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Greater intracortical inhibition associates with lower quadriceps voluntary activation in individuals with ACL reconstruction

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Abstract

Decreased voluntary activation contributes to quadriceps weakness following anterior cruciate ligament reconstruction (ACLR). Alterations in neural excitability are likely responsible for reductions in quadriceps voluntary activation, and may be due to specific alterations in intracortical inhibition and facilitation. Therefore, we sought to determine if intracortical inhibition (SICI) and intracortical facilitation (ICF) associate with quadriceps voluntary activation in individuals with ACLR. Twenty-seven participants with a primary, unilateral ACLR were enrolled in this study. Bilateral central activation ratio (CAR) and paired-pulse transcranial magnetic stimulation were used to assess quadriceps voluntary activation, as well as SICI and ICF in the vastus medalis, respectively. Pearson Product Moment correlations were used to determine the association between CAR and (1) SICI, and (2) ICF in each limb. Lesser CAR associated with lesser SICI amplitude (r = 0.502, P = 0.008) in the ACLR limb. No associations in the contralateral limb were significant. Our results suggest greater intracortical inhibition associates with lesser voluntary activation in individuals with ACL. Implementing interventions that target intracortical inhibition may aid in restoring quadriceps voluntary activation following ACLR.

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Authors and Affiliations

  1. Human Movement Science Curriculum, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA

    Brittney A. Luc-Harkey & Matthew S. Harkey

  2. Department of Exercise and Sports Science, University of North Carolina at Chapel Hill, 209 Fetzer Hall, CB#8700, Chapel Hill, NC, 27599-8700, USA

    Brittney A. Luc-Harkey, Matthew S. Harkey, Rebecca H. Kim, Troy K. Royal, J. Troy Blackburn & Brian Pietrosimone

  3. Department of Kinesiology, California State University, Fullerton, USA

    Derek N. Pamukoff

  4. Department of Orthopaedics, School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA

    Jeffery T. Spang

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  1. Brittney A. Luc-Harkey
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  2. Matthew S. Harkey
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Correspondence to Brittney A. Luc-Harkey.

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Luc-Harkey, B.A., Harkey, M.S., Pamukoff, D.N. et al. Greater intracortical inhibition associates with lower quadriceps voluntary activation in individuals with ACL reconstruction. Exp Brain Res 235, 1129–1137 (2017). https://doi.org/10.1007/s00221-017-4877-8

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  • DOI: https://doi.org/10.1007/s00221-017-4877-8

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