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The Relationship of Bone Mineral Density to Oxidant/Antioxidant Status and Inflammatory and Bone Turnover Markers in a Multicenter Cross-Sectional Study of Young Men with Ankylosing Spondylitis

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Abstract

Low bone mineral density (BMD) is an important complication of ankylosing spondylitis (AS) that seriously affects men and their quality of life, even in young patients. However, the relationships among redox; levels of bone turnover markers (BTMs), inflammatory markers and disease activity; and low BMD in AS require clarification. We recruited 102 men aged 30–39 year with AS and 102 healthy, sex- and age-matched controls for this cross-sectional study. The subjects were analyzed for lumbar spine and femoral neck BMD by dual-energy X-ray absorptiometry. Significantly lower BMD and corresponding T-scores were observed in the AS patients compared with the controls (P < 0.05). The oxidant biomarker and antioxidant levels were significantly (P < 0.05) higher and lower, respectively, in the AS subjects compared with the controls, and the bone resorption and inflammatory marker levels were higher (P < 0.05). In subgroup analyses, the patients with osteoporosis or active disease had the highest levels of oxidant biomarkers (P < 0.05). Furthermore, the BMD T-scores in AS were found to be negatively correlated with oxidative status (P < 0.05). Multivariate binary logistic analysis showed that low BMD in the AS patients was associated with higher levels of advanced oxidation protein products, malondialdehyde and C-terminal telopeptide of type I collagen; lower levels of glutathione peroxidase; and higher scores of a bath ankylosing spondylitis metrology index. In conclusion, imbalanced redox was independently associated with low BMD in young men with AS and may play an important role in the pathogenesis of AS-related low BMD.

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Acknowledgments

This work was supported by the National Natural Science Foundation of China (No. 81271951, 81401850, 31200726), the Natural Science Foundation of Guangdong Province (S2012010009654, S2012010008927), the University Science and Technology Projects of Guangzhou City (1201430092), the Medicine and Health Care Technology Projects of Guangzhou City (20141A011099), the Medical Research Fund of Guangdong Province (B2014195), the Public Research and Capacity Building Special Funds of Guangdong Province (20140212624), and Engineering Technology Research Center of Guangdong province (GCZX-A1301).

Conflict of interest

Le Wang, Liangbin Gao, Dan Jin, Peng Wang, Bo Yang, Wen Deng, Zhongyu Xie, Yong Tang, Yanfeng Wu, and Huiyong Shen declare that they have no conflict of interest.

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    Authors and Affiliations

    1. Department of Orthopedics, Sun Yat-sen Memorial Hospital, Sun Yat-Sen University, 107# Yanjiangxi Road, Guangzhou, 510120, Guangdong, People’s Republic of China

      Le Wang, Liangbin Gao, Peng Wang, Zhongyu Xie, Yong Tang & Huiyong Shen

    2. Institute of Orthopaedics and Traumatology, the Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, People’s Republic of China

      Le Wang & Bo Yang

    3. Institute of Orthopaedics and Traumatology, Nanfang Hospital, Nanfang Medical University, Guangzhou, People’s Republic of China

      Dan Jin

    4. Biotherapy Centre, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107# Yanjiangxi Road, Guangzhou, 510120, Guangdong, People’s Republic of China

      Wen Deng & Yanfeng Wu

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    1. Le Wang
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    Correspondence to Yanfeng Wu or Huiyong Shen.

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    Yanfeng Wu and Huiyong Shen have contributed equally to this work.

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    Wang, L., Gao, L., Jin, D. et al. The Relationship of Bone Mineral Density to Oxidant/Antioxidant Status and Inflammatory and Bone Turnover Markers in a Multicenter Cross-Sectional Study of Young Men with Ankylosing Spondylitis. Calcif Tissue Int 97, 12–22 (2015). https://doi.org/10.1007/s00223-015-0001-x

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