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Certification of a new certified reference material of honokiol

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Abstract

Honokiol is the most important active pharmaceutical ingredient in Magnolia officinalis, which is a famous traditional Chinese medicine and commonly used in clinical practice. In order to control the quality of honokiol and related pharmaceuticals, a new certified reference material (CRM) of honokiol was developed. The studies of sample preparation, homogeneity, stability, value assignment, and uncertainty evaluation were accomplished in this paper. Three different methods, including differential scanning calorimetry (DSC), mass balance method (MB), and coulometric titration (CT), were employed to determine the purity of honokiol. Specifically, the DSC and CT methods for purity determination of honokiol were established for the first time. The purity of honokiol CRM, after validation and evaluation, was found to be 99.3 %, with an expanded uncertainty of 0.5 % (k = 2).

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Acknowledgments

We acknowledge the Ministry of Science and Technology of the PRC for the National Science and Technology Major Projects (Grant No. 2012ZX0930101002-001-013 and No. 2013ZX09102110) and the Fundamental Research project of IMM (Grant No. 2014ZD04).

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Authors and Affiliations

  1. Beijing Key Laboratory of Polymorphic Drugs, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China

    Shiying Yang, Dezhi Yang, Kun Hu, Haohui Zhou, Yonghui Guo & Yang Lu

  2. Beijing Key Laboratory of Drug Targets and Screening Research, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100050, China

    Guanhua Du

  3. Shandong Key laboratory of Polymorphic Drugs, Tengzhou, Shandong, 277500, China

    Yang Lu

Authors
  1. Shiying Yang
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  2. Dezhi Yang
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  3. Kun Hu
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  4. Haohui Zhou
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  5. Yonghui Guo
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  6. Guanhua Du
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  7. Yang Lu
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Corresponding author

Correspondence to Yang Lu.

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Yang, S., Yang, D., Hu, K. et al. Certification of a new certified reference material of honokiol. Anal Bioanal Chem 407, 5849–5855 (2015). https://doi.org/10.1007/s00216-015-8769-0

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  • DOI: https://doi.org/10.1007/s00216-015-8769-0

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