spin labeling (ASL) is a non-invasive perfusion technique that may be an alternative to dynamic susceptibility contrast magnetic resonance imaging (DSC-MRI) for assessment of brain tumors. To our knowledge, there have been no reports on histogram analysis of ASL. The purpose of this study was to determine whether ASL is comparable with DSC-MRI in terms of differentiating high-grade and low-grade gliomas by evaluating the histogram analysis of cerebral blood flow (CBF) in the entire tumor.

Methods

Thirty-four patients with pathologically proven glioma underwent ASL and DSC-MRI. High-signal areas on contrast-enhanced T1-weighted images or high-intensity areas on fluid-attenuated inversion recovery images were designated as the volumes of interest (VOIs). ASL-CBF, DSC-CBF, and DSC-cerebral blood volume maps were constructed and co-registered to the VOI. Perfusion histogram analyses of the whole VOI and statistical analyses were performed to compare the ASL and DSC images.

Results

There was no significant difference in the mean values for any of the histogram metrics in both of the low-grade gliomas (n = 15) and the high-grade gliomas (n = 19). Strong correlations were seen in the 75th percentile, mean, median, and standard deviation values between the ASL and DSC images. The area under the curve values tended to be greater for the DSC images than for the ASL images.

Conclusions

DSC-MRI is superior to ASL for distinguishing high-grade from low-grade glioma. ASL could be an alternative evaluation method when DSC-MRI cannot be used, e.g., in patients with renal failure, those in whom repeated examination is required, and in children.

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Authors and Affiliations

  1. Department of Diagnostic and Interventional Radiology, Osaka University Graduate School of Medicine, 2-2, Yamadaoka, Suita, Osaka, 565-0871, Japan

    Atsuko Arisawa, Yoshiyuki Watanabe, Hisashi Tanaka, Hiroto Takahashi, Chisato Matsuo, Takuya Fujiwara, Masahiro Fujiwara & Noriyuki Tomiyama

  2. Department of Neurosurgery, Osaka University Graduate School of Medicine, Osaka, Japan

    Yasunori Fujimoto

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  1. Atsuko Arisawa
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  2. Yoshiyuki Watanabe
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  3. Hisashi Tanaka
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  4. Hiroto Takahashi
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Correspondence to Yoshiyuki Watanabe.

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Arisawa, A., Watanabe, Y., Tanaka, H. et al. Comparative study of pulsed-continuous arterial spin labeling and dynamic susceptibility contrast imaging by histogram analysis in evaluation of glial tumors. Neuroradiology 60, 599–608 (2018). https://doi.org/10.1007/s00234-018-2024-2

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