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Leveling up: a long-range olivary projection to the medial geniculate without collaterals to the central nucleus of the inferior colliculus in rats

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Abstract

The medial nucleus of the trapezoid body (MNTB) is one of the monaural cell groups situated within the superior olivary complex (SOC), a constellation of brainstem nuclei with numerous roles in hearing. Principal MNTB neurons are glycinergic and express the calcium-binding protein, calbindin (CB). The MNTB receives its main glutamatergic, excitatory input from the contralateral cochlear nucleus via the calyx of Held and converts this into glycinergic inhibition directed toward nuclei in the SOC and the ventral and intermediate nuclei of the lateral lemniscus (VNLL and INLL). Through this inhibition, the MNTB plays essential roles in localization of sound sources and encoding spectral and temporal features of sound. In rats, very few MNTB neurons project to the inferior colliculus. However, our recent study of SOC projections to the auditory thalamus revealed a substantial number of retrogradely labeled MNTB neurons. This observation led us to examine whether the rat MNTB provides a long-range projection to the medial geniculate body (MGB). We examined this possible projection using retrograde and anterograde tract tracing and immunohistochemistry for CB and the glycine receptor. Our results demonstrate a significant projection to the MGB from the ipsilateral MNTB that does not involve a collateral projection to the inferior colliculus.

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Data availability statement

The data sets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.

Abbreviations

 + :

Positive

BIC:

Brachium of the inferior colliculus

CB:

Calbindin

CN:

Cochlear nucleus

CNIC:

Central nucleus of the inferior colliculus

cp:

Cerebral peduncle

D:

Dorsal

dMG:

Dorsal nucleus of the medial geniculate

DMW:

Dorsal medial wedge

DNLL:

Dorsal nucleus of the lateral lemniscus

ECIC:

External cortex of the inferior colliculus

FB:

Fast blue

fBDA:

Fluorescein tagged biotinylated dextran amine

FG:

Fluorogold

GBC:

Globular bushy cell

GlyR:

Glycine receptor

GLYT2:

Glycine transporter

IC:

Inferior colliculus

LL:

Lateral lemniscus

LNTB:

Lateral nucleus of the trapezoid body

LSO:

Lateral superior olive

M:

Medial

MGB:

Medial geniculate body

ml:

Medial lemniscus

mMG:

Medial nucleus of the medial geniculate

MNTB:

Medial nucleus of the trapezoid body

MSO:

Medial superior olive

NBIC:

Nucleus of the brachium of the inferior colliculus

NLL:

Nuclei of the lateral lemniscus

NT:

Neurotrace

P:

Postnatal

PAG:

Periaqueductal gray

PBS:

Phosphate buffered saline

PIL:

Posterior intralaminar nucleus

PN:

Pontine nuclei

PP:

Peripeduncular nucleus

SC:

Superior colliculus

scp:

Superior cerebellar peduncle

SG:

Suprageniculate nucleus

SN:

Substantia nigra

SOC:

Superior olivary complex

SPON:

Superior paraolivary nucleus

v:

Ventral

VCN:

Ventral cochlear nucleus

VG:

Ventral geniculate

vMG:

Ventral nucleus of the medial geniculate

VNLL:

Ventral nucleus of the lateral lemniscus

VNTB:

Ventral nucleus of the trapezoid body

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Acknowledgements

The authors would like to thank the Lake Erie Consortium for Osteopathic Medical Training for grant support for this project.

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Authors and Affiliations

  1. Department of Anatomy, Lake Erie College of Osteopathic Medicine, 1858 West Grandview Blvd, Erie, PA, 16509, USA

    Alyson Burchell, Yusra Mansour & Randy Kulesza

  2. Department of Otolaryngology, Henry Ford Macomb Hospital, Clinton Township, MI, USA

    Yusra Mansour

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  1. Alyson Burchell
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  2. Yusra Mansour
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AB: experimentation, data collection, data analysis, writing—review and editing. YM: conceptualization, experimentation, data collection, data analysis, writing—review and editing. RK: conceptualization, study design, resources, experimentation, project administration, writing—original draft, writing—review and editing.

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Correspondence to Randy Kulesza.

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Burchell, A., Mansour, Y. & Kulesza, R. Leveling up: a long-range olivary projection to the medial geniculate without collaterals to the central nucleus of the inferior colliculus in rats. Exp Brain Res 240, 3217–3235 (2022). https://doi.org/10.1007/s00221-022-06489-2

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