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Recurrent stenosis following carotid artery stenting treated with a drug-eluting balloon: a single-center retrospective analysis

  • Interventional Neuroradiology
  • Published:
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Abstract

Purpose

Early in-stent restenosis after stent-protected angioplasty of the carotid artery (SPAC) is an infrequent, but potentially harmful condition for patients with carotid artery disease.

Methods

In our retrospective single-center analysis of 176 patients with carotid artery stenting between 2009 and 2015, using duplex ultrasound, we detected 9 patients with high-grade carotid artery in-stent restenosis. All restenosis patients were treated with a drug-eluting balloon (DEB) to prevent recurrent neointimal hyperplasia. One patient had bilateral carotid artery disease with bilateral in-stent restenosis, and 1 patient needed repeated DEB treatment 19 months after the first DEB intervention, so 11 DEB procedures, in total, were performed.

Results

The median time-interval between primary carotid artery stenting and first DEB-treatment was 9 months. In 3 of the 11 interventions, the DEB treatment was assisted by an additional stent. One repeat DEB treatment was necessary, and three DEB treatments were followed by a secondary stent. No peri-interventional complications (TIA, stroke, or death) were observed during or after DEB intervention. Therefore, in the entire group, the 1y event-free survival (EFS) was 100%, and the 2y/3y/5y EFS was 83%.

Conclusion

DEB intervention seems to be an effective and safe treatment for patients with high-grade in-stent restenosis after SPAC.

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Authors and Affiliations

  1. Abteilung für Neurologie, Asklepios Klinik Barmbek, 22291, Hamburg, Germany

    C. Pohlmann & P. P. Urban

  2. Radiologie und Neuroradiologie, Asklepios Klinik Wandsbek, 22043, Hamburg, Germany

    J. Höltje

  3. Asklepios Klinik Barmbek, Radiology and Neuroradiology, Rübenkamp 220, D-22291, Hamburg, Germany

    M. Zeile, F. Bonk & R. Brüning

Authors
  1. C. Pohlmann
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  2. J. Höltje
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  3. M. Zeile
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  4. F. Bonk
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  5. P. P. Urban
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  6. R. Brüning
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Corresponding author

Correspondence to R. Brüning.

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No funding was received for this study.

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The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in the studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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Pohlmann, C., Höltje, J., Zeile, M. et al. Recurrent stenosis following carotid artery stenting treated with a drug-eluting balloon: a single-center retrospective analysis. Neuroradiology 60, 81–87 (2018). https://doi.org/10.1007/s00234-017-1935-7

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  • DOI: https://doi.org/10.1007/s00234-017-1935-7

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