Abstract
The reticular thalamic nucleus (RTn) is a thin shell of GABAergic neurons that covers the dorsal thalamus that regulate the global activity of all thalamic nuclei. RTn controls the flow of information between thalamus and cerebral cortex since it receives glutamatergic information from collaterals of thalamo-cortical (TCs) and cortico-thalamic neurons. It also receives aminergic information from several brain stem nuclei, including serotonergic fibers originated in the dorsal raphe nucleus. RTn neurons express serotonergic receptors including the 5-HT1A subtype, however, the role of this receptor in the RTn electrical activity has been scarcely analyzed. In this work, we recorded in vivo the unitary spontaneous electrical activity of RTn neurons in anesthetized rats; our study aimed to obtain information about the effects of 5-HT1A receptors in RTn neurons. Local application of fluoxetine (a serotonin reuptake inhibitor) increases burst firing index accompanied by a decrease in the basal spiking rate. Local application of different doses of serotonin and 8-OH-DPAT (a specific 5-HT1A receptor agonist) causes a similar response to fluoxetine effects. Local 5-HT1A receptors blockade produces opposite effects and suppresses the effect by 8-OH-DPAT. Our findings indicate the presence of a serotonergic tonic discharge in the RTn that increases the burst firing index and simultaneously decreases the basal spiking frequency through 5-HT1A receptors activation.
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References
Aghajanian GK, Lakoski JM (1984) Hyperpolarization of serotonergic neurons by serotonin and LSD: studies in brain slices showing increased K+ conductance. Brain Res 305:181–185. https://doi.org/10.1016/0006-8993(84)91137-5
Amzica F, Nunez A, Steriade M (1992) Delta frequency (1–4 Hz) oscillations of perigeniculate thalamic neurons and their modulation by light. Neuroscience 51:285–294. https://doi.org/10.1016/0306-4522(92)90315-s
Anaya-Martinez V, Martinez-Marcos A, Martinez-Fong D, Aceves J, Erlij D (2006) Substantia nigra compacta neurons that innervate the reticular thalamic nucleus in the rat also project to striatum or globus pallidus: implications for abnormal motor behavior. Neuroscience 143:477–486. https://doi.org/10.1016/j.neuroscience.2006.08.033
Anticevic A, Yang G, Savic A et al (2014) Mediodorsal and visual thalamic connectivity differ in schizophrenia and bipolar disorder with and without psychosis history. Schizophr Bull 40:1227–1243. https://doi.org/10.1093/schbul/sbu100
Anticevic A, Haut K, Murray JD et al (2015) Association of thalamic dysconnectivity and conversion to psychosis in youth and young adults at elevated clinical risk. JAMA Psychiat 72:882–891. https://doi.org/10.1001/jamapsychiatry.2015.0566
Araneda R, Andrade R (1991) 5-Hydroxytryptamine2 and 5-hydroxytryptamine 1A receptors mediate opposing responses on membrane excitability in rat association cortex. Neuroscience 40:399–412. https://doi.org/10.1016/0306-4522(91)90128-b
Arborelius L, Linner L, Wallsten C, Ahlenius S, Svensson TH (2000) Partial 5-HT1A receptor agonist properties of (-)pindolol in combination with citalopram on serotonergic dorsal raphe cell firing in vivo. Psychopharmacology 151:77–84. https://doi.org/10.1007/s002130000470
Asanuma C (1992) Noradrenergic innervation of the thalamic reticular nucleus: a light and electron microscopic immunohistochemical study in rats. J Comp Neurol 319:299–311. https://doi.org/10.1002/cne.903190209
