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Membrane Dynamics and Remodelling in Response to the Action of the Membrane-Damaging Pore-Forming Toxins

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Abstract

Pore-forming protein toxins (PFTs) represent a diverse class of membrane-damaging proteins that are produced by a wide variety of organisms. PFT-mediated membrane perforation is largely governed by the chemical composition and the physical properties of the plasma membranes. The interaction between the PFTs with the target membranes is critical for the initiation of the pore-formation process, and can lead to discrete membrane reorganization events that further aids in the process of pore-formation. Punching holes on the plasma membranes by the PFTs interferes with the cellular homeostasis by disrupting the ion-balance inside the cells that in turn can turn on multiple signalling cascades required to restore membrane integrity and cellular homeostasis. In this review, we discuss the physicochemical attributes of the plasma membranes associated with the pore-formation processes by the PFTs, and the subsequent membrane remodelling events that may start off the membrane-repair mechanisms.

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Acknowledgements

Authors acknowledge Indian Institute of Science Education and Research Mohali for fund support. Authors also acknowledge support from Council of Scientific and Industrial Research (CSIR), India (for research fellowship to K.L.), Department of Biotechnology (DBT), Government of India (for research fellowship to M.S.), and University Grants Commission (UGC), India (for research fellowship to S.C.).

Funding

This study was supported by Indian Institute of Science Education and Research Mohali.

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Author notes

  1. Kusum Lata, Mahendra Singh, and Shamaita Chatterjee have contributed equally to this manuscript.

Authors and Affiliations

  1. Department of Biological Sciences, Indian Institute of Science Education and Research Mohali, Sector 81, SAS Nagar, Manauli, Mohali, Punjab, 140306, India

    Kusum Lata, Mahendra Singh, Shamaita Chatterjee & Kausik Chattopadhyay

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  1. Kusum Lata
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  2. Mahendra Singh
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  3. Shamaita Chatterjee
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  4. Kausik Chattopadhyay
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Correspondence to Kausik Chattopadhyay.

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Lata, K., Singh, M., Chatterjee, S. et al. Membrane Dynamics and Remodelling in Response to the Action of the Membrane-Damaging Pore-Forming Toxins. J Membrane Biol 255, 161–173 (2022). https://doi.org/10.1007/s00232-022-00227-z

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