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Preparation of PEG-modified proanthocyanidin liposome and its application in cosmetics

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Abstract

Proanthocyanidin liposome modified by polyethylene glycol (PEG) was prepared by reverse-phase evaporation method. To obtain the higher encapsulation efficiency of proanthocyanidin liposomes, several factors, including the mass ratio of lecithin to cholesterol and the addition of surfactants and PEG, were investigated. The liposomes then can be evaluated by encapsulation efficiency, the distribution of particle size and storage stability. The results showed that the encapsulation efficiency of the liposomes was around 77.28 %, and the average particle size of the liposomes was 144.9 ± 0.1 nm. In addition, proanthocyanidin could be controlled to release on simulated skin in vitro. These data confirmed that the liposomes could be employed to extend proanthocyanidin’s shelf life and to provide more convenience and better performance for its usage in cosmetics.

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Acknowledgments

This research was supported by the Key Laboratory of Science and Technology of Eco-Textile, Ministry of Education, Donghua University and College of Chemistry, Chemical Engineering and Biotechnology. Furthermore, we would especially like to thank Shanghai Inoherb Cosmetics Co, Ltd, for the financial support.

Conflict of interest

Fang Guo, Yu Gu, Xin Zhao, Guosheng Hu declare that they have no conflict of interest. Miao Lin has received research grants from Shanghai Inoherb Cosmetics Co, LTD.

Compliance with Ethics Requirements

This article does not contain any studies with human or animal subjects.

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Authors and Affiliations

  1. College of Chemistry, Chemical Engineering and Biotechnology, Key Laboratory of Science and Technology of Eco-Textile, Ministry of Education, Donghua University, Shanghai, 201620, People’s Republic of China

    Fang Guo, Miao Lin & Yu Gu

  2. Shanghai Inoherb Cosmetics Co, Ltd, Shanghai, 200444, People’s Republic of China

    Xin Zhao & Guosheng Hu

Authors
  1. Fang Guo
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  2. Miao Lin
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  3. Yu Gu
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  4. Xin Zhao
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  5. Guosheng Hu
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Correspondence to Miao Lin.

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Guo, F., Lin, M., Gu, Y. et al. Preparation of PEG-modified proanthocyanidin liposome and its application in cosmetics. Eur Food Res Technol 240, 1013–1021 (2015). https://doi.org/10.1007/s00217-014-2405-7

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  • DOI: https://doi.org/10.1007/s00217-014-2405-7

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