Ashby CR Jr, Edwards E, Wang RY (1994) Electrophysiological evidence for a functional interaction between 5-HT1A and 5-HT2A receptors in the rat medial prefrontal cortex: an iontophoretic study. Synapse 17:173–181. https://doi.org/10.1002/syn.890170306
Aznar S, Qian Z, Shah R, Rahbek B, Knudsen GM (2003) The 5-HT1A serotonin receptor is located on calbindin- and parvalbumin-containing neurons in the rat brain. Brain Res 959:58–67. https://doi.org/10.1016/s0006-8993(02)03727-7
Barrientos R, Alatorre A, Martinez-Escudero J, Garcia-Ramirez M, Oviedo-Chavez A, Delgado A, Querejeta E (2019) Effects of local activation and blockade of dopamine D4 receptors in the spiking activity of the reticular thalamic nucleus in normal and in ipsilateral dopamine-depleted rats. Brain Res 1712:34–46. https://doi.org/10.1016/j.brainres.2019.01.042
Ben-Ari Y, Dingledine R, Kanazawa I, Kelly JS (1976) Inhibitory effects of acetylcholine on neurones in the feline nucleus reticularis thalami. J Physiol 261:647–671. https://doi.org/10.1113/jphysiol.1976.sp011579
Bergstrom DA, Walters JR (1981) Neuronal responses of the globus pallidus to systemic administration of d-amphetamine: investigation of the involvement of dopamine, norepinephrine, and serotonin. J Neurosci 1:292–299
Boutros NN, Arfken C, Galderisi S, Warrick J, Pratt G, Iacono W (2008) The status of spectral EEG abnormality as a diagnostic test for schizophrenia. Schizophr Res 99:225–237. https://doi.org/10.1016/j.schres.2007.11.020
Branchereau P, Chapron J, Meyrand P (2002) Descending 5-hydroxytryptamine raphe inputs repress the expression of serotonergic neurons and slow the maturation of inhibitory systems in mouse embryonic spinal cord. J Neurosci 22:2598–2606
Carhart-Harris RL, Muthukumaraswamy S, Roseman L et al (2016) Neural correlates of the LSD experience revealed by multimodal neuroimaging. Proc Natl Acad Sci USA 113:4853–4858. https://doi.org/10.1073/pnas.1518377113
Clemente-Perez A, Makinson SR, Higashikubo B et al (2017) Distinct thalamic reticular cell types differentially modulate normal and pathological cortical rhythms. Cell Rep 19:2130–2142. https://doi.org/10.1016/j.celrep.2017.05.044
Corradetti R, Le Poul E, Laaris N, Hamon M, Lanfumey L (1996) Electrophysiological effects of N-(2-(4-(2-methoxyphenyl)-1-piperazinyl)ethyl)-N-(2-pyridinyl) cyclohexane carboxamide (WAY 100635) on dorsal raphe serotonergic neurons and CA1 hippocampal pyramidal cells in vitro. J Pharmacol Exp Ther 278:679–688
Cossery JM, Gozlan H, Spampinato U, Perdicakis C, Guillaumet G, Pichat L, Hamon M (1987) The selective labelling of central 5-HT1A receptor binding sites by [3H]5-methoxy-3-(di-n-propylamino)chroman. Eur J Pharmacol 140:143–155. https://doi.org/10.1016/0014-2999(87)90800-4
Courtney NA, Ford CP (2016) Mechanisms of 5-HT1A receptor-mediated transmission in dorsal raphe serotonin neurons. J Physiol 594:953–965. https://doi.org/10.1113/JP271716
Domich L, Oakson G, Steriade M (1986) Thalamic burst patterns in the naturally sleeping cat: a comparison between cortically projecting and reticularis neurones. J Physiol 379:429–449. https://doi.org/10.1113/jphysiol.1986.sp016262
Ferrarelli F, Tononi G (2011) The thalamic reticular nucleus and schizophrenia. Schizophr Bull 37:306–315. https://doi.org/10.1093/schbul/sbq142
