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MIL-53(Fe) MOF-mediated catalytic chemiluminescence for sensitive detection of glucose

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Abstract

Various analytical applications of metal–organic frameworks (MOFs) have been rapidly developed in the past few years. However, the employment of MOFs as catalysts in chemiluminescence (CL) analysis is rare. Here, for the first time, we found that MIL-53(Fe) MOFs could significantly enhance the CL of luminol in the presence of H2O2 in an alkaline medium. The CL intensity in the luminol–H2O2–MIL-53(Fe) system was about 20 times higher than that in the luminol–H2O2 system. Moreover, the XRD pattern of MIL-53(Fe) after CL reaction was almost the same as that of the original MIL-53(Fe), confirming the catalytic role of MIL-53(Fe) in the luminol–H2O2–MIL-53(Fe) system. The possible mechanism behind the enhancing phenomenon was discussed based on the results from the CL spectra, FL probe experiments, and active oxygen species measurements. By coupling with the glucose oxidase-based catalytic oxidation reaction, a sensitive and selective CL method was developed for the detection of glucose. There is a linear relationship between the logarithm of CL intensity and the logarithm of glucose concentration in the range from 0.1 to 10 μM, and a detection limit of 0.05 μM (S/N = 3) is obtained. The proposed method has been applied to the determination of glucose in human serum samples with satisfactory results.

MIL-53(Fe) MOFs are found to greatly enhance the chemiluminescence emission of the luminol–H2O2 system, and this finding resulted in a new chemiluminescence method for biosensing of glucose when coupled with the glucose oxidase.

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Acknowledgments

Financial support from the National Natural Science Foundation of China (21277111 and 21465024) and the Fundamental Research Funds for the Central Universities (XDJK 2016D019) are gratefully acknowledged.

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Authors and Affiliations

  1. The Key Laboratory of Luminescence and Real-Time Analytical Chemistry, Ministry of Education, College of Chemistry and Chemical Engineering, Southwest University, Beibei, Chongqing, 400715, China

    Xueling Yi, Wenfei Dong, Xiaodan Zhang & Yuming Huang

  2. College of Resources and Environment, Yuxi Normal University, Yuxi, Yunnan, 653100, China

    Jianxin Xie

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  1. Xueling Yi
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  2. Wenfei Dong
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  3. Xiaodan Zhang
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  4. Jianxin Xie
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Correspondence to Jianxin Xie or Yuming Huang.

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Published in the topical collection Highlights of Analytical Chemical Luminescence with guest editors Aldo Roda, Hua Cui, and Chao Lu.

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Yi, X., Dong, W., Zhang, X. et al. MIL-53(Fe) MOF-mediated catalytic chemiluminescence for sensitive detection of glucose. Anal Bioanal Chem 408, 8805–8812 (2016). https://doi.org/10.1007/s00216-016-9681-y

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  • DOI: https://doi.org/10.1007/s00216-016-9681-y

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