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Reference Values of Total Lean Mass, Appendicular Lean Mass, and Fat Mass Measured with Dual-Energy X-ray Absorptiometry in a Healthy Mexican Population

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An Erratum to this article was published on 10 November 2016

Abstract

The aim of this study was to develop age- and gender-specific reference values of total lean body mass (LBM), appendicular lean body mass (ALBM), and fat mass (FM) by dual-energy X-ray absorptiometry (DXA) data in a healthy Mexican population. A cross-sectional analysis was conducted on 9518 healthy subjects 7–89 years of age participating in the baseline measurement of the Health Workers Cohort Study. Using DXA, LBM, ALBM, and FM were measured. Using these data, LBM index (LBMI), ALBM index (ALBMI), and fat mass index (FMI) were calculated. LMI, ALMI, and FMI were calculated as the LBM, ALBM, and FM kg divided by the height in meters squared. Males and females were analyzed separately; sex-specific means and standard deviations for LBM, ALBM, FM, LBMI, ALBMI, and FMI were calculated. A total of 2829 males and 6694 females were included in the final analysis. Strong sex gaps were observed after 12 years in LBM, ALBM, LBMI, and ALBMI (P < 0.01). LBM and ALBM values continue to increase for males up to age 20; females plateaued approximately after age 15. Significant sex differences were also observed for FM and FMI. Significant sex- and age-related differences exist in LBM, ALBM, and FM in the Mexican population. In addition, given the null data available in this area, these reference values may be useful in the evaluation of a variety of childhood and adult abnormalities involving lean body mass deficits, mainly in the assessment of muscle wasting, with important medical and epidemiological uses.

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References

  1. Ling CH, Craen AJ, Slagboom PE, Gunn DA, Stokkel MP, Westendorp RG, Maier AB (2011) Accuracy of direct segmental multi-frequency bioimpedance analysis in the assessment of total body and segmental body composition in middle-aged adult population. Clin Nutr 30(5):610–615

    Article  PubMed  Google Scholar 

  2. Cooper C, Westlake S, Harvey N, Javaid K, Dennison E (2006) Review: developmental origins of osteoporotic fractures. Osteoporos Int 17:337–347

    Article  PubMed  Google Scholar 

  3. Gillette-Guyonnet S, Vellas B (2003) Body composition and age-related diseases. Mech Ageing Dev 124:247–248

    Article  CAS  PubMed  Google Scholar 

  4. Lee RC, Wang ZM, Heymsfield SB (2001) Skeletal muscle mass and aging: regional and whole body measurement methods. Can J Appl Physiol 26:102–122

    Article  CAS  PubMed  Google Scholar 

  5. Blake GM, Naeem M, Boutros M (2006) Comparison of effective dose to children and adult from dual X-ray absorptiometry examinations. Bone 38:935–942

    Article  PubMed  Google Scholar 

  6. Mazess RB, Barden HS, Bisek JP, Hanson J (1990) Dual energy X-ray absorptiometry for total-body and regional bone-mineral and soft-tissue composition. Am J Clin Nutr 51:1106–1112

    CAS  PubMed  Google Scholar 

  7. Brunton JA, Bayley HS, Atkinson SA (1993) Validation and application of dual energy X-ray absorptiometry to measure bone mass and body composition in small infants. Am J Clin Nutr 58:839–845

    CAS  PubMed  Google Scholar 

  8. Guo B, Gong J, Tang Y, Shang J, Xu H (2015) Reference data and percentile curves of body composition measured with dual energy X-ray absorptiometry in healthy Chinese children and adolescents. J Bone Miner Metab 33(5):530–539

    Article  PubMed  Google Scholar 

  9. Gould H, Brennan SL, Kotowicz MA, Nicholson GC, Pasco JA (2014) Total and appendicular lean mass reference for Australian men and women: the Geelong osteoporosis study. Calcif Tiss Int 94:363–372

    Article  CAS  Google Scholar 

  10. Kelly TL, Wilson KE, Heymsfield SB (2009) Dual energy X-ray absorptiometry body composition reference values from NHANES. PLoS ONE 4(9):e7038. doi:10.1371/journal.pone.0007038

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Nakavachara P, Pooliam J, Weerakulwattana L et al (2014) A normal reference of bone mineral density (BMD) measured by dual energy X-ray absorptiometry in healthy Thai children and adolescents aged 5–18 years: a new reference for Southeast Asian populations. PLoS ONE 9(5):e97218. doi:10.1371/journal.pone.0097218

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Denova-Gutierrez E, Castañon S, Talavera JO et al (2010) Dietary patterns are associated with metabolic syndrome in an urban Mexican population. J Nutr 140:1855–1863