Ferrarelli F, Peterson MJ, Sarasso S et al (2010) Thalamic dysfunction in schizophrenia suggested by whole-night deficits in slow and fast spindles. Am J Psychiatry 167:1339–1348. https://doi.org/10.1176/appi.ajp.2010.09121731
Fitzpatrick D, Penny GR, Schmechel DE (1984) Glutamic acid decarboxylase-immunoreactive neurons and terminals in the lateral geniculate nucleus of the cat. J Neurosci 4:1809–1829
Fornal CA, Martin FJ, Metzler CW, Jacobs BL (1999a) Pindolol suppresses serotonergic neuronal activity and does not block the inhibition of serotonergic neurons produced by 8-hydroxy-2-(di-n-propylamino)tetralin in awake cats. J Pharmacol Exp Ther 291:229–238
Fornal CA, Martin FJ, Metzler CW, Jacobs BL (1999b) Pindolol, a putative 5-hydroxytryptamine(1A) antagonist, does not reverse the inhibition of serotonergic neuronal activity induced by fluoxetine in awake cats: comparison to WAY-100635. J Pharmacol Exp Ther 291:220–228
Fuentealba P, Steriade M (2005) The reticular nucleus revisited: intrinsic and network properties of a thalamic pacemaker. Prog Neurobiol 75:125–141. https://doi.org/10.1016/j.pneurobio.2005.01.002
Funke K, Eysel UT (1993) Modulatory effects of acetylcholine, serotonin and noradrenaline on the activity of cat perigeniculate neurons. Exp Brain Res 95:409–420. https://doi.org/10.1007/BF00227133
Gantz SC, Bunzow JR, Williams JT (2013) Spontaneous inhibitory synaptic currents mediated by a G protein-coupled receptor. Neuron 78:807–812. https://doi.org/10.1016/j.neuron.2013.04.013
Garratt JC, Alreja M, Aghajanian GK (1993) LSD has high efficacy relative to serotonin in enhancing the cationic current Ih: intracellular studies in rat facial motoneurons. Synapse 13:123–134. https://doi.org/10.1002/syn.890130205
Ghosh M, Pearse DD (2014) The role of the serotonergic system in locomotor recovery after spinal cord injury. Front Neural Circuits 8:151. https://doi.org/10.3389/fncir.2014.00151
Goitia B, Rivero-Echeto MC, Weisstaub NV, Gingrich JA, Garcia-Rill E, Bisagno V, Urbano FJ (2016) Modulation of GABA release from the thalamic reticular nucleus by cocaine and caffeine: role of serotonin receptors. J Neurochem 136:526–535. https://doi.org/10.1111/jnc.13398
Haj-Dahmane S, Hamon M, Lanfumey L (1991) K+ channel and 5-hydroxytryptamine1A autoreceptor interactions in the rat dorsal raphe nucleus: an in vitro electrophysiological study. Neuroscience 41:495–505. https://doi.org/10.1016/0306-4522(91)90344-n
Halassa MM, Chen Z, Wimmer RD et al (2014) State-dependent architecture of thalamic reticular subnetworks. Cell 158:808–821. https://doi.org/10.1016/j.cell.2014.06.025
Han D, Shi S, Luo H (2019) The therapeutic effect of quetiapine on cognitive impairment associated with 5-HT1A presynaptic receptor involved schizophrenia. J Integr Neurosci 18:245–251. https://doi.org/10.31083/j.jin.2019.03.186
Hashimoto T, Nishino N, Nakai H, Tanaka C (1991) Increase in serotonin 5-HT1A receptors in prefrontal and temporal cortices of brains from patients with chronic schizophrenia. Life Sci 48:355–363. https://doi.org/10.1016/0024-3205(91)90556-q
Heckers S, Geula C, Mesulam MM (1992) Cholinergic innervation of the human thalamus: dual origin and differential nuclear distribution. J Comp Neurol 325:68–82. https://doi.org/10.1002/cne.903250107
Innis RB, Nestler EJ, Aghajanian GK (1988) Evidence for G protein mediation of serotonin- and GABAB-induced hyperpolarization of rat dorsal raphe neurons. Brain Res 459:27–36. https://doi.org/10.1016/0006-8993(88)90282-x
