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Hollow fiber membrane-coated functionalized polymeric ionic liquid capsules for direct analysis of estrogens in milk samples

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Abstract

Protein removal process is always time-consuming for the analysis of milk samples. In this work, hollow fiber membrane-coated functionalized polymeric ionic liquid (HF-PIL) capsules were synthesized and used as solid-phase microextraction (SPME) sorbent for direct analysis of estrogens in milk samples. The functionalized PIL monolith sorbent was obtained by copolymerization between 1-(3-aminopropyl)-3-(4-vinylbenzyl)imidazolium 4-styrenesulfonate IL monomer and 1,6-di(3-vinylimidazolium) hexane bishexafluorophosphate IL-crosslinking agent. A group of four capsules were installed as SPME device, to determine four kinds of estrogens (estrone, diethylstilbestrol, hexestrol, and 17α-ethynylestradiol) in milk samples, coupled to high performance liquid chromatography. Extraction and desorption conditions were optimized to get satisfactory extraction efficiency. Good linearity was obtained in the range of 5–200 μg L−1. The limits of detection were 1 μg L−1 for diethylstilbestrol and 2 μg L−1 for 17α-ethynylestradiol, estrone, and hexestrol. The present method was applied to analyze the model analytes in different milk samples. Relative recoveries were in the range of 85.5–112 %. The HF-PIL SPME capsules showed satisfactory extraction efficiency and high resistance to sample matrix interference.

Direct analysis of estrogens in milk samples by hollow fiber membrane-coated functionalized polymeric ionic liquids SPME capsules.

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Acknowledgments

This work was supported by the National Natural Science Foundation of China (NSFC, Nos. 21405061 and 21205048), the Shandong Provincial Natural Science Foundation of China (No. ZR2014BQ019), and the Doctoral Foundation of University of Jinan (No. XBS1410).

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Authors and Affiliations

  1. Key Laboratory of Chemical Sensing & Analysis in Universities of Shandong (University of Jinan), School of Chemistry and Chemical Engineering, University of Jinan, Jinan, 250022, China

    Juanjuan Feng, Min Sun, Yanan Bu & Chuannan Luo

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  1. Juanjuan Feng
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  2. Min Sun
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  3. Yanan Bu
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  4. Chuannan Luo
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Correspondence to Min Sun.

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Feng, J., Sun, M., Bu, Y. et al. Hollow fiber membrane-coated functionalized polymeric ionic liquid capsules for direct analysis of estrogens in milk samples. Anal Bioanal Chem 408, 1679–1685 (2016). https://doi.org/10.1007/s00216-015-9279-9

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  • DOI: https://doi.org/10.1007/s00216-015-9279-9

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