    Article  CAS  PubMed  Google Scholar 

  13. Denova-Gutiérrez E, Castañón S, Talavera JO et al (2011) Dietary patterns are associated with different indexes of adiposity and obesity in an urban Mexican population. J Nutr 141(5):921–927

    Article  CAS  PubMed  Google Scholar 

  14. Leib ES, Lewiecki EM, Binkley N, Hamdy RC, International Society for Clinical Densitometry (2004) Official positions of the International Society for Clinical Densitometry. J Clin Densitom 7(1):1–6

  15. Baumgartner RN (1998) Epidemiology of sarcopenia among the elderly in New Mexico. Am J Epidemiol 147(8):755–763

    Article  CAS  PubMed  Google Scholar 

  16. Schutz Y, Kyle UU, Pichard C (2002) Fat-free mass index and fat mass index percentiles in Caucasians aged 18–98 y. Int J Obes Relat Metab Disord 26(7):953–960

    Article  CAS  PubMed  Google Scholar 

  17. Martin LG, Grossman MS, Connor TB, Levitsky LL, Clark JW, Camitta FD (1979) Effect of androgen on growth hormone secretion and growth in boys with short stature. Acta Endocrinol 91(2):201–212

    CAS  PubMed  Google Scholar 

  18. Boot AM, Bouquet J, de Ridder MA, Krenning EP, de Muinck Keizer-Schrama SM (1997) Determinants of body composition measurements by dual-energy X-ray absorptiometry in Dutch children and adolescents. Am J Clin Nutr 66:232–238

    CAS  PubMed  Google Scholar 

  19. Weber DR, Moore RH, Leonard MB, Zemek BS (2013) Fat and lean BMI reference curves in children and adolescents and their utility in identifying excess adiposity comparing with BMI and percentage body fat. Am J Clin Nutr 98:49–56

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  20. Kim K, Yun SH, Jang MJ, Oh KW (2013) Body fat percentile curves for Korean children and adolescents: a data from Korea national health and nutrition examination survey 2009–2010. J Korean Med Sci 28:443–449

    Article  PubMed  PubMed Central  Google Scholar 

  21. Frisch RE, Revelle R (1970) Height and weight at menarche and a hypothesis of critical body weights and adolescent events. Science 169:397–399

    Article  CAS  PubMed  Google Scholar 

  22. Frisch RE (1987) Body fat, menarche, fitness and fertility. Hum Reprod 2:521–533

    CAS  PubMed  Google Scholar 

  23. Heymsfield SB, Gallagher D, Mayer L, Beetsch J, Pietrobelli (2007) Scaling of human body composition to stature: new insights into body mass index. Am J Clin Nutr 86:82–91

    CAS  PubMed  PubMed Central  Google Scholar 

  24. Eissa MA, Dai S, Mihalopoulos NL, Day RS, Harrist RB, Labarthe DR (2009) Trajectories of fat mass index, fat-free mass index, and waist circumference in children: project heart beat. Am J Prev Med 37:S34–S39

    Article  PubMed  PubMed Central  Google Scholar 

  25. Hull HR, Thornton J, Wang J et al (2011) Fat-free mass index: changes and race/ethnic differences in adulthood. Int J Obes 35:121–127

    Article  CAS  Google Scholar 

  26. Seino S, Shinkai S, Iijima K et al (2015) Reference values and age differences in body composition of community-dwelling older Japanese men and women: a pooled analysis of four cohort studies. PLoS ONE 10(7):e0131975. doi:10.1371/journal.pone.0131975

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  27. Ellis KJ (1997) Body composition of a young, multiethnic, male population. Am J Clin Nutr 65:724–731

    CAS  PubMed  Google Scholar 

  28. Nelson DA, Barondess DA (1997) Whole body bone, fat and lean mass in children: comparison of three ethnic groups. Am J Phys Anthropol 103:157–162

    Article  CAS  PubMed  Google Scholar 

  29. Ellis KJ (1997) Body composition of a young, multiethnic, female population. Am J Clin Nutr 66:1323–1331

    CAS  PubMed  Google Scholar 

  30. Karlsson MK, Gärdsell P, Johnell O, Nilsson BE, Akesson K, Obrant KJ (1993) Bone mineral normative data in Malmö, Sweden. Comparison with reference data and hip fracture incidence in other ethnic groups. Acta Orthop Scand 64(2):168–172

    Article  CAS  PubMed  Google Scholar 

  31. Andreoli A, Bazzocchi A, Celi M, Lauro D, Sorge R, Tarantino U, Guglielmi G (2011) Relationship between body composition, body mass index and bone mineral density in a large population of normal, osteopenic and osteoporotic women. Radiol Med 116(7):1115–1123