Kayama Y, Shimada S, Hishikawa Y, Ogawa T (1989) Effects of stimulating the dorsal raphe nucleus of the rat on neuronal activity in the dorsal lateral geniculate nucleus. Brain Res 489:1–11. https://doi.org/10.1016/0006-8993(89)90002-4
Korpi ER, Kleinman JE, Goodman SI, Phillips I, DeLisi LE, Linnoila M, Wyatt RJ (1986) Serotonin and 5-hydroxyindoleacetic acid in brains of suicide victims. comparison in chronic schizophrenic patients with suicide as cause of death. Arch Gen Psychiatry 43:594–600. https://doi.org/10.1001/archpsyc.1986.01800060088011
Lee KH, McCormick DA (1996) Abolition of spindle oscillations by serotonin and norepinephrine in the ferret lateral geniculate and perigeniculate nuclei in vitro. Neuron 17:309–321. https://doi.org/10.1016/s0896-6273(00)80162-2
Lewis LD, Voigts J, Flores FJ, Schmitt LI, Wilson MA, Halassa MM, Brown EN (2015) Thalamic reticular nucleus induces fast and local modulation of arousal state. Elife 4:e08760. https://doi.org/10.7554/eLife.08760
Lipska BK, Jaskiw GE, Arya A, Weinberger DR (1992) Serotonin depletion causes long-term reduction of exploration in the rat. Pharmacol Biochem Behav 43:1247–1252. https://doi.org/10.1016/0091-3057(92)90510-m
Marcinkiewcz CA, Mazzone CM, D’Agostino G et al (2016) Serotonin engages an anxiety and fear-promoting circuit in the extended amygdala. Nature 537:97–101. https://doi.org/10.1038/nature19318
Marcinkiewicz M, Verge D, Gozlan H, Pichat L, Hamon M (1984) Autoradiographic evidence for the heterogeneity of 5-HT1 sites in the rat brain. Brain Res 291:159–163. https://doi.org/10.1016/0006-8993(84)90664-4
Marks GA, Speciale SG, Cobbey K, Roffwarg HP (1987) Serotonergic inhibition of the dorsal lateral geniculate nucleus. Brain Res 418:76–84. https://doi.org/10.1016/0006-8993(87)90964-4
McCormick DA, Bal T (1997) Sleep and arousal: thalamocortical mechanisms. Annu Rev Neurosci 20:185–215. https://doi.org/10.1146/annurev.neuro.20.1.185
McCormick DA, Pape HC (1990) Noradrenergic and serotonergic modulation of a hyperpolarization-activated cation current in thalamic relay neurones. J Physiol 431:319–342. https://doi.org/10.1113/jphysiol.1990.sp018332
McCormick DA, Wang Z (1991) Serotonin and noradrenaline excite GABAergic neurones of the guinea-pig and cat nucleus reticularis thalami. J Physiol 442:235–255. https://doi.org/10.1113/jphysiol.1991.sp018791
McGinty DJ, Harper RM (1976) Dorsal raphe neurons: depression of firing during sleep in cats. Brain Res 101:569–575. https://doi.org/10.1016/0006-8993(76)90480-7
McKenna DJ, Repke DB, Lo L, Peroutka SJ (1990) Differential interactions of indolealkylamines with 5-hydroxytryptamine receptor subtypes. Neuropharmacology 29:193–198. https://doi.org/10.1016/0028-3908(90)90001-8
Millan MJ (2000) Improving the treatment of schizophrenia: focus on serotonin (5-HT)(1A) receptors. J Pharmacol Exp Ther 295:853–861
Monckton JE, McCormick DA (2002) Neuromodulatory role of serotonin in the ferret thalamus. J Neurophysiol 87:2124–2136. https://doi.org/10.1152/jn.00650.2001
Monti JM (2011) Serotonin control of sleep-wake behavior. Sleep Med Rev 15:269–281. https://doi.org/10.1016/j.smrv.2010.11.003
Moore RY, Halaris AE, Jones BE (1978) Serotonin neurons of the midbrain raphe: ascending projections. J Comp Neurol 180:417–438. https://doi.org/10.1002/cne.901800302
