Abstract
OxlT, the oxalate transporter of Oxalobacter formigenes, is a member of the Major Facilitator Superfamily of transporters (MFS), one of the largest groups of membrane proteins with substantial relevance to solute transport physiology, pharmacology, and possible drug development. MFS proteins transport a wide range of substrates such as organic and inorganic anions, sugars, drugs, and neurotransmitters. This review succinctly summarizes experimental work on a model MFS protein, OxlT, beginning with its identification as an electrogenic oxalate/formate exchanger, its three-dimensional structure, and discussion of biochemical and biophysical data that have shed further light on its structure and function. We also discuss the structure and function of OxlT in relation to notable MFS carriers such as LacY and GlpT.
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Acknowledgments
The authors are grateful for support provided by the Department of Physiology, The Johns Hopkins University School of Medicine and National Institutes of Health R01 GM024195 (to Dr. Peter C. Maloney).
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All authors (OI, CMK, DCK) declare no conflict of interest.
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Iyalomhe, O., Khantwal, C.M. & Kang, D.C. The Structure and Function of OxlT, the Oxalate Transporter of Oxalobacter formigenes . J Membrane Biol 248, 641–650 (2015). https://doi.org/10.1007/s00232-014-9728-y
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DOI: https://doi.org/10.1007/s00232-014-9728-y