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Enhanced Drug Uptake on Application of Electroporation in a Single-Cell Model

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Abstract

Electroporation method is a useful tool for delivering drugs into various diseased tissues in the human body. As a result of an applied electric field, drug particles enter the intracellular compartment through the temporarily permeabilized cell membrane. Consequently, electroporation method allows better penetration of the drug into the diseased tissue and improves treatment clinically. In this study, a more generalized model of drug transport in a single cell is proposed. The model is able to capture non-homogeneous drug transport in the cell due to non-uniform cell membrane permeabilization. Several numerical experiments are conducted to understand the effects of electric field and drug permeability on drug uptake into the cell. Through investigation, the appropriate electric field and drug permeability are identified, which lead to sufficient drug uptake into the cell. This model can be used by experimentalists to get information prior to conduct any experiment, and it may help reduce the number of actual experiments that might be conducted otherwise.

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Data Availability

The authors declare that the results/data/figures in this manuscript have not been published elsewhere, nor are they under consideration by another publisher. The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.

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Funding

The authors declare that no funds, grants, or other support were received during the preparation of this manuscript.

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Author notes

  1. Nilay Mondal, K. S. Yadav and D. C. Dalal have contributed equally to this work.

Authors and Affiliations

  1. Faculty of Science and Technology, ICFAI University, Kamalghat, Agartala, Tripura, 799210, India

    Nilay Mondal

  2. Faculty of Engineering & Technology, Siksha ‘O’ Anusandhan (Deemed to be University), Bhubaneswar, Odisha, 751030, India

    K. S. Yadav

  3. Department of Mathematics, Indian Institute of Technology Guwahati, Amingaon, Guwahati, Assam, 781039, India

    D. C. Dalal

Authors
  1. Nilay Mondal
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  2. K. S. Yadav
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  3. D. C. Dalal
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Correspondence to K. S. Yadav.

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Mondal, N., Yadav, K.S. & Dalal, D.C. Enhanced Drug Uptake on Application of Electroporation in a Single-Cell Model. J Membrane Biol 256, 243–255 (2023). https://doi.org/10.1007/s00232-023-00283-z

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  • DOI: https://doi.org/10.1007/s00232-023-00283-z

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