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STOPPFrail (Screening Tool of Older Persons’ Prescriptions in Frail adults with a limited life expectancy) criteria: application to a representative population awaiting long-term nursing care

  • Pharmacoepidemiology and Prescription
  • Published:
European Journal of Clinical Pharmacology Aims and scope Submit manuscript

Abstract

Purpose

STOPPFrail criteria highlight instances of potentially inappropriate medications (PIMs) in frailer older adults with poor 1-year survival prognosis. The objectives of this study were to (i) determine the proportion of older adults requiring long-term nursing care in whom STOPPFrail criteria are applicable, (ii) measure the prevalence of STOPPFrail PIMs, and (iii) identify risk factors for PIMs in this cohort.

Methods

We retrospectively reviewed applications for long-term nursing care to nursing homes in the Cork area over a 6-month period. We recorded diagnoses, medications, functional status, cognitive ability, frailty status, and applied STOPPFrail criteria as appropriate.

Results

We reviewed 464 applications; 38 were excluded due to incomplete information and 274 patients (64.3%) met STOPPFrail eligibility criteria (median age 83 years (IQR 77.25–88); 233 (54.7%) female). Those STOPPFrail eligible were prescribed 2194 medications (mean 8, (SD 4)), of which 828 (37.7%) were PIMs. At least one PIM was identified in 250 eligible patients (91.2%). The median number of PIMs was 3 (IQR 2–4), the most common being (i) medications without clear indication identified in 47.0% (n = 129) of patients, (ii) long-term high-dose proton pump inhibitors in 31.4% (n = 86), and (iii) statins in 29.6% (n = 81). For every additional medication prescribed, the odds of identifying a PIM increased by 58% (odds ratio 1.58, 95% CI 1.32–1.89, p < 0.001).

Conclusion

Almost 65% of patients awaiting long-term care are eligible for the application of STOPPFrail criteria with over 90% prescribed at least one PIM. Transition to nursing home care represents an opportunity to review therapeutic appropriateness and goals of prescribed medications.

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Funding

This research has been funded as part of the SENATOR project funded by the European Union’s Seventh Framework Program (EU FP7) programme (grant number 305930). Health Research Board Clinical Research Facility at University College Cork (HRB CRF-C).

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Authors and Affiliations

  1. Department of Medicine (Geriatrics), University College Cork, Cork University Hospital, Wilton, Cork, T12 DC4A, Ireland

    Amanda Hanora Lavan, Denis O’Mahony & Paul Gallagher

  2. Department of Geriatric Medicine, Cork University Hospital, Cork, Ireland

    Amanda Hanora Lavan, Denis O’Mahony & Paul Gallagher

Authors
  1. Amanda Hanora Lavan
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  2. Denis O’Mahony
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  3. Paul Gallagher
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Corresponding author

Correspondence to Amanda Hanora Lavan.

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The local Clinical Research Ethics Committee at University College Cork (UCC) approved the study protocol.

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The authors declare that they have no conflict of interest.

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Lavan, A.H., O’Mahony, D. & Gallagher, P. STOPPFrail (Screening Tool of Older Persons’ Prescriptions in Frail adults with a limited life expectancy) criteria: application to a representative population awaiting long-term nursing care. Eur J Clin Pharmacol 75, 723–731 (2019). https://doi.org/10.1007/s00228-019-02630-3

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  • DOI: https://doi.org/10.1007/s00228-019-02630-3

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