Morrison JH, Foote SL (1986) Noradrenergic and serotoninergic innervation of cortical, thalamic, and tectal visual structures in Old and New World monkeys. J Comp Neurol 243:117–138. https://doi.org/10.1002/cne.902430110
Nelson DL (1993) The serotonin2 (5-HT_2) subfamily of receptors : pharmacological challenges. Med Chem Res 3:306–316
Newman-Tancredi A (2010) The importance of 5-HT1A receptor agonism in antipsychotic drug action: rationale and perspectives. Curr Opin Investig Drugs 11:802–812
Nichols DE (2000) Role of serotoninergic neurons and 5-HT receptors in the action of hallucinogens. In: Baumgarten HG, Göthert M (eds) Serotoninergic neurons and 5-HT receptors in the CNS. Springer Berlin Heidelberg, Berlin, Heidelberg, pp 563–585
Norman AB, Battaglia G, Creese I (1985) [3H]WB4101 labels the 5-HT1A serotonin receptor subtype in rat brain. Guanine nucleotide and divalent cation sensitivity. Mol Pharmacol 28:487–494
Nunez A, Curro Dossi R, Contreras D, Steriade M (1992) Intracellular evidence for incompatibility between spindle and delta oscillations in thalamocortical neurons of cat. Neuroscience 48:75–85. https://doi.org/10.1016/0306-4522(92)90339-4
Pare D, Smith Y, Parent A, Steriade M (1988) Projections of brainstem core cholinergic and non-cholinergic neurons of cat to intralaminar and reticular thalamic nuclei. Neuroscience 25:69–86. https://doi.org/10.1016/0306-4522(88)90007-3
Parsey RV, Oquendo MA, Ogden RT et al (2006) Altered serotonin 1A binding in major depression: a [carbonyl-C-11]WAY100635 positron emission tomography study. Biol Psychiatry 59:106–113. https://doi.org/10.1016/j.biopsych.2005.06.016
Paxinos G, Watson C (2006) The rat brain in stereotaxic coordinates: hard cover edition. Elsevier, Amsterdam
Pazos A, Palacios JM (1985) Quantitative autoradiographic mapping of serotonin receptors in the rat brain. I. Serotonin-1 receptors. Brain Res 346:205–230. https://doi.org/10.1016/0006-8993(85)90856-x
Penington NJ, Kelly JS, Fox AP (1993) Unitary properties of potassium channels activated by 5-HT in acutely isolated rat dorsal raphe neurones. J Physiol 469:407–426. https://doi.org/10.1113/jphysiol.1993.sp019820
Peroutka SJ, Snyder SH (1979) Multiple serotonin receptors: differential binding of [3H]5-hydroxytryptamine, [3H]lysergic acid diethylamide and [3H]spiroperidol. Mol Pharmacol 16:687–699
Pinault D (2004) The thalamic reticular nucleus: structure, function and concept. Brain Res Brain Res Rev 46:1–31. https://doi.org/10.1016/j.brainresrev.2004.04.008
Pratt JA, Morris BJ (2015) The thalamic reticular nucleus: a functional hub for thalamocortical network dysfunction in schizophrenia and a target for drug discovery. J Psychopharmacol 29:127–137. https://doi.org/10.1177/0269881114565805
Querejeta E, Oviedo-Chavez A, Araujo-Alvarez JM, Quinones-Cardenas AR, Delgado A (2005) In vivo effects of local activation and blockade of 5-HT1B receptors on globus pallidus neuronal spiking. Brain Res 1043:186–194. https://doi.org/10.1016/j.brainres.2005.02.055
Reissig CJ, Eckler JR, Rabin RA, Winter JC (2005) The 5-HT1A receptor and the stimulus effects of LSD in the rat. Psychopharmacology 182:197–204. https://doi.org/10.1007/s00213-005-0068-6
Richter-Levin G, Segal M (1991) The effects of serotonin depletion and raphe grafts on hippocampal electrophysiology and behavior. J Neurosci 11:1585–1596