    Article  CAS  PubMed  Google Scholar 

  32. Berne RM, Levy MN (1998) Physiology, 4th edn. Mosby, St. Louis

    Google Scholar 

  33. Harman SM, Metter EJ, Tobin JD, Pearson J, Blackman MR (2001) Longitudinal effects of aging on serum total and free testosterone levels in healthy men. Baltimore Longitudinal Study of Aging. J Clin Endocrinol Metabol 86:724–731

    Article  CAS  Google Scholar 

  34. Melton LJ 3rd, Khosla S Crowson CS, O’Connor MK, O’Fallon WM, Riggs BL (2000) Epidemiology of sarcopenia. J Am Geriatr Soc 48(6):625–630

  35. Gallagher D, Rust E, Visser M et al (2000) Weight stability masks sarcopenia in elderly men and women. Am J Physiol Endocrinol Metabol 279(2):E366–E375

    CAS  Google Scholar 

  36. Iannuzzi-Sucich M, Prestwood KM, Kenny AM (2002) Prevalence of sarcopenia and predictors of skeletal muscle mass in healthy, older men and women. J Gerontol A Biol Sci Med Sci 57(12):M772–M777

    Article  PubMed  Google Scholar 

  37. Janssen I, Heymsfield SB, Wang Z, Ross R (2000) Skeletal muscle mass and distribution in 468 men and women aged 18–99 yr. J Appl Physiol 89:81–88

    CAS  PubMed  Google Scholar 

  38. Tothil P, Avennell A, Love J, Reid DM (1994) Comparisons between hologic, lunar and norland dual-energy X-ray absorptiometers and other techniques used for whole-body soft tissue measurements. Eur J Clin Nutr 48:781–794

    Google Scholar 

  39. Laskey MA, Prentice A (1999) Comparison of adult and pediatric spine and whole body software for the lunar dual energy X-ray absorptiometry. Br J Radiol 72:967–976

    Article  CAS  PubMed  Google Scholar 

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Acknowledgments

The original study was supported by Consejo Nacional de Ciencia y Tecnología (Grants 87783, and 7876) Mexico City.

Contributors

The authors’ responsibilities were as follows: Author #6 designed the study and secured funding; author #1, author #2, and author #3 conducted the research; author #2, author #4, and author #5 performed the statistical analyses; author #1 and author #2 wrote the manuscript; author #1, author #2, and author #6 critically reviewed the manuscript. All authors reviewed and commented on the manuscript. All authors read and approved the final version of the paper.

Author information

Authors and Affiliations

  1. Unidad de Investigación en Epidemiología Clínica, Hospital Infantil de México Federico Gómez, Ciudad de México, Mexico

    Patricia Clark, Edgar Denova-Gutiérrez & Regina Ambrosi

  2. INSERM UMR, University of Lyon, Lyon, France

    Pawel Szulc

  3. Centro Médico Nacional SIGLO XXI, Instituto Mexicano del Seguro Social, Ciudad de México, Mexico

    Rodolfo Rivas-Ruiz

  4. Unidad de Investigación Epidemiológica y en Servicios de Salud, Instituto Mexicano del Seguro Social, Cuernavaca, Mexico

    Jorge Salmerón

  5. Centro de Investigación en Salud Poblacional, Instituto Nacional de Salud Pública, Cuernavaca, Mexico

    Jorge Salmerón

Authors
  1. Patricia Clark
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  2. Edgar Denova-Gutiérrez
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  3. Regina Ambrosi
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  4. Pawel Szulc
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  5. Rodolfo Rivas-Ruiz
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  6. Jorge Salmerón
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Corresponding author

Correspondence to Edgar Denova-Gutiérrez.

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Conflicts of Interest

Patricia Clark, Edgar Denova-Gutiérrez, Regina Ambrosi, Pawel Szulc, Rodolfo Rivas, and Jorge Salmerón declare that there is no conflict of interest in submitting this manuscript for publication.

Human and Animal Rights and Informed Consent

This study was managed according to the Declaration of Helsinki guidelines. The ethics committees of all participating institutions [Comité de Ética e Investigación, Instituto Mexicano del Seguro Social (No. 12CEI0900614); Comité de Ética e Investigación, Instituto Nacional de Salud Pública (No.13CEI1700736); Comité de Ética, Centro de Investigación en Ciencias Médicas (No.1233008X0236)] reviewed and approved the study protocol and informed consent forms.

Additional information

An erratum to this article is available at http://dx.doi.org/10.1007/s00223-016-0207-6.

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Clark, P., Denova-Gutiérrez, E., Ambrosi, R. et al. Reference Values of Total Lean Mass, Appendicular Lean Mass, and Fat Mass Measured with Dual-Energy X-ray Absorptiometry in a Healthy Mexican Population. Calcif Tissue Int 99, 462–471 (2016). https://doi.org/10.1007/s00223-016-0181-z

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  • DOI: https://doi.org/10.1007/s00223-016-0181-z

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