Rodriguez JJ, Noristani HN, Hoover WB, Linley SB, Vertes RP (2011) Serotonergic projections and serotonin receptor expression in the reticular nucleus of the thalamus in the rat. Synapse 65:919–928. https://doi.org/10.1002/syn.20920
Rogawski MA, Aghajanian GK (1980) Norepinephrine and serotonin: opposite effects on the activity of lateral geniculate neurons evoked by optic pathway stimulation. Exp Neurol 69:678–694. https://doi.org/10.1016/0014-4886(80)90060-6
Schulman JJ, Cancro R, Lowe S, Lu F, Walton KD, Llinas RR (2011) Imaging of thalamocortical dysrhythmia in neuropsychiatry. Front Hum Neurosci 5:69. https://doi.org/10.3389/fnhum.2011.00069
Segal M (1975) Physiological and pharmacological evidence for a serotonergic projection to the hippocampus. Brain Res 94:115–131. https://doi.org/10.1016/0006-8993(75)90881-1
Sotelo C, Cholley B, El Mestikawy S, Gozlan H, Hamon M (1990) Direct immunohistochemical evidence of the existence of 5-HT1A autoreceptors on serotoninergic neurons in the midbrain raphe nuclei. Eur J Neurosci 2:1144–1154. https://doi.org/10.1111/j.1460-9568.1990.tb00026.x
Soto E, Vega R (1987) A Turbo Pascal program for on line spike data acquisition and analysis using a standard serial port. J Neurosci Methods 19:61–68. https://doi.org/10.1016/0165-0270(87)90021-5
Soto-Sanchez C, Wang X, Vaingankar V, Sommer FT, Hirsch JA (2017) Spatial scale of receptive fields in the visual sector of the cat thalamic reticular nucleus. Nat Commun 8:800. https://doi.org/10.1038/s41467-017-00762-7
Sprouse JS, Aghajanian GK (1987) Electrophysiological responses of serotoninergic dorsal raphe neurons to 5-HT1A and 5-HT1B agonists. Synapse 1:3–9. https://doi.org/10.1002/syn.890010103
Steriade M (2005) Sleep, epilepsy and thalamic reticular inhibitory neurons. Trends Neurosci 28:317–324. https://doi.org/10.1016/j.tins.2005.03.007
Steriade M, Deschenes M (1984) The thalamus as a neuronal oscillator. Brain Res 320:1–63. https://doi.org/10.1016/0165-0173(84)90017-1
Steriade M, Llinas RR (1988) The functional states of the thalamus and the associated neuronal interplay. Physiol Rev 68:649–742. https://doi.org/10.1152/physrev.1988.68.3.649
Steriade M, Deschenes M, Domich L, Mulle C (1985) Abolition of spindle oscillations in thalamic neurons disconnected from nucleus reticularis thalami. J Neurophysiol 54:1473–1497. https://doi.org/10.1152/jn.1985.54.6.1473
Steriade M, Domich L, Oakson G, Deschenes M (1987) The deafferented reticular thalamic nucleus generates spindle rhythmicity. J Neurophysiol 57:260–273. https://doi.org/10.1152/jn.1987.57.1.260
Steriade M, McCormick DA, Sejnowski TJ (1993) Thalamocortical oscillations in the sleeping and aroused brain. Science 262:679–685. https://doi.org/10.1126/science.8235588
Sumiyoshi T, Stockmeier CA, Overholser JC, Dilley GE, Meltzer HY (1996) Serotonin1A receptors are increased in postmortem prefrontal cortex in schizophrenia. Brain Res 708:209–214. https://doi.org/10.1016/0006-8993(95)01361-x
Takekita Y, Fabbri C, Kato M et al (2015) HTR1A Gene Polymorphisms and 5-HT1A Receptor Partial Agonist Antipsychotics Efficacy in Schizophrenia. J Clin Psychopharmacol 35:220–227. https://doi.org/10.1097/JCP.0000000000000304
Ushimaru M, Ueta Y, Kawaguchi Y (2012) Differentiated participation of thalamocortical subnetworks in slow/spindle waves and desynchronization. J Neurosci 32:1730–1746. https://doi.org/10.1523/JNEUROSCI.4883-11.2012
Van den Hooff P, Galvan M (1991) Electrophysiology of the 5-HT1A ligand MDL 73005EF in the rat hippocampal slice. Eur J Pharmacol 196:291–298. https://doi.org/10.1016/0014-2999(91)90442-s
Van den Hooff P, Galvan M (1992) Actions of 5-hydroxytryptamine and 5-HT1A receptor ligands on rat dorso-lateral septal neurones in vitro. Br J Pharmacol 106:893–899. https://doi.org/10.1111/j.1476-5381.1992.tb14431.x
van Wijngaarden I, Tulp MT, Soudijn W (1990) The concept of selectivity in 5-HT receptor research. Eur J Pharmacol 188:301–312. https://doi.org/10.1016/0922-4106(90)90190-9
Vandermaelen CP, Aghajanian GK (1983) Electrophysiological and pharmacological characterization of serotonergic dorsal raphe neurons recorded extracellularly and intracellularly in rat brain slices. Brain Res 289:109–119. https://doi.org/10.1016/0006-8993(83)90011-2
Velayos JL, Jimenez-Castellanos J Jr, Reinoso-Suarez F (1989) Topographical organization of the projections from the reticular thalamic nucleus to the intralaminar and medial thalamic nuclei in the cat. J Comp Neurol 279:457–469. https://doi.org/10.1002/cne.902790310
Venables NC, Bernat EM, Sponheim SR (2009) Genetic and disorder-specific aspects of resting state EEG abnormalities in schizophrenia. Schizophr Bull 35:826–839. https://doi.org/10.1093/schbul/sbn021
Verge D, Daval G, Patey A, Gozlan H, el Mestikawy S, Hamon M (1985) Presynaptic 5-HT autoreceptors on serotonergic cell bodies and/or dendrites but not terminals are of the 5-HT1A subtype. Eur J Pharmacol 113:463–464. https://doi.org/10.1016/0014-2999(85)90099-8
Verge D, Daval G, Marcinkiewicz M, Patey A, el Mestikawy S, Gozlan H, Hamon M (1986) Quantitative autoradiography of multiple 5-HT1 receptor subtypes in the brain of control or 5,7-dihydroxytryptamine-treated rats. J Neurosci 6:3474–3482
Villalobos N, Oviedo-Chavez A, Alatorre A, Rios A, Barrientos R, Delgado A, Querejeta E (2016) Striatum and globus pallidus control the electrical activity of reticular thalamic nuclei. Brain Res 1644:258–266. https://doi.org/10.1016/j.brainres.2016.05.032
Wright DE, Seroogy KB, Lundgren KH, Davis BM, Jennes L (1995) Comparative localization of serotonin1A, 1C, and 2 receptor subtype mRNAs in rat brain. J Comp Neurol 351:357–373. https://doi.org/10.1002/cne.903510304
Yoshida M, Sasa M, Takaori S (1984) Serotonin-mediated inhibition from dorsal raphe nucleus of neurons in dorsal lateral geniculate and thalamic reticular nuclei. Brain Res 290:95–105. https://doi.org/10.1016/0006-8993(84)90739-x
Zhang JY, Ashby CR Jr, Wang RY (1994) Effect of pertussis toxin on the response of rat medial prefrontal cortex cells to the iontophoresis of serotonin receptor agonists. J Neural Transm Gen Sect 95:165–172. https://doi.org/10.1007/BF01271563
Zhang Y, Yoshida T, Katz DB, Lisman JE (2012) NMDAR antagonist action in thalamus imposes delta oscillations on the hippocampus. J Neurophysiol 107:3181–3189. https://doi.org/10.1152/jn.00072.2012
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Barrientos, R., Alatorre, A., Oviedo-Chávez, A. et al. Tonic serotonergic input increases the burst firing mode and diminishes the firing rate of reticular thalamic nucleus neurons through 5-HT1A receptors activation in anesthetized rats. Exp Brain Res 240, 1341–1356 (2022). https://doi.org/10.1007/s00221-022-06328-4
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DOI: https://doi.org/10.1007/s00221-022-